{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:27:00Z","timestamp":1790706420167,"version":"4.1.0"},"reference-count":102,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:00:00Z","timestamp":1633651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Changes in brain connectivity during language therapy were examined among participants with aphasia (PWA), aiming to shed light on neural reorganization in the language network. Four PWA with anomia following left hemisphere stroke and eight healthy controls (HC) participated in the study. Two fMRI scans were administered to all participants with a 3.5-month interval. The fMRI scans included phonological and semantic tasks, each consisting of linguistic and perceptual matching conditions. Between the two fMRI scans, PWA underwent Phonological Components Analysis treatment. Changes in effective connectivity during the treatment were examined within right hemisphere (RH) architecture. The results illustrate that following the treatment, the averaged connectivity of PWA across all perceptual and linguistic conditions in both tasks increased resemblance to HC, reflecting the normalization of neural processes associated with silent object name retrieval. In contrast, connections that were specifically enhanced by the phonological condition in PWA decreased in their resemblance to HC, reflecting emerging compensatory reorganization in RH connectivity to support phonological processing. These findings suggest that both normalization and compensation play a role in neural language reorganization at the chronic stage, occurring simultaneously in the same brain.<\/jats:p>","DOI":"10.3390\/brainsci11101330","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T23:37:08Z","timestamp":1633822628000},"page":"1330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Simultaneous Normalization and Compensatory Changes in Right Hemisphere Connectivity during Aphasia Therapy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6422-2866","authenticated-orcid":false,"given":"Tammar","family":"Truzman","sequence":"first","affiliation":[{"name":"Communication Sciences and Disorders Department and IIPDM, University of Haifa, Haifa 3498838, Israel"},{"name":"The Integrated Brain and Behavior Research Center, University of Haifa, Haifa 3498838, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-0513","authenticated-orcid":false,"given":"Elizabeth","family":"Rochon","sequence":"additional","affiliation":[{"name":"Department of Speech Language Pathology and Rehabilitation Sciences Institute, University of Toronto, Toronto, ON M5G 1V7, Canada"},{"name":"KITE Research Institute, Toronto Rehab, University Health Network (UHN), Toronto, ON M5G 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-1901","authenticated-orcid":false,"given":"Jed","family":"Meltzer","sequence":"additional","affiliation":[{"name":"Department of Speech Language Pathology and Rehabilitation Sciences Institute, University of Toronto, Toronto, ON M5G 1V7, Canada"},{"name":"Psychology Department, University of Toronto, Toronto, ON M5S 1A1, Canada"},{"name":"Rotman Research Institute, Baycrest Health Sciences, Toronto, ON M6A 2E1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Speech Language Pathology and Rehabilitation Sciences Institute, University of Toronto, Toronto, ON M5G 1V7, Canada"},{"name":"School of Rehabilitation Sciences, University of Ottawa, Ottawa, ON K1H 8L1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-587X","authenticated-orcid":false,"given":"Tali","family":"Bitan","sequence":"additional","affiliation":[{"name":"The Integrated Brain and Behavior Research Center, University of Haifa, Haifa 3498838, Israel"},{"name":"Department of Speech Language Pathology and Rehabilitation Sciences Institute, University of Toronto, Toronto, ON M5G 1V7, Canada"},{"name":"Psychology Department and IIPDM, University of Haifa, Haifa 3498838, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/0093-934X(79)90038-5","article-title":"Computer tomographic localization, lesion size, and prognosis in aphasia and nonverbal impairment","volume":"8","author":"Kertesz","year":"1979","journal-title":"Brain Lang."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Desai, R.H., and Riccardi, N. 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