{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:33:34Z","timestamp":1772969614943,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>(1) Objective: To evaluate the effectiveness of non-immersive virtual reality in reducing falls and improving balance in patients diagnosed with Parkinson\u2019s disease. (2) Methods: The following databases were searched: PUBMED, PEDro, Scielo, CINAHL, Web of Science, Dialnet, Scopus and MEDLINE. These databases were searched for randomized controlled trials published using relevant keywords in various combinations. The methodological quality of the articles was evaluated using the PEDro scale. (3) Results: A total of 10 studies with a total of 537 subjects, 58.7% of which (n = 315) were men, have been included in the review. The age of the participants in these studies ranged between 55 and 80 years. Each session lasted between 30 and 75 min, and the interventions lasted between 5 and 12 weeks. These studies showed that non-immersive virtual reality is effective in reducing the number of falls and improving both static and dynamic balance in patients diagnosed with Parkinson\u2019s disease. Results after non-immersive virtual reality intervention showed an improvement in balance and a decrease in the number and the risk of falls. However, no significant differences were found between the intervention groups and the control groups for all the included studies regarding balance. (4) Conclusions: There is evidence that non-immersive virtual reality can improve balance and reduce the risk and number of falls, being therefore beneficial for people diagnosed with Parkinson\u2019s disease.<\/jats:p>","DOI":"10.3390\/brainsci11111435","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:50:28Z","timestamp":1635465028000},"page":"1435","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Non-Immersive Virtual Reality to Improve Balance and Reduce Risk of Falls in People Diagnosed with Parkinson\u2019s Disease: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3160-7692","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Garc\u00eda-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Nursing, Physical Therapy and Medicine, University of Almeria, Road Sacramento s\/n, 04120 Almeria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-5500","authenticated-orcid":false,"given":"Esteban","family":"Obrero-Gait\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Jaen, Paraje Las Lagunillas s\/n, 23071 Jaen, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-3241","authenticated-orcid":false,"given":"Adelaida Mar\u00eda","family":"Castro-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physical Therapy and Medicine, University of Almeria, Road Sacramento s\/n, 04120 Almeria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-2063","authenticated-orcid":false,"given":"Inmaculada Carmen","family":"Lara-Palomo","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physical Therapy and Medicine, University of Almeria, Road Sacramento s\/n, 04120 Almeria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5301-9475","authenticated-orcid":false,"given":"Francisco Antonio","family":"Nieto-Escamez","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Almeria, Ctra. Sacramento s\/n, 04120 Almeria, Spain"},{"name":"Center for Neuropsychological Assessment and Rehabilitation (CERNEP), Ctra. Sacramento s\/n, 04120 Almeria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-1399","authenticated-orcid":false,"given":"Irene","family":"Cort\u00e9s-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Jaen, Paraje Las Lagunillas s\/n, 23071 Jaen, Spain"},{"name":"Granada Northeast Health District, Andalusian Health Service, Street San Miguel 2, 18500 Guadix, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson\u2019s disease: A systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/mds.25844","article-title":"Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson\u2019s disease","volume":"29","author":"Berg","year":"2014","journal-title":"Mov. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41531-018-0058-0","article-title":"Prevalence of Parkinson\u2019s disease across North America","volume":"4","author":"Marras","year":"2018","journal-title":"NPJ Park. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nrl.2016.05.017","article-title":"Influencia de la estimulaci\u00f3n cerebral profunda en la carga de cuidadores de pacientes con enfermedad de Parkinson","volume":"33","year":"2018","journal-title":"Neurolog\u00eda"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2125.2012.04192.x","article-title":"Progression of motor and nonmotor features of Parkinson\u2019s disease and their response to treatment","volume":"74","author":"Vu","year":"2012","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1177\/0269215519877498","article-title":"Measures of balance and falls risk prediction in people with Parkinson\u2019s disease: A systematic review of psychometric properties","volume":"33","author":"Winser","year":"2019","journal-title":"Clin. Rehabil."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s004150170047","article-title":"Prospective assessment of falls in Parkinson\u2019s disease","volume":"248","author":"Bloem","year":"2001","journal-title":"J. Neurol."},{"key":"ref_9","first-page":"2309","article-title":"Falling in Parkinson disease: More often due to postural instability than to environmental factors","volume":"144","author":"Willemsen","year":"2000","journal-title":"Ned. Tijdschr. Geneeskd."