{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:35:27Z","timestamp":1767339327277,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["162744, 166704"],"award-info":[{"award-number":["162744, 166704"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Several cortical and sub-cortical regions in the right hemisphere, particularly in parietal and frontal lobe, but also in temporal lobe and thalamus, are part of neural networks critically implicated in spatial and attentional functions. Damage to different sites within these networks can cause hemispatial neglect. The aim of this study was to identify the neural substrates of different spatial processing components that are known to contribute to neglect symptoms. First, three different spatial tasks (visual search, bisection, and visual memory) were tested in 27 patients with focal right brain-damage. Voxel-based lesion\u2013symptom mapping was used to determine the relationships between specific sites of damage and severity of deficits in these three spatial tasks. Secondly, fMRI was used in 26 healthy controls who performed the same tasks. In the healthy group, fMRI results showed a differential activation of regions within the parietal and frontal lobes during bisection and visual search, respectively. In the patients, we confirmed a critical role of right lateral parietal cortex in bisection, but lesions in frontal and temporal lobe were more critical for visual search. These data support the existence of distinct components in spatial attentional processes that might be damaged to different degrees in neglect patients.<\/jats:p>","DOI":"10.3390\/brainsci11121584","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T04:48:37Z","timestamp":1638247717000},"page":"1584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Brain Substrates for Distinct Spatial Processing Components Contributing to Hemineglect in Humans"],"prefix":"10.3390","volume":"11","author":[{"given":"Yann","family":"Cojan","sequence":"first","affiliation":[{"name":"Laboratory for Behavioral Neurology and Imaging of Cognition, Neuroscience Department, University of Geneva, 1211 Geneva, Switzerland"},{"name":"CRIR\/Institut Nazareth et Louis-Braille du CISSS de la Mont\u00e9r\u00e9gie-Centre, Longueuil, QC J4K 5G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Saj","sequence":"additional","affiliation":[{"name":"Laboratory for Behavioral Neurology and Imaging of Cognition, Neuroscience Department, University of Geneva, 1211 Geneva, Switzerland"},{"name":"CRIR\/Institut Nazareth et Louis-Braille du CISSS de la Mont\u00e9r\u00e9gie-Centre, Longueuil, QC J4K 5G4, Canada"},{"name":"Department of Psychology, University of Montr\u00e9al, Montr\u00e9al, QC H3A 1G1, Canada"},{"name":"Neurology Department, Neuropsychology Unit, University Hospital of Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Vuilleumier","sequence":"additional","affiliation":[{"name":"Laboratory for Behavioral Neurology and Imaging of Cognition, Neuroscience Department, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ana.410280502","article-title":"Large-Scale Neurocognitive Networks and Distributed Processing for Attention, Language, and Memory","volume":"28","author":"Mesulam","year":"1990","journal-title":"Ann. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.ne.13.030190.000325","article-title":"The Attention System of the Human Brain","volume":"13","author":"Posner","year":"1990","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of Goal-Directed and Stimulus-Driven Attention in the Brain","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1006\/nimg.1999.0503","article-title":"Neuroanatomic Overlap of Working Memory and Spatial Attention Networks: A Functional MRI Comparison within Subjects","volume":"10","author":"LaBar","year":"1999","journal-title":"NeuroImage"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0896-6273(00)80593-0","article-title":"A Common Network of Functional Areas for Attention and Eye Movements","volume":"21","author":"Corbetta","year":"1998","journal-title":"Neuron"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1146\/annurev-neuro-061010-113731","article-title":"Spatial Neglect and Attention Networks","volume":"34","author":"Corbetta","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/brain\/awp305","article-title":"Neuroanatomy of Hemispatial Neglect and Its Functional Components: A Study Using Voxel-Based Lesion-Symptom Mapping","volume":"133","author":"Verdon","year":"2010","journal-title":"Brain"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1162\/089892902317362029","article-title":"Neural Systems for Visual Orienting and Their Relationships to Spatial Working Memory","volume":"14","author":"Corbetta","year":"2002","journal-title":"J. Cogn. