{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:00:11Z","timestamp":1773327611923,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Prurigo nodularis (PN) is a dermatological condition characterized by nodular hyperkeratotic lesions mainly on the legs and arms. Asymmetrical PN is a rare dermatological condition often associated with paralysis and stroke. In this paper, we present the case of a 77-year-old woman who developed post-ictal PN which responded to dupilumab, an anti-interleukin-4\/13 drug approved for the management of AD, with an extreme reduction in itch sensation. Dupilumab and other therapies reducing Th2 inflammation may, in the future, become an alternative treatment for post-ictal pruritus\/PN nonresponding to traditional therapies. Of course, larger studies will be necessary to confirm our case\u2019s findings.<\/jats:p>","DOI":"10.3390\/brainsci12050605","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T13:10:26Z","timestamp":1651756226000},"page":"605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Post-Stroke Asymmetric Prurigo Nodularis Responding to Dupilumab Treatment: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"Ilaria","family":"Sammarra","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-1027","authenticated-orcid":false,"given":"Luigi","family":"Bennardo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy"},{"name":"Unit of Dermatology, Mariano Santo Hospital, 87100 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Provenzano","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Mariano Santo Hospital, 87100 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cataldo","family":"Patruno","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Paul","family":"Nistic\u00f2","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1474-4422(18)30217-5","article-title":"Clinical presentation, management, and pathophysiology of neuropathic itch","volume":"17","author":"Steinhoff","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/brain\/awt158","article-title":"The neurology of itch","volume":"137","author":"Dhand","year":"2014","journal-title":"Brain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.det.2018.02.003","article-title":"Prurigo Nodularis and Its Management","volume":"36","author":"Zeidler","year":"2018","journal-title":"Dermatol. 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