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e5004","DOI":"10.1136\/bmj.e5004","article-title":"Physiotherapy intervention in Parkinson\u2019s disease: Systematic review and meta-analysis","volume":"345","author":"Tomlinson","year":"2012","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm.2165","article-title":"Missing pieces in the Parkinson\u2019s disease puzzle","volume":"16","author":"Obeso","year":"2010","journal-title":"Nat. Med."},{"key":"ref_12","first-page":"189","article-title":"Levodopa-induced-dyskinesias clinical features, incidence, risk factors, management and impact on quality of life","volume":"2","author":"Manson","year":"2012","journal-title":"J. Park. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/mds.1090","article-title":"Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature","volume":"16","author":"Ahlskog","year":"2001","journal-title":"Mov. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/jnc.12751","article-title":"Dyskinesia in Parkinson\u2019s disease: Mechanisms and current non-pharmacological interventions","volume":"130","author":"Heumann","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.irn.2019.06.003","article-title":"Exercise and Parkinson\u2019s disease","volume":"147","author":"Xu","year":"2019","journal-title":"Int. Rev. Neurobiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"046006","DOI":"10.1088\/1741-2552\/aabc9b","article-title":"Adaptive deep brain stimulation for Parkinson\u2019s disease using motor cortex sensing","volume":"15","author":"Swann","year":"2018","journal-title":"J. Neural Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/mds.22364","article-title":"Effect of transcranial magnetic stimulation on Parkinson motor function-Systematic review of controlled clinical trials","volume":"24","author":"Elahi","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20140370","DOI":"10.1098\/rstb.2014.0370","article-title":"Treatment of Parkinson\u2019s disease using cell transplantation","volume":"370","author":"Lindvall","year":"2015","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fnhum.2020.00093","article-title":"Usability issues of clinical and research applications of virtual reality in older people: A systematic review","volume":"14","author":"Tuena","year":"2020","journal-title":"Front. Hum. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.pmr.2009.12.007","article-title":"The potential of virtual reality and gaming to assist successful aging with disability","volume":"21","author":"Lange","year":"2010","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/nrn3122","article-title":"Virtual reality in neuroscience research and therapy","volume":"12","author":"Bohil","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jmatprotec.2004.04.401","article-title":"Virtual reality applications in manufacturing process simulation","volume":"156","author":"Mujber","year":"2004","journal-title":"J. Mater. Process. Technol."},{"key":"ref_23","first-page":"453","article-title":"Virtual reality in rehabilitation and therapy","volume":"52","author":"Kolak","year":"2013","journal-title":"Acta Clin. Croat."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1743-0003-4-18","article-title":"Introduction to the special issue from the proceedings of the 2006 International Workshop on Virtual Reality in Rehabilitation","volume":"4","author":"Keshner","year":"2007","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.neuroimage.2013.05.031","article-title":"A semi-immersive virtual reality incremental swing balance task activates prefrontal cortex: A functional near-infrared spectroscopy study","volume":"85","author":"Moro","year":"2014","journal-title":"NeuroImage"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e22537","DOI":"10.2196\/22537","article-title":"Virtual reality systems for upper limb motor function recovery in patients with spinal cord injury: Systematic review and meta-analysis","volume":"8","author":"Rubio","year":"2020","journal-title":"JMIR Mhealth Uhealth"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1743-0003-7-48","article-title":"Neurorehabilitation using the virtual reality based Rehabilitation Gaming System: Methodology, design, psychometrics, usability and validation","volume":"7","author":"Oller","year":"2010","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_28","first-page":"3","article-title":"Control based on brain-bomputer interface technology for video-gaming with virtual reality techniques","volume":"10","author":"Paszkiel","year":"2016","journal-title":"J. Autom. Mob. Robot. Intell. Syst."},{"key":"ref_29","first-page":"223","article-title":"Efectos de la realidad virtual sobre el equilibrio y la marcha en el ictus: Revisi\u00f3n sistem\u00e1tica y metaan\u00e1lisis","volume":"69","author":"Couso","year":"2019","journal-title":"Rev. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., and Group, T.P. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Higgins, J., and Thomas, J. (2019). Cochrane Handbook for Systematic Reviews of Interventions, Wiley-Blackwell. [2nd ed.].","DOI":"10.1002\/9781119536604"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1590\/S0104-11692007000300023","article-title":"The PICO strategy for the research question construction and evidence search","volume":"15","author":"Santos","year":"2007","journal-title":"Rev. Lat. Am. Enferm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1532-5415.2011.03336.x","article-title":"Is timed up and go better than gait speed in predicting health, function, and falls in older adults?","volume":"59","author":"Ba","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Barry, E., Galvin, R., Keogh, C., Horgan, F., and Fahey, T. (2014). Is the Timed Up and Go test a useful predictor of risk of falls in community dwelling older adults: A systematic review and meta- analysis. BMC Geriatr., 14.","DOI":"10.1186\/1471-2318-14-14"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1054\/math.2000.0372","article-title":"PEDro. A database of randomized trials and systematic reviews in physiotherapy","volume":"5","author":"Sherringtonab","year":"2000","journal-title":"Man. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jclinepi.2009.10.005","article-title":"There was evidence of convergent and construct validity of Physiotherapy Evidence Database quality scale for physiotherapy trials","volume":"63","author":"Macedo","year":"2010","journal-title":"J. Clin. Epidemiol."},{"key":"ref_37","first-page":"1198","article-title":"Falls risk in relation to activity exposure in high-risk older adults","volume":"75","author":"Galna","year":"2020","journal-title":"J. Gerontol. Ser. A Boil. Sci. Med. Sci."},{"key":"ref_38","first-page":"722","article-title":"A multimodal training modulates short-afferent inhibition and improves complex walking in a cohort of faller older adults with an increased prevalence of Parkinson\u2019s disease","volume":"75","author":"Pelosin","year":"2019","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3233\/NRE-192771","article-title":"Efficacy of the Nintendo Wii combination with Conventional Exercises in the rehabilitation of individuals with Parkinson\u2019s disease: A randomized clinical trial","volume":"45","author":"Santos","year":"2019","journal-title":"Neurorehabilitation"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.12659\/MSM.916455","article-title":"Virtual reality rehabilitation versus conventional physical therapy for improving balance and gait in Parkinson\u2019s Disease patients: A randomized controlled trial","volume":"25","author":"Feng","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/7962826","article-title":"Virtual reality telerehabilitation for postural instability in Parkinson\u2019s Disease: A multicenter, single-blind, randomized, controlled trial","volume":"2017","author":"Gandolfi","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0140-6736(16)31325-3","article-title":"Addition of a non-immersive virtual reality component to treadmill training to reduce fall risk in older adults (V-TIME): A randomised controlled trial","volume":"388","author":"Mirelman","year":"2016","journal-title":"Lancet"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jbmt.2016.06.001","article-title":"Nintendo Wii Fit for balance rehabilitation in patients with Parkinson\u2019s disease: A comparative study","volume":"21","author":"Negrini","year":"2017","journal-title":"J. Bodyw. Mov. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jfma.2015.07.012","article-title":"Home-based virtual reality balance training and conventional balance training in Parkinson\u2019s disease: A randomized controlled trial","volume":"115","author":"Yang","year":"2016","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1589\/jpts.27.145","article-title":"Effect of virtual reality dance exercise on the balance, activities of daily living, and depressive disorder status of Parkinson\u2019s disease patients","volume":"27","author":"Lee","year":"2015","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1177\/1545968314562111","article-title":"Virtual reality\u2013based training to improve obstacle-crossing performance and dynamic balance in patients with Parkinson\u2019s Disease","volume":"29","author":"Liao","year":"2014","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1007\/s00415-013-7037-5","article-title":"Ambulatory activity in incident Parkinson\u2019s: More than meets the eye?","volume":"260","author":"Lord","year":"2013","journal-title":"J. Neurol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1080\/09638280600960909","article-title":"Virtual reality in stroke rehabilitation: Still more virtual than real","volume":"29","author":"Crosbie","year":"2007","journal-title":"Disabil. Rehabil."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.apmr.2019.03.013","article-title":"Efficacy of virtual reality combined with real instrument training for patients with stroke: A randomized controlled trial","volume":"100","author":"Oh","year":"2019","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1590\/0004-282x20190129","article-title":"Effect of Leap Motion-based 3D Immersive Virtual Reality Usage on Upper Extremity Function in Ischemic Stroke Patients","volume":"77","author":"Kurul","year":"2019","journal-title":"Arq. Neuro Psiquiatr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/09593985.2015.1138009","article-title":"Comparison of the effects of virtual reality-based balance exercises and conventional exercises on balance and fall risk in older adults living in nursing homes in Turkey","volume":"32","author":"Tomruk","year":"2016","journal-title":"Physiother. Theory Pr."},{"key":"ref_52","first-page":"16763","article-title":"Virtual reality intervention to help improve motor function in patients undergoing rehabilitation for Cerebral Palsy, Parkinson\u2019s Disease, or Stroke: A systematic review of randomized controlled trials","volume":"13","author":"Amirthalingam","year":"2021","journal-title":"Cureus"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/11\/1435\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:22:10Z","timestamp":1760167330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/11\/1435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,28]]},"references-count":52,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["brainsci11111435"],"URL":"https:\/\/doi.org\/10.3390\/brainsci11111435","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,28]]}}}