{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:50:47Z","timestamp":1760403047161,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Recent research has assessed pupil size during past thinking in patients with retrograde amnesia. Building on this research, we assessed pupil size during future thinking in a retrograde amnesia patient. To this end, we measured pupil size during past and future thinking in L, a 19-year-old, right-handed man free of neurological\/psychiatric disorders except for retrograde amnesia that occurred after an episode of fugue. During a past thinking condition, we invited L to retrieve retrograde events (i.e., events that occurred before amnesia) and anterograde events (i.e., events that occurred after amnesia). During a future thinking condition, we invited him to imagine events that might occur the following week, the following month, and in the new year. Past and future thinking occurred while L\u2019s pupil size was monitored with eye-tracking glasses. L demonstrated higher specificity during future than during past thinking. Critically, the results demonstrated a larger pupil size during future than during past thinking. The larger pupil size during future thinking observed in L can be attributed to the high cognitive load involved in future thinking. Our study not only demonstrates preserved future thinking in a patient with dissociative retrograde amnesia, but also shows that pupillometry can be used for the physiological assessment of future thinking in retrograde amnesia patients.<\/jats:p>","DOI":"10.3390\/brainsci12010115","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:44:00Z","timestamp":1642365840000},"page":"115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Increased Pupil Size during Future Thinking in a Subject with Retrograde Amnesia"],"prefix":"10.3390","volume":"12","author":[{"given":"Claire","family":"Boutoleau-Bretonni\u00e8re","sequence":"first","affiliation":[{"name":"CHU de Nantes, Inserm CIC04, 44000 Nantes, France"},{"name":"CHU de Nantes, Department of Neurology, Centre M\u00e9moire de Ressources et Recherche, 44000 Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estelle","family":"Lamy","sequence":"additional","affiliation":[{"name":"CHU de Nantes, Inserm CIC04, 44000 Nantes, France"},{"name":"CHU de Nantes, Department of Neurology, Centre M\u00e9moire de Ressources et Recherche, 44000 Nantes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-7557","authenticated-orcid":false,"given":"Mohamad","family":"El Haj","sequence":"additional","affiliation":[{"name":"Laboratoire de Psychologie des Pays de la Loire, Nantes Universit\u00e9, Univ Angers, 44000 Nantes, France"},{"name":"Unit\u00e9 de G\u00e9riatrie, Centre Hospitalier de Tourcoing, 59200 Tourcoing, France"},{"name":"Institut Universitaire de France, 75000 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.cortex.2012.05.020","article-title":"The impairment of recollection in functional amnesic states","volume":"49","author":"Markowitsch","year":"2013","journal-title":"Cortex"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuropsychologia.2017.10.017","article-title":"Psychological causes of autobiographical amnesia: A study of 28 cases","volume":"110","author":"Staniloiu","year":"2018","journal-title":"Neuropsychologia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1136\/jnnp.56.9.988","article-title":"Retrograde amnesia after traumatic injury of the fronto-temporal cortex","volume":"56","author":"Markowitsch","year":"1993","journal-title":"J. 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