{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:42:17Z","timestamp":1792590137384,"version":"4.5.0"},"reference-count":81,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Perinatal brain injury occurs in 5.14\/1000 live births in England. A significant proportion of these injuries result from hypoxic ischaemic encephalopathy (HIE) in term infants and intracranial haemorrhage (IVH) or periventricular leukomalacia (PVL) in preterm infants. Standardised care necessitates minimal handling from parents and professionals to reduce the progression of injury. This can potentially increase parental stress through the physical inability to bond with their baby. Recent research highlights the ability of music therapy (MT) to empower parental bonding without handling, through sharing culturally informed personal music with their infant. This review therefore aimed to systematically evaluate the use of MT with infants diagnosed with perinatal brain injury in a neonatal intensive care unit (NICU). Search terms were combined into three categories (audio stimulation (MT), population (neonates) and condition (brain injury), and eight electronic databases were used to identify relevant studies following PRISMA guidelines. Eleven studies using music or vocal stimulation with infants diagnosed with perinatal brain injury were identified and quality assessed using Cochrane ROB2, the ROBINSI Tool and the Newcastle Ottawa Scale. Studies used either voice as live (n = 6) or pre-recorded (n = 3) interventions or pre-recorded instrumental music (n = 2). Studies had two primary areas of focus: developmental outcomes and physiological effects. Results suggested the use of music interventions led to a reduction of infants\u2019 pain scores during procedures and cardiorespiratory events, improved feeding ability (increase oral feeding rate, volume intake and feeds per day) and resulted in larger amygdala volumes than control groups. Additionally, MT intervention on the unit supported long-term hospitalised infants in the acquisition of developmental milestones. Vocal soothing was perceived to be an accessible intervention for parents. However, infants with PVL showed signs of stress in complex interventions, which also potentially resulted in an increase in maternal anxiety in one study. MT with infants diagnosed with perinatal brain injury can have positive effects on infants\u2019 behavioural and neurological parameters and support parental involvement in their infants\u2019 developmental care. Further feasibility studies are required using MT to determine appropriate outcome measures for infants and the support required for parents to allow future comparison in large-scale randomised control trials.<\/jats:p>","DOI":"10.3390\/brainsci12050578","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T16:49:57Z","timestamp":1651250997000},"page":"578","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Role of Music Therapy with Infants with Perinatal Brain Injury"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6463-7113","authenticated-orcid":false,"given":"Kirsty","family":"Ormston","sequence":"first","affiliation":[{"name":"Noah\u2019s Ark Children\u2019s Hospice, University College Hospital London, London EN5 4NP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5118-7878","authenticated-orcid":false,"given":"Rachel","family":"Howard","sequence":"additional","affiliation":[{"name":"Institute for Women\u2019s Health, University College, London WC1E 6HU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Institute for Women\u2019s Health, University College, London WC1E 6HU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4304-4594","authenticated-orcid":false,"given":"Subhabrata","family":"Mitra","sequence":"additional","affiliation":[{"name":"Institute for Women\u2019s Health, University College, London WC1E 6HU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Jaschke","sequence":"additional","affiliation":[{"name":"University Medical Centre Groningen, ArtEZ University of the Arts, 6812 CE Arnhem, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F301","DOI":"10.1136\/archdischild-2017-313707","article-title":"Neonatal brain injuries in England: Population-based incidence derived from routinely recorded clinical data held in the National Neonatal Research Database","volume":"103","author":"Gale","year":"2017","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Marx, V., and Nagy, E. (2015). Fetal Behavioural Responses to Maternal Voice and Touch. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129118"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpsychires.2013.10.009","article-title":"Attentional and executive functions are differentially affected by post-traumatic stress disorder and trauma","volume":"48","author":"Flaks","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1943862109338370","article-title":"PATTERNS\u2014A Model for Evaluating Trauma in NICU Music Therapy: Part 1\u2014Theory and Design","volume":"1","author":"Stewart","year":"2009","journal-title":"Music Med."},{"key":"ref_5","unstructured":"PEEPS-HIE (2022, January 18). What Is HIE. Available online: https:\/\/www.peeps-hie.org\/what-is-hie\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1212\/CON.0000000000000557","article-title":"Hypoxic-Ischemic Encephalopathy and Other Neonatal Encephalopathies","volume":"24","author":"Glass","year":"2018","journal-title":"Contin. Lifelong Learn. Neurol."},{"key":"ref_7","unstructured":"Gale, C.S., Jawad, S.E., Uthaya, S., and Modi, N. (2017). Brain Injury Occurring during or Soon after Birth: A Repost for the National Maternity Ambition Commissioned by the Department of Health, National Data Analysis Unit."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Gotardo, J.W., Volkmer, N.D.F.V., Stangler, G.P., Dornelles, A.D., Bohrer, B.B.D.A., and Carvalho, C.G. (2019). Impact of peri-intraventricular haemorrhage and periventricular leukomalacia in the neurodevelopment of preterms: A systematic review and meta-analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0223427"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.thromres.2010.10.003","article-title":"New insights (and new interrogations) in perinatal arterial ischemic stroke","volume":"127","author":"Chabrier","year":"2011","journal-title":"Thromb. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.nbd.2015.09.011","article-title":"Perinatal brain damage: The term infant","volume":"92","author":"Hagberg","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/bmjqs-2015-IHIabstracts.17","article-title":"Reducing Intraventricular Hemorrhage in a Level III Neonatal Intensive Care Unit","volume":"24","author":"Christ","year":"2015","journal-title":"BMJ Qual. Saf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.srhc.2019.03.004","article-title":"Parental participation during therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy","volume":"20","author":"Biskop","year":"2019","journal-title":"Sex. Reprod. Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/j.1365-2648.2004.03336.x","article-title":"Measuring neonatal intensive care unit-related parental stress","volume":"49","author":"Franck","year":"2005","journal-title":"J. Adv. Nurs."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.earlhumdev.2017.12.008","article-title":"Parent participation in the neonatal intensive care unit: Predictors and relationships to neurobehavior and developmental outcomes","volume":"117","author":"Pineda","year":"2017","journal-title":"Early Hum. Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12887-019-1838-3","article-title":"Comparison of family centered care with family integrated care and mobile technology (mFICare) on preterm infant and family outcomes: A multi-site quasi-experimental clinical trial protocol","volume":"19","author":"Franck","year":"2019","journal-title":"BMC Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/08098131.2016.1205650","article-title":"Family-centred music therapy with preterm infants and their parents in the Neonatal Intensive Care Unit (NICU) in Colombia\u2014A mixed-methods study","volume":"26","author":"Ettenberger","year":"2016","journal-title":"Nord. J. Music Ther."},{"key":"ref_17","unstructured":"BAMT (2021, December 22). What Is Music Therapy. Available online: https:\/\/www.bamt.org\/music-therapy\/what-is-music-therapy."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1542\/peds.2012-1367","article-title":"The Effects of Music Therapy on Vital Signs, Feeding, and Sleep in Premature Infants","volume":"131","author":"Loewy","year":"2013","journal-title":"Pediatrics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/08098131.2013.780091","article-title":"Creative music therapy with premature infants: An analysis of video footage","volume":"23","author":"Haslbeck","year":"2013","journal-title":"Nord. J. Music Ther."},{"key":"ref_20","unstructured":"Standley, J.M., and Walworth, D. (2010). Music Therapy with Premature Infants: Research and Developmental Interventions, The American Music Therapy Association, Inc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4103\/ijnmr.IJNMR_50_16","article-title":"Effect of Kangaroo Care Combined with Music on the Mother\u2013premature Neonate Attachment: A Randomized Controlled Trial","volume":"22","author":"Vahdati","year":"2017","journal-title":"Iran. J. Nurs. Midwifery Res."},{"key":"ref_22","first-page":"532","article-title":"The effect of music and multimodal stimulation on responses of premature infants in neonatal intensive care","volume":"24","author":"Standley","year":"1999","journal-title":"Pediatr. Nurs."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e20160971","DOI":"10.1542\/peds.2016-0971","article-title":"Music Therapy for Preterm Infants and Their Parents: A Meta-analysis","volume":"138","author":"Bieleninik","year":"2016","journal-title":"Pediatrics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102171","DOI":"10.1016\/j.nicl.2020.102171","article-title":"Creative music therapy to promote brain function and brain structure in preterm infants: A randomized controlled pilot study","volume":"25","author":"Haslbeck","year":"2020","journal-title":"NeuroImage: Clin."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.47513\/mmd.v13i2.813","article-title":"Neonatal music therapy and cerebral oxygenation in extremely and very preterm infants: A pilot study","volume":"13","author":"Kooi","year":"2021","journal-title":"Music. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/1943862113495062","article-title":"Electroencephalography and Music Therapy: On the Same Wavelength?","volume":"5","author":"Fachner","year":"2013","journal-title":"Music Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1136\/archdischild-2020-320655","article-title":"Health of mothers of children with a life-limiting condition: A comparative cohort study","volume":"106","author":"Fraser","year":"2021","journal-title":"Arch. Dis. Child."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1076\/chin.8.4.296.13505","article-title":"The Relationship Between Parental Report on the BRIEF and Performance-Based Measures of Executive Function in Children with Moderate to Severe Traumatic Brain Injury","volume":"8","author":"Vriezen","year":"2002","journal-title":"Child Neuropsychol."},{"key":"ref_29","first-page":"105906","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_30","first-page":"D142","article-title":"Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_31","unstructured":"Higgins, J.S.J., Page, M.J., and Sterne, J.A.C. (2021, December 31). Revised Cochrane Risk of Bias Tool. Available online: https:\/\/www.riskofbias.info\/welcome\/rob-2-0-tool\/current-version-of-rob-2."},{"key":"ref_32","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2021, December 31). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in Meta-Analysis. Available online: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/14767058.2010.512185","article-title":"Simulation of prenatal maternal sounds in NICU incubators: A pilot safety and feasibility study","volume":"23","author":"Panagiotidis","year":"2010","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1038\/sj.jp.7200444","article-title":"Sound and the Developing Infant in the NICU: Conclusions and Recommendations for Care","volume":"20","author":"Graven","year":"2000","journal-title":"J. Perinatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1542\/peds.2013-2547","article-title":"A Pacifier-Activated Music Player With Mother\u2019s Voice Improves Oral Feeding in Preterm Infants","volume":"133","author":"Chorna","year":"2014","journal-title":"Pediatrics"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1111\/apa.13944","article-title":"Randomised study showed that recorded maternal voices reduced pain in preterm infants undergoing heel lance procedures in a neonatal intensive care unit","volume":"106","author":"Chirico","year":"2017","journal-title":"Acta Paediatr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.3109\/14767058.2011.648237","article-title":"Exposure to biological maternal sounds improves cardiorespiratory regulation in extremely preterm infants","volume":"25","author":"Doheny","year":"2012","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"fmab009","DOI":"10.1093\/tropej\/fmab009","article-title":"Effect of Music on Outcomes of Birth Asphyxia: A Randomized Controlled Trial","volume":"67","author":"Konar","year":"2021","journal-title":"J. Trop. Pediatr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/jp.2009.185","article-title":"Validity and reliability of the N-PASS assessment tool with acute pain","volume":"30","author":"Hummel","year":"2009","journal-title":"J. Perinatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00002508-199603000-00004","article-title":"Premature Infant Pain Profile: Development and Initial Validation","volume":"12","author":"Stevens","year":"1996","journal-title":"Clin. J. Pain"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"F81","DOI":"10.1136\/fn.71.2.F81","article-title":"Development of fetal hearing","volume":"71","author":"Hepper","year":"1994","journal-title":"Arch. Dis. Childhood. Fetal Neonatal Ed."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/08098131.2011.648653","article-title":"Music therapy for premature infants and their parents: An integrative review","volume":"21","author":"Haslbeck","year":"2012","journal-title":"Nord. J. Music Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.aip.2018.03.001","article-title":"Music therapy song writing with mothers of preterm babies in the Neonatal Intensive Care Unit (NICU)\u2014A mixed-methods pilot study","volume":"58","author":"Ettenberger","year":"2018","journal-title":"Arts Psychother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1007\/s00431-020-03890-3","article-title":"Preterm infants with severe brain injury demonstrate unstable physiological responses during maternal singing with music therapy: A randomized controlled study","volume":"180","author":"Epstein","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1177\/0884217504263289","article-title":"Developmental Patterns of Physiological Response to a Multisensory Intervention in Extremely Premature and High-Risk Infants","volume":"33","author":"Nelson","year":"2004","journal-title":"J. Obstet. Gynecol. Neonatal Nurs."