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Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and\/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and\/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.<\/jats:p>","DOI":"10.3390\/brainsci12050588","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T06:23:08Z","timestamp":1651386188000},"page":"588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sex Differences in Plasma Lysophosphatidic Acid Species in Patients with Alcohol and Cocaine Use Disorders"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-1465","authenticated-orcid":false,"given":"Mar\u00eda","family":"Flores-L\u00f3pez","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2014IBIMA, 29590 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-8796","authenticated-orcid":false,"given":"Pedro","family":"Araos","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2014IBIMA, 29590 M\u00e1laga, Spain"},{"name":"Departamento de Psicobiolog\u00eda y Metodolog\u00eda de las Ciencias del Comportamiento, Facultad de Psicolog\u00eda, Universidad de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Requena-Oca\u00f1a","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga\u2014IBIMA, 29590 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","article-title":"LPA receptors: Subtypes and biological actions","volume":"50","author":"Choi","year":"2010","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.neuron.2015.01.009","article-title":"Lysophosphatidic Acid signaling in the nervous system","volume":"85","author":"Yung","year":"2015","journal-title":"Neuron"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1194\/jlr.R046458","article-title":"LPA receptor signaling: Pharmacology, physiology, and pathophysiology","volume":"55","author":"Yung","year":"2014","journal-title":"J. Lipid Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Riaz, A., Huang, Y., and Johansson, S. (2016). G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. Int. J. Mol. 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