{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:49:03Z","timestamp":1789584543331,"version":"build-2803163510"},"reference-count":33,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"joint grant of RFBR, Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science","award":["20-415-242905"],"award-info":[{"award-number":["20-415-242905"]}]},{"name":"Krasnoyarsk Territory and Krasnoyarsk Regional Fund of Science","award":["\u201cArctic\u201d \u2116636"],"award-info":[{"award-number":["\u201cArctic\u201d \u2116636"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Memantine is an FDA approved drug for the treatment of Alzheimer\u2019s disease. It reduces neurodegeneration in the hippocampus and cerebral cortex through the inhibition of extrasynaptic NMDA receptors in patients and mouse models. Potentially, it could prevent neurodegeneration in other brain areas and caused by other diseases. We previously used memantine to prevent functional damage and to retain morphology of cerebellar neurons and Bergmann glia in an optogenetic mouse model of spinocerebellar ataxia type-1 (SCA1). However, before suggesting wider use of memantine in clinics, its side effects must be carefully evaluated. Blockers of NMDA receptors are controversial in terms of their effects on anxiety. Here, we investigated the effects of chronic application of memantine over 9 weeks to CD1 mice and examined rotarod performance and anxiety-related behaviors. Memantine-treated mice exhibited an inability to adapt to anxiety-causing conditions which strongly affected their rotarod performance. A tail suspension test revealed increased signs of behavioral despair. These data provide further insights into the potential deleterious effects of memantine which may result from the lack of adaptation to novel, stressful conditions. This effect of memantine may affect the results of tests used to assess motor performance and should be considered during clinical trials of memantine in patients.<\/jats:p>","DOI":"10.3390\/brainsci12040495","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T21:33:42Z","timestamp":1649885622000},"page":"495","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Memantine Disrupts Motor Coordination through Anxiety-like Behavior in CD1 Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Anton N.","family":"Shuvaev","sequence":"first","affiliation":[{"name":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenetsky, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga S.","family":"Belozor","sequence":"additional","affiliation":[{"name":"Research Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk State Medical University Named after Prof. V.F. Voino-Yasenetsky, 660022 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5427-1688","authenticated-orcid":false,"given":"Oleg I.","family":"Mozhei","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra G.","family":"Mileiko","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila D.","family":"Mosina","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina V.","family":"Laletina","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilia G.","family":"Mikhailov","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana V.","family":"Fritsler","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3887-1413","authenticated-orcid":false,"given":"Andrey N.","family":"Shuvaev","sequence":"additional","affiliation":[{"name":"Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja G.","family":"Teschemacher","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol BS8 1TD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Kasparov","sequence":"additional","affiliation":[{"name":"Institute of Living Systems, Immanuel Kant Baltic Federal University, 236041 Kaliningrad, Russia"},{"name":"Department of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol BS8 1TD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1098\/rstb.2005.1765","article-title":"Ca2+ signals and death programmes in neurons","volume":"360","author":"Berliocchi","year":"2005","journal-title":"Philos. 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