{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:44:11Z","timestamp":1764603851470,"version":"build-2065373602"},"reference-count":71,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"publisher","award":["15007"],"award-info":[{"award-number":["15007"]}],"id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center of Integrative Neuroscience","award":["-"],"award-info":[{"award-number":["-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: The locus coeruleus (LC) plays a critical role in modulating emotional memory performance via widespread connections to the medial temporal lobe (MTL). Interestingly, both the LC and MTL are affected during aging. Therefore, we aimed to investigate whether worry during cognitive aging changes the relationship between memory performance and the neural activity patterns during an emotional memory task. Methods: Twenty-eight participants aged 60\u201383 years from the Maastricht Aging study conducted an emotional mnemonic discrimination task during a 7T fMRI-scan. We performed a robust multiple linear regression to examine the association between worry and mnemonic memory performance under different levels of arousal. Subsequently, we examined if worry modifies the relationship between neuronal activity and mnemonic memory performance. Results: We observed that under low arousal, only participants with low compared to high levels of worry benefitted from additional LC activity. Under high arousal, additional LC activity was associated with lower mnemonic memory performance. Conclusion: Our results suggest there might be an optimal involvement of the NA-system for optimal memory discrimination performance, as we observed that under low levels of worry and with lower levels of arousal, higher LC activity might be needed to achieve similar levels of optimal memory performance as achieved under higher arousal when LC activity remained lower.<\/jats:p>","DOI":"10.3390\/brainsci12030381","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T22:29:43Z","timestamp":1647210583000},"page":"381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Worry Modifies the Relationship between Locus Coeruleus Activity and Emotional Mnemonic Discrimination"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1911-5540","authenticated-orcid":false,"given":"Linda H. G.","family":"Pagen","sequence":"first","affiliation":[{"name":"Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands"},{"name":"Centre for Integrative Neuroscience, School for Mental Health and Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8190-4367","authenticated-orcid":false,"given":"Benedikt A.","family":"Poser","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin P. J.","family":"van Boxtel","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5661-6670","authenticated-orcid":false,"given":"Nikos","family":"Priovoulos","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1285-9739","authenticated-orcid":false,"given":"Roy W. E.","family":"van Hooren","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans R. J.","family":"Verhey","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-3822","authenticated-orcid":false,"given":"Heidi I. L.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Alzheimer Centre Limburg, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The Netherlands"},{"name":"Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands"},{"name":"Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1037\/a0026187","article-title":"Memory modulation","volume":"125","author":"Roozendaal","year":"2011","journal-title":"Behav. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.27.070203.144157","article-title":"The amygdala modulates the consolidation of memories of emotionally arousing experiences","volume":"27","author":"McGaugh","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.psyneuen.2009.04.020","article-title":"Endogenous noradrenergic activation and memory for emotional material in men and women","volume":"34","author":"Segal","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.nlm.2012.03.010","article-title":"Norepinephrine-mediated emotional arousal facilitates subsequent pattern separation","volume":"97","author":"Segal","year":"2012","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.neuro.28.061604.135709","article-title":"An integrative theory of locus coeruleus-norepinephrine function: Adaptive gain and optimal performance","volume":"28","author":"Cohen","year":"2005","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0173(03)00143-7","article-title":"The locus coeruleus\u2013noradrenergic system: Modulation of behavioral state and state-dependent cognitive processes","volume":"42","author":"Berridge","year":"2003","journal-title":"Brain Res. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.neurobiolaging.2014.10.041","article-title":"Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia","volume":"36","author":"Jacobs","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tics.2016.01.001","article-title":"The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain","volume":"20","author":"Mather","year":"2016","journal-title":"Trends Cogn. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Winklewski, P.J., Radkowski, M., Wszedybyl-Winklewska, M., and Demkow, U. (2017). Stress Response, Brain Noradrenergic System and Cognition. Respiratory System Diseases, Springer.","DOI":"10.1007\/5584_2016_204"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/cne.20723","article-title":"Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance","volume":"493","author":"Cohen","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrn2573","article-title":"The locus coeruleus and noradrenergic modulation of cognition","volume":"10","author":"Sara","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0079-6123(08)63818-2","article-title":"Noradrenergic and locus coeruleus modulation of the perforant path-evoked potential in rat dentate gyrus supports a role for the locus coeruleus in attentional and memorial processes. Neurobiology of the Locus Coeruleus","volume":"88","author":"Harley","year":"1991","journal-title":"Prog. Brain Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0278-5846(87)90015-7","article-title":"A role for norepinephrine in arousal, emotion and learning?: Limbic modulation by norepinephrine and the Kety hypothesis","volume":"11","author":"Harley","year":"1987","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/hipo.22298","article-title":"Pattern separation of emotional information in hippocampal dentate and CA3","volume":"24","author":"Leal","year":"2014","journal-title":"Hippocampus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nlm.2014.02.013","article-title":"Asymmetric effects of emotion on mnemonic interference","volume":"111","author":"Leal","year":"2014","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tins.2011.06.006","article-title":"Pattern separation in the hippocampus","volume":"34","author":"Yassa","year":"2011","journal-title":"Trends Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.tics.2019.08.003","article-title":"Mnemonic Similarity Task: A Tool for Assessing Hippocampal Integrity","volume":"23","author":"Stark","year":"2019","journal-title":"Trends Cogn. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neurobiolaging.2016.08.018","article-title":"Age-related individual variability in memory performance is associated with amygdala-hippocampal circuit function and emotional pattern separation","volume":"49","author":"Leal","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1523\/JNEUROSCI.1956-18.2018","article-title":"Locus Coeruleus Phasic, But Not Tonic, Activation Initiates Global Remapping in a Familiar Environment","volume":"39","author":"Grella","year":"2019","journal-title":"J. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/s41562-019-0715-2","article-title":"Rostral locus coeruleus integrity is associated with better memory performance in older adults","volume":"3","author":"Dahl","year":"2019","journal-title":"Nat. Hum. Behav."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1073\/pnas.1712268115","article-title":"Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events","volume":"115","author":"Callaghan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jalz.2012.01.011","article-title":"Alzheimer\u2019s disease: Pathogenesis and prevention","volume":"8","author":"Braak","year":"2012","journal-title":"Alzheimers Dement."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: Age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/nan.12387","article-title":"Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: The pathological building blocks of early Alzheimer\u2019s disease","volume":"43","author":"Ehrenberg","year":"2017","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1080\/13854046.2016.1190404","article-title":"Everyday functioning and cognitive correlates in healthy older adults with subjective cognitive concerns","volume":"30","author":"McAlister","year":"2016","journal-title":"Clin. Neuropsychol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/1099-1166(200011)15:11<983::AID-GPS238>3.0.CO;2-5","article-title":"Are memory complaints predictive for dementia? A review of clinical and population-based studies","volume":"15","author":"Jonker","year":"2000","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0738-3991(98)00040-8","article-title":"Subjective forgetfulness in a normal Dutch population: Possibilities for health education and other interventions","volume":"34","author":"Commissaris","year":"1998","journal-title":"Patient Educ. Couns."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/geront\/40.5.540","article-title":"Memory complaints, coping, and well-being in old age: A systemic approach","volume":"40","author":"Verhaeghen","year":"2000","journal-title":"Gerontologist"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1176\/appi.psy.44.6.461","article-title":"Relationship of Self-Perceptions of Memory and Worry to Objective Measures of Memory and Cognition in the General Population","volume":"44","author":"Podewils","year":"2003","journal-title":"Psychosomatics"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wolfsgruber, S., Wagner, M., Schmidtke, K., Froelich, L., Kurz, A., Schulz, S.R., Hampel, H., Heuser, I., Peters, O., and Reischies, F.M. (2014). Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100812"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1002\/alz.12163","article-title":"Prediction of dementia of Alzheimer type by different types of subjective cognitive decline","volume":"16","author":"Jessen","year":"2020","journal-title":"Alzheimers Dement."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Heffner, K.L., Quinones, M.M., Gallegos, A.M., Crean, H.F., Lin, F., and Suhr, J.A. (2021). Subjective memory in adults over 50 years of age: Associations with affective and physiological markers of emotion regulation. Aging Ment. Health., 1\u20139.","DOI":"10.1080\/13607863.2021.1904829"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1136\/jnnp.2005.077818","article-title":"Apolipoprotein E epsilon4 and impaired episodic memory in community-dwelling elderly people: A marked sex difference. The Hordaland Health Study","volume":"77","author":"Lehmann","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_34","first-page":"120","article-title":"The Maastricht aging study (MAAS). The longitudinal perspective of cognitive aging","volume":"29","author":"Jolles","year":"1998","journal-title":"Tijdschrift Voor Gerontologie En Geriatrie"},{"key":"ref_35","first-page":"102","article-title":"Computerized health information in The Netherlands: A registration network of family practices","volume":"42","author":"Metsemakers","year":"1992","journal-title":"Br. J. Gen. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"World Medical Association (2013). World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA, 310, 2191\u20132194.","DOI":"10.1001\/jama.2013.281053"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1017\/S1355617705050344","article-title":"Rey\u2019s verbal learning test: Normative data for 1855 healthy participants aged 24\u201381 years and the influence of age, sex, education, and mode of presentation","volume":"11","author":"Jolles","year":"2005","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1080\/13803390591004428","article-title":"The Letter Digit Substitution Test: Normative data for 1858 healthy participants aged 24\u201381 from the Maastricht Aging Study (MAAS): Influence of age, education, and sex","volume":"28","author":"Jolles","year":"2006","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/1073191105283427","article-title":"The Stroop color-word test: Influence of age, sex, and education; and normative data for a large sample across the adult age range","volume":"13","author":"Jolles","year":"2006","journal-title":"Assessment"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1037\/1040-3590.18.4.424","article-title":"The concept shifting test: Adult normative data","volume":"18","author":"Jolles","year":"2006","journal-title":"Psychol. Assess."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","article-title":"A Rating Scale for Depression","volume":"23","author":"Hamilton","year":"1960","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1037\/0882-7974.11.2.324","article-title":"The Abridged Dutch Metamemory in Adulthood (MIA) Questionnaire: Structure and effects of age, sex, and education","volume":"11","author":"Ponds","year":"1996","journal-title":"Psychol. Aging"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7416","DOI":"10.1523\/JNEUROSCI.1001-06.2006","article-title":"The locus ceruleus is involved in the successful retrieval of emotional memories in humans","volume":"26","author":"Sterpenich","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_45","unstructured":"Lang, P.J., Bradley, M.M., and Cuthbert, B.N. (2008). International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual, University of Florida. Technical Report A-8."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/hipo.22087","article-title":"Assessing recollection and familiarity of similar lures in a behavioral pattern separation task","volume":"23","author":"Kim","year":"2013","journal-title":"Hippocampus"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/(SICI)1097-0193(1999)8:2\/3<109::AID-HBM7>3.0.CO;2-W","article-title":"Optimal experimental design for event-related fMRI","volume":"8","author":"Dale","year":"1999","journal-title":"Hum. Brain Mapp."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3758\/BRM.42.3.671","article-title":"Controlling low-level image properties: The SHINE toolbox","volume":"42","author":"Willenbockel","year":"2010","journal-title":"Behav. Res. Methods"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.neuroimage.2009.10.002","article-title":"MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field","volume":"49","author":"Marques","year":"2010","journal-title":"Neuroimage"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neuroimage.2017.07.045","article-title":"High-resolution in vivo imaging of human locus coeruleus by Magnetization Transfer MRI at 3T and 7T","volume":"168","author":"Priovoulos","year":"2017","journal-title":"Neuroimage"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/mrm.22361","article-title":"Multiband multislice GE-EPI at 7 tesla, with 16-fold acceleration using partial parallel imaging with application to high spatial and temporal whole-brain fMRI","volume":"63","author":"Moeller","year":"2010","journal-title":"Magn. Reson. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/mrm.23097","article-title":"Blipped-controlled aliasing in parallel imaging for simultaneous multislice echo planar imaging with reduced g-factor penalty","volume":"67","author":"Setsompop","year":"2012","journal-title":"Magn. Reson. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3389\/fnhum.2013.00623","article-title":"Physiological noise in brainstem FMRI","volume":"7","author":"Brooks","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/nimg.1998.0396","article-title":"Cortical surface-based analysis: II: Inflation, flattening, and a surface-based coordinate system","volume":"9","author":"Fischl","year":"1999","journal-title":"Neuroimage"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroimage.2015.04.042","article-title":"A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI","volume":"115","author":"Iglesias","year":"2015","journal-title":"Neuroimage"},{"key":"ref_56","first-page":"1","article-title":"Advanced normalization tools (ANTS)","volume":"2","author":"Avants","year":"2009","journal-title":"Insight J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved Optimization for the Robust and Accurate Linear Registration and Motion Correction of Brain Images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"NeuroImage"},{"key":"ref_58","unstructured":"R Core Team (2016). R: A Language and Environment for Statistical Computing [Computer Software Manual], R Core Team."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. Ser. B (Methodol.)"},{"key":"ref_60","unstructured":"United Nations Educational Service, and Cultural Organization PDoSoE (1976). International Standard Classification of Education (ISCED): ERIC Clearinghouse, Available online: https:\/\/www.ubos.org\/wp-content\/uploads\/publications\/03_2018International_Standard_Classification_of_Education__March_1976.pdf."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e52059","DOI":"10.7554\/eLife.52059","article-title":"Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm","volume":"9","author":"Jacobs","year":"2020","journal-title":"eLife"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0165-0173(01)00080-7","article-title":"Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systems","volume":"38","author":"Petrovich","year":"2001","journal-title":"Brain Res. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fncir.2017.00086","article-title":"From Structure to Behavior in Basolateral Amygdala-Hippocampus Circuits","volume":"11","author":"Yang","year":"2017","journal-title":"Front. Neural Circuits"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/hipo.23073","article-title":"Transient hippocampal CA1 lesions in humans impair pattern separation performance","volume":"29","author":"Hanert","year":"2019","journal-title":"Hippocampus"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1037\/bne0000011","article-title":"Effects of aging on mnemonic discrimination of emotional information","volume":"128","author":"Leal","year":"2014","journal-title":"Behav. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/1754073908100432","article-title":"Remembering the details: Effects of emotion","volume":"1","author":"Kensinger","year":"2009","journal-title":"Emot. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1101\/lm.048967.118","article-title":"Development of a mnemonic discrimination task using naturalistic stimuli with applications to aging and preclinical Alzheimer\u2019s disease","volume":"26","author":"Leal","year":"2019","journal-title":"Learn. Mem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.paid.2010.08.019","article-title":"New perspectives in attentional control theory","volume":"50","author":"Eysenck","year":"2011","journal-title":"Personal. Individ. Differ."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1007\/s00429-020-02153-z","article-title":"Unraveling the contributions to the neuromelanin-MRI contrast","volume":"225","author":"Priovoulos","year":"2020","journal-title":"Brain Struct. Funct."},{"key":"ref_70","first-page":"130","article-title":"Trigeminal, Visceral and Vestibular Inputs May Improve Cognitive Functions by Acting through the Locus Coeruleus and the Ascending Reticular Activating System: A New Hypothesis","volume":"11","author":"Cataldo","year":"2017","journal-title":"Front. Neuroanat."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"749444","DOI":"10.3389\/fnsys.2021.749444","article-title":"Chewing and Cognitive Improvement: The Side Matters","volume":"15","author":"Cataldo","year":"2021","journal-title":"Front. Syst. 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