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"116391","DOI":"10.1016\/j.neuroimage.2019.116391","article-title":"Music enhances structural maturation of emotional processing neural pathways in very preterm infants","volume":"207","author":"Lordier","year":"2020","journal-title":"Neuroimage"},{"key":"ref_47","unstructured":"Haith, M.M., and Benson, J.B. (2008). Bayley Scales of Infant Development. Encyclopedia of Infant and Early Childhood Development, Academic Press."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/00006199-198707000-00015","article-title":"An instrument for the measurement of infant-adult synchrony","volume":"36","author":"Censullo","year":"1987","journal-title":"Nurs. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/00006199-199305000-00005","article-title":"Parental Stressor Scale: Neonatal intensive care unit","volume":"42","author":"Miles","year":"1993","journal-title":"Nurs. Res."},{"key":"ref_50","unstructured":"Speilberger, C.D. (1983). Manual for the State-Trait Anxiety Inventory (STAI), Consulting Physchologists Press."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kraft, K., Jaschke, A., Ravensbergen, A.-G., Feenstra-Weelink, A., van Goor, M., de Kroon, M., Reijneveld, S., Bos, A., and van Dokkum, N. (2021). Maternal Anxiety, Infant Stress, and the Role of Live-Performed Music Therapy during NICU Stay in The Netherlands. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18137077"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/apa.14628","article-title":"A randomised controlled trial of protocolised music therapy demonstrates developmental milestone acquisition in hospitalised infants","volume":"108","author":"Emery","year":"2018","journal-title":"Acta Paediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.1097\/ANC.0000000000000786","article-title":"A Maternal-Administered Multimodal Neonatal Bundle in Hospitalized Very Preterm Infants: A Pilot Study","volume":"21","author":"Letzkus","year":"2021","journal-title":"Adv. Neonatal Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/088307380101600706","article-title":"One-year outcome of auditory-tactile-visual vestibular intervention in the neonatal intensive care unit: Effects of severe prematurity and central nervous system injury","volume":"16","author":"Nelson","year":"2001","journal-title":"J. Child Neurol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1098-240X(199904)22:2<131::AID-NUR5>3.0.CO;2-E","article-title":"Developmental intervention for preterm infants diagnosed with periventricular leukomalacia","volume":"22","author":"Nelson","year":"1999","journal-title":"Res. Nurs. Health"},{"key":"ref_56","unstructured":"Yasin, F., Women, C., and Infants University Hospital (2022, January 18). Effect of Mozart Music on Cerebral Oxygenation and Behavioural Response of Premature Infants (July 2014\u2013July 2015) Identifier NCT02471482, Available online: https:\/\/clinicaltrials.gov\/show\/NCT02471482."},{"key":"ref_57","unstructured":"Shokri, E. (2022, January 18). Effect If PIOMI Combine with Music Therapy on Feeding of Premature Infants, Identifier IRCT20210502051155N1. Available online: http:\/\/en.irct.ir\/trial\/56003."},{"key":"ref_58","unstructured":"Sgobbi, B., and di Circolo, O. (2022, January 18). The Effects of Recorded Music Therapy on Oral Nutrition and the Well-Being of the Italian Premature Baby: Prosepective Randomized Controlled Study Mom, Dad and Music Therapist Singing Voice. (August 2020\u2013February 2021) Identifier: NCT04759170, Available online: https:\/\/clinicaltrials.gov\/show\/NCT04759170."},{"key":"ref_59","unstructured":"Meir Medical Center (2022, January 18). The Combined Effects of Maternal Singing During Skin to Skin Contact (Kangaroo Care) in Preterm Infants in the Neonatal Care Unit Environment. (November 2011\u2013November 2014) Identifier: NCT01427894, Available online: https:\/\/clinicaltrials.gov\/show\/NCT013427894."},{"key":"ref_60","first-page":"37","article-title":"The effects of maternal voice and biological sounds on nutrition and respiratory outcomes in preterm infants","volume":"25","author":"Zimmerman","year":"2012","journal-title":"J. Matern. -Fetal Neonatal Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/s41372-020-0719-9","article-title":"Music therapy and retinopathy of prematurity screening: Using recorded maternal singing and heartbeat for post exam recovery","volume":"40","author":"Corrigan","year":"2020","journal-title":"J. Perinatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e550","DOI":"10.1542\/peds.2013-1447B","article-title":"NIDCAP Federation International response","volume":"132","author":"Lawhon","year":"2013","journal-title":"Pediatrics"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.3389\/fneur.2021.649340","article-title":"Evaluation of the Short-Term Music Therapy on Brain Functions of Preterm Infants Using Functional Near-Infrared Spectroscopy","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Giordano, V., Goeral, K., Schrage-Leitner, L., Berger, A., and Olischar, M. (2021). The Effect of Music on aEEG Cyclicity in Preterm Neonates. Children, 8.","DOI":"10.3390\/children8030208"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0378-3782(91)90017-W","article-title":"Detectability of auditory evoked response components in preterm infants","volume":"26","author":"Pasman","year":"1991","journal-title":"Early Hum. Dev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1467-7687.2004.00379.x","article-title":"Maturation of fetal responses to music","volume":"7","author":"Kisilevsky","year":"2004","journal-title":"Dev. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Partanen, E., Kujala, T., Tervaniemi, M., and Huotilainen, M. (2013). Prenatal Music Exposure Induces Long-Term Neural Effects. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078946"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/867531","article-title":"Sex Differences in Mechanisms and Outcome of Neonatal Hypoxia-Ischemia in Rodent Models: Implications for Sex-Specific Neuroprotection in Clinical Neonatal Practice","volume":"2012","author":"Hill","year":"2012","journal-title":"Neurol. Res. Int."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Harding, C., Whiting, L., Petty, J., Edney, S., Murphy, R., and Crossley, S.-L. (2022). Infant communication. How should we define this, and is it important?. J. Neonatal Nurs.","DOI":"10.1016\/j.jnn.2022.01.006"},{"key":"ref_70","first-page":"e60412","article-title":"Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit","volume":"155","author":"Haslbeck","year":"2020","journal-title":"J. Vis. Exp."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrn3666","article-title":"Brain correlates of music-evoked emotions","volume":"15","author":"Koelsch","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jpeds.2013.08.047","article-title":"Alterations in Brain Structure and Neurodevelopmental Outcome in Preterm Infants Hospitalized in Different Neonatal Intensive Care Unit Environments","volume":"164","author":"Pineda","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/3972918","article-title":"Neuroprocessing Mechanisms of Music during Fetal and Neonatal Development: A Role in Neuroplasticity and Neurodevelopment","volume":"2019","author":"Chorna","year":"2019","journal-title":"Neural Plast."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Kehl, S.M., Marca-Ghaemmaghami, L., Haller, M., Pichler-Stachl, E., Bucher, H.U., Bassler, D., and Haslbeck, F.B. (2020). Depressive Symptoms and Parent-Creative Music Therapy with Premature Infants and Their Parents: A Mixed-Method Pilot Study on Parents\u2019 Anxiety, Stress and Infant Attachment. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18010265"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Roa, E., and Ettenberger, M. (2018). Music Therapy Self-Care Group for Parents of Preterm Infants in the Neonatal Intensive Care Unit: A Clinical Pilot Intervention. Medicines, 5.","DOI":"10.20944\/preprints201811.0433.v1"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/apa.12744","article-title":"Maternal singing during kangaroo care led to autonomic stability in preterm infants and reduced maternal anxiety","volume":"103","author":"Arnon","year":"2014","journal-title":"Acta Paediatr."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Kobus, S., Diezel, M., Huening, B., Dewan, M.V., Felderhoff-Mueser, U., and Bruns, N. (2021). Parents\u2019 Perception of Family-Centered Music Therapy with Stable Preterm Infants. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182312813"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Span, L., van Dokkum, N., Ravensbergen, A.-G., Bos, A., and Jaschke, A. (2021). Combining Kangaroo Care and Live-Performed Music Therapy: Effects on Physiological Stability and Neurological Functioning in Extremely and Very Preterm Infants. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18126580"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/mtp\/mix004","article-title":"Time Together: A Feasible Program to Promote parent-infant Interaction in the NICU","volume":"36","author":"Shoemark","year":"2017","journal-title":"Music Ther. Perspect."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e025062","DOI":"10.1136\/bmjopen-2018-025062","article-title":"Longitudinal Study of music Therapy\u2019s Effectiveness for Premature infants and their caregivers (LongSTEP): Protocol for an international randomised trial","volume":"9","author":"Ghetti","year":"2019","journal-title":"BMJ Open"},{"key":"ref_81","unstructured":"Malloch, S., and Trevarthen, C. (2010). Communicative Musicality: Exploring the Basis of Human Companionship, Oxford University Press."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/5\/578\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:04:11Z","timestamp":1760137451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/5\/578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,29]]},"references-count":81,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["brainsci12050578"],"URL":"https:\/\/doi.org\/10.3390\/brainsci12050578","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,29]]}}}