{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:36:42Z","timestamp":1769837802730,"version":"3.49.0"},"reference-count":74,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U54MH091657"],"award-info":[{"award-number":["1U54MH091657"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000913","name":"James S. McDonnell Foundation","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100000913","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Having a parent with Alzheimer\u2019s disease (AD) and related dementias confers a risk for developing these types of neurocognitive disorders in old age, but the mechanisms underlying this risk are understudied. Although the hippocampus is often one of the earliest brain regions to undergo change in the AD process, we do not know how early in the lifespan such changes might occur or whether they differ early in the lifespan as a function of family history of AD. Using a rare sample, young adults with a parent with late-onset dementia, we investigated whether brain abnormalities could already be detected compared with a matched sample. Moreover, we employed simple yet novel techniques to characterize resting brain activity (mean and standard deviation) and brain volume in the hippocampus. Young adults with a parent with dementia showed greater resting mean activity and smaller volumes in the left hippocampus compared to young adults without a parent with dementia. Having a parent with AD or a related dementia was associated with early aberrations in brain function and structure. This early hippocampal dysfunction may be due to aberrant neural firing, which may increase the risk for a diagnosis of dementia in old age.<\/jats:p>","DOI":"10.3390\/brainsci12040496","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T21:33:42Z","timestamp":1649885622000},"page":"496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Young Adults with a Parent with Dementia Show Early Abnormalities in Brain Activity and Brain Volume in the Hippocampus: A Matched Case-Control Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0907-8931","authenticated-orcid":false,"given":"Ian M.","family":"McDonough","sequence":"first","affiliation":[{"name":"Department of Psychology, The University of Alabama, 505 Hackberry Lane, P.O. Box 870348, Tuscaloosa, AL 35487, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Mayhugh","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of Alabama, 505 Hackberry Lane, P.O. Box 870348, Tuscaloosa, AL 35487, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Katherine","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of Alabama, 505 Hackberry Lane, P.O. Box 870348, Tuscaloosa, AL 35487, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikenzi B.","family":"Brasfield","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of Alabama, 505 Hackberry Lane, P.O. Box 870348, Tuscaloosa, AL 35487, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Letang","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of Alabama, 505 Hackberry Lane, P.O. Box 870348, Tuscaloosa, AL 35487, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3228-6501","authenticated-orcid":false,"given":"Christopher R.","family":"Madan","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Nottingham, Nottingham NG7 2RD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2563-4996","authenticated-orcid":false,"given":"Rebecca S.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Psychology, The University of Alabama, 505 Hackberry Lane, P.O. Box 870348, Tuscaloosa, AL 35487, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.neurobiolaging.2013.01.001","article-title":"Changes in subcortical structures in early- versus late-onset Alzheimer\u2019s disease","volume":"34","author":"Cho","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"111cm33","DOI":"10.1126\/scitranslmed.3002609","article-title":"Testing the right target and right drug at the right stage","volume":"3","author":"Sperling","year":"2011","journal-title":"Sci Transl. 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