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/brain\/122.6.1093","article-title":"A Large-Scale Distributed Network for Covert Spatial Attention: Further Anatomical Delineation Based on Stringent Behavioural and Cognitive Controls","volume":"122","author":"Gitelman","year":"1999","journal-title":"Brain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/nimg.2001.0951","article-title":"Visual Feature and Conjunction Searches of Equal Difficulty Engage Only Partially Overlapping Frontoparietal Networks","volume":"15","author":"Donner","year":"2002","journal-title":"NeuroImage"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1097\/00001756-200312020-00024","article-title":"Parietal Activation during Visual Search in the Absence of Multiple Distractors","volume":"14","author":"Donner","year":"2003","journal-title":"NeuroReport"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/nimg.2002.1329","article-title":"Brain Activations during Visual Search: Contributions of Search Efficiency versus Feature Binding","volume":"18","author":"Nobre","year":"2003","journal-title":"NeuroImage"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1212\/WNL.54.6.1324","article-title":"Line Bisection Judgments Implicate Right Parietal Cortex and Cerebellum as Assessed by FMRI","volume":"54","author":"Fink","year":"2000","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuroscience.2005.04.070","article-title":"Prefrontal and Parietal Contributions to Spatial Working Memory","volume":"139","author":"Curtis","year":"2006","journal-title":"Neuroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S1053-8119(02)00027-7","article-title":"Comparing Event-Related and Epoch Analysis in Blocked Design FMRI","volume":"18","author":"Mechelli","year":"2003","journal-title":"NeuroImage"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbr.2008.12.005","article-title":"Parcellation of Parietal Cortex: Convergence between Lesion-Symptom Mapping and Mapping of the Intact Functioning Brain","volume":"199","author":"Vandenberghe","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1093\/brain\/awg200","article-title":"The Anatomy of Visual Neglect","volume":"126","author":"Mort","year":"2003","journal-title":"Brain"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cortex.2011.10.009","article-title":"Prism Adaptation Enhances Activity of Intact Fronto-Parietal Areas in Both Hemispheres in Neglect Patients","volume":"49","author":"Saj","year":"2013","journal-title":"Cortex"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/02643294.2010.519699","article-title":"Separating Neural Correlates of Allocentric and Egocentric Neglect: Distinct Cortical Sites and Common White Matter Disconnections","volume":"27","author":"Chechlacz","year":"2010","journal-title":"Cogn. Neuropsychol."},{"key":"ref_20","first-page":"1385","article-title":"Presenting a battery for assessing spatial neglect. Norms and effects of age, educational level, sex, hand and laterality","volume":"157","author":"Rousseaux","year":"2001","journal-title":"Rev. Neurol. (Paris)"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1155\/2000\/421719","article-title":"Stereotaxic Display of Brain Lesions","volume":"12","author":"Rorden","year":"2000","journal-title":"Behav. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/brain\/awq052","article-title":"A Deficit of Spatial Remapping in Constructional Apraxia after Right-Hemisphere Stroke","volume":"133","author":"Russell","year":"2010","journal-title":"Brain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1093\/brain\/awr227","article-title":"\u2018The Anatomy Underlying Acute versus Chronic Spatial Neglect\u2019 Also Depends on Clinical Tests","volume":"135","author":"Saj","year":"2012","journal-title":"Brain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/j.cub.2008.08.072","article-title":"Abnormal Attentional Modulation of Retinotopic Cortex in Parietal Patients with Spatial Neglect","volume":"18","author":"Vuilleumier","year":"2008","journal-title":"Curr. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/neuro.09.007.2009","article-title":"Brain Activity during Landmark and Line Bisection Tasks","volume":"3","author":"Cicek","year":"2009","journal-title":"Front. Hum. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S1053-8119(03)00018-1","article-title":"Are Action and Perception in near and Far Space Additive or Interactive Factors?","volume":"18","author":"Weiss","year":"2003","journal-title":"NeuroImage"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.neuropsychologia.2007.10.024","article-title":"Timing of Visuo-Spatial Information Processing: Electrical Source Imaging Related to Line Bisection Judgements","volume":"46","author":"Waberski","year":"2008","journal-title":"Neuropsychologia"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Vallar, G., Lobel, E., Galati, G., Berthoz, A., Pizzamiglio, L., and Le Bihan, D. (1999). A Fronto-Parietal System for Computing the Egocentric Spatial Frame of Reference in Humans. Exp. Brain Res., 124.","DOI":"10.1007\/s002210050624"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s002210000375","article-title":"The Neural Basis of Egocentric and Allocentric Coding of Space in Humans: A Functional Magnetic Resonance Study","volume":"133","author":"Galati","year":"2000","journal-title":"Exp. Brain Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cortex.2019.04.022","article-title":"Prism Adaptation Effect on Neural Activity and Spatial Neglect Depend on Brain Lesion Site","volume":"119","author":"Saj","year":"2019","journal-title":"Cortex J. Devoted Study Nerv. Syst. Behav."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00221-007-0860-0","article-title":"Involvement of Prefrontal Cortex in Visual Search","volume":"180","author":"Anderson","year":"2007","journal-title":"Exp. Brain Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00221-009-2000-5","article-title":"Overlapping Functional Anatomy for Working Memory and Visual Search","volume":"200","author":"Anderson","year":"2010","journal-title":"Exp. Brain Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Walter, E., and Dassonville, P. (2011). Activation in a Frontoparietal Cortical Network Underlies Individual Differences in the Performance of an Embedded Figures Task. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020742"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0028-3932(97)00034-1","article-title":"Distractor-Dependent Frontal Neglect","volume":"35","author":"Husain","year":"1997","journal-title":"Neuropsychologia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1126\/science.1116251","article-title":"Direct Evidence for a Parietal-Frontal Pathway Subserving Spatial Awareness in Humans","volume":"309","author":"Urbanski","year":"2005","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1212\/01.WNL.0000113730.73031.F4","article-title":"Hemispatial Neglect: Subtypes, Neuroanatomy, and Disability","volume":"62","author":"Buxbaum","year":"2004","journal-title":"Neurology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0028-3932(01)00169-5","article-title":"MRI Brain Scan Analyses and Neuropsychological Profiles of Nine Patients with Persisting Unilateral Neglect","volume":"40","author":"Maguire","year":"2002","journal-title":"Neuropsychologia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0010-9452(08)70004-2","article-title":"Anatomical and Neurological Correlates of Acute and Chronic Visuospatial Neglect Following Right Hemisphere Stroke* *Some of the Results of This Study Were Presented at: The 5th Nordic Meeting in Neuropsychology, Uppsala, Sweden, August 17-19, 1995","volume":"33","author":"Samuelsson","year":"1997","journal-title":"Cortex"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1097\/00001756-200312020-00021","article-title":"The Anatomy of Neglect without Hemianopia: A Key Role for Parietal\u2013Frontal Disconnection?","volume":"14","author":"Doricchi","year":"2003","journal-title":"NeuroReport"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/cercor\/bhl181","article-title":"Left Unilateral Neglect as a Disconnection Syndrome","volume":"17","author":"Bartolomeo","year":"2007","journal-title":"Cereb. Cortex"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6638","DOI":"10.1523\/JNEUROSCI.0625-20.2020","article-title":"Discrete Patterns of Cross-Hemispheric Functional Connectivity Underlie Impairments of Spatial Cognition after Stroke","volume":"40","author":"Ptak","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cortex.2015.12.008","article-title":"Structural White-Matter Connections Mediating Distinct Behavioral Components of Spatial Neglect in Right Brain-Damaged Patients","volume":"77","author":"Vaessen","year":"2016","journal-title":"Cortex"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/12\/1584\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:37:35Z","timestamp":1760168255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/11\/12\/1584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,29]]},"references-count":42,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["brainsci11121584"],"URL":"https:\/\/doi.org\/10.3390\/brainsci11121584","relation":{},"ISSN":["2076-3425"],"issn-type":[{"type":"electronic","value":"2076-3425"}],"subject":[],"published":{"date-parts":[[2021,11,29]]}}}