{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T02:55:53Z","timestamp":1762052153716,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CIHR Foundation grant","award":["FDN-143212"],"award-info":[{"award-number":["FDN-143212"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Posterior cerebral artery (PCA) territory infarction involving occipital cortical damage can give rise to contralateral homonymous hemianopia. Here, we report two rare cases of patients with lesions in the left hemisphere PCA territory who developed right visuo-spatial neglect. One patient suffered right hemianopia and right visuo-spatial neglect after a stroke that damaged the left primary visual cortex and the callosal splenial fibers. The other unique case is of a patient who had a brain tumor in the posterior cerebral region in the left hemisphere and initially exhibited only right hemianopia that developed into right visuo-spatial neglect after tumor resection that included the splenial fibers. These cases indicate that, as in cases with damage in the right PCA territory, lesions in the left PCA yield visuo-spatial neglect when the damage produces contralateral hemianopia and concomitant disconnection of the splenium of the corpus callosum, which interferes with the arrival of visual inputs from the intact right to the lesioned left hemisphere. These results also emphasize the necessity of sparing the splenial fibers in surgical interventions in patients who exhibit hemianopia.<\/jats:p>","DOI":"10.3390\/brainsci12050640","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T21:46:53Z","timestamp":1652392013000},"page":"640","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Splenial Callosal Disconnection in Right Hemianopic Patients Induces Right Visual-Spatial Neglect"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1230-2770","authenticated-orcid":false,"given":"Francesco","family":"Tomaiuolo","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Messina, Piazza Pugliatti, 1, 98122 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Raffa","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department BIOMORF, University of Messina, Piazza Pugliatti, 1, 98122 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Campana","sequence":"additional","affiliation":[{"name":"Neurorehabilitation Unit, Auxilium Vitae Volterra, Via Borgo San Lazzero 5, 56048 Volