{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:53:25Z","timestamp":1780480405159,"version":"3.54.1"},"reference-count":52,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This study was funded by the National Research Foundation of Korea","award":["2019R1I1A3A01060059"],"award-info":[{"award-number":["2019R1I1A3A01060059"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Transcranial alternating current stimulation (tACS) is a neuromodulation procedure that is currently studied for the purpose of improving cognitive function in various diseases. A few studies have shown positive effects of tACS in Alzheimer\u2019s disease (AD). However, the mechanism underlying tACS has not been established. The purpose of this study was to investigate the mechanism of tACS in five familial AD mutation (5xFAD) mouse models. We prepared twenty 4-month-old mice and divided them into four groups: wild-type mice without stimulation (WT-NT group), wild-type mice with tACS (WT-T group), 5xFAD mice without stimulation (AD-NT group), and 5xFAD mice with tACS (AD-T group). The protocol implemented was as follows: gamma frequency 200 \u03bcA over the bilateral frontal lobe for 20 min over 2 weeks. The following tests were conducted: excitatory postsynaptic potential (EPSP) recording, Western blot analysis (cyclic AMP response element-binding (CREB) proteins, phosphorylated CREB proteins, brain-derived neurotrophic factor, and parvalbumin) to examine the synaptic plasticity. The EPSP was remarkably increased in the AD-T group compared with in the AD-NT group. In the Western blot analysis, the differences among the groups were not significant. Hence, tACS can affect the long-lasting enhancement of synaptic transmission in mice models of AD.<\/jats:p>","DOI":"10.3390\/brainsci11111532","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T02:43:09Z","timestamp":1637289789000},"page":"1532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Modulation of Long-Term Potentiation by Gamma Frequency Transcranial Alternating Current Stimulation in Transgenic Mouse Models of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"11","author":[{"given":"Won-Hyeong","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-In","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3769-6227","authenticated-orcid":false,"given":"Hyeng-Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Keun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Physical & Rehabilitation Medicine, Regional Cardiocerebrovascular Center, Center for Aging and Geriatrics, Chonnam National University Medical School & Hospital, Gwangju City 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Sung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Physical & Rehabilitation Medicine, Chonnam National University Hospital, Gwangju City 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-8875","authenticated-orcid":false,"given":"Jae-Young","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Physical & Rehabilitation Medicine, Regional Cardiocerebrovascular Center, Center for Aging and Geriatrics, Chonnam National University Medical School & Hospital, Gwangju City 61469, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"P453","DOI":"10.1093\/geronb\/57.5.P453","article-title":"Behavioral change in persons with dementia: Relationships with mental and physical health of caregivers","volume":"57","author":"Hooker","year":"2002","journal-title":"J. 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