{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:28:26Z","timestamp":1791224906372,"version":"4.1.0"},"reference-count":55,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech Inc","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: The study provides real-world data on the impact of Huntington\u2019s disease (HD) from the perspective of individuals with HD (IHD) and care partners (HD-CP) and contextualizes these results relative to Parkinson\u2019s disease (PD) and the general population (GP). Methods: Cross-sectional survey of IHD and HD-CP in the US (July 2019\u2013August 2019) conducted using the Rare Patient Voice panel. Data for individuals with Parkinson\u2019s Disease (IPD), the general population (GP), and respective care partners (PD-CP; GP-CP) came from the 2018 US National Health and Wellness Survey. Outcomes included demographics, mental health, clinical characteristics, and health-related quality of life (HRQoL). Results: IHD had greater comorbid anxiety (IHD = 51.2%, IPD = 28.8%, GP = 2.0%), and HD-CP had greater comorbid anxiety (HD-CP = 52.5%, PD-CP = 28.6%, GP-CP = 19.6%) and depression (HD-CP = 65.0%, PD-CP = 29.9%, GP-CP = 19.6%), relative to other cohorts (p &lt; 0.05). Respective of their GP cohorts, IHD exhibited lower HRQoL (EQ-5D: 0.66 \u00b1 0.21 vs. 0.81 \u00b1 0.17) and greater depression (PHQ-9: 11.59 \u00b1 7.20 vs. 5.85 \u00b1 6.71), whereas HD-CP exhibited greater depression only (PHQ-9: 6.84 \u00b1 6.38 vs. 4.15 \u00b1 5.58) (p &lt; 0.001). No differences were observed between HD\/HD-CP and PD\/PD-CP cohorts on PHQ-9 or HRQoL. Conclusions: HD has a significant burden on patients and care partners, which is higher than GP. Notably, anxiety and depression were greater among HD vs. PD, despite similar HRQoL.<\/jats:p>","DOI":"10.3390\/brainsci12020161","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T11:02:53Z","timestamp":1643194973000},"page":"161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Understanding the Burdens Associated with Huntington\u2019s Disease in Manifest Patients and Care Partners\u2013Comparing to Parkinson\u2019s Disease and the General Population"],"prefix":"10.3390","volume":"12","author":[{"given":"Alex","family":"Exuzides","sequence":"first","affiliation":[{"name":"Genentech Inc., South San Francisco, CA 94080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-6765","authenticated-orcid":false,"given":"Joana E.","family":"Matos","sequence":"additional","affiliation":[{"name":"Cerner Enviza, North Kansas City, MO 64117, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisha M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Genentech Inc., South San Francisco, CA 94080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4876-1752","authenticated-orcid":false,"given":"Ashley A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Cerner Enviza, North Kansas City, MO 64117, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Ricker","sequence":"additional","affiliation":[{"name":"Cerner Enviza, North Kansas City, MO 64117, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Bega","sequence":"additional","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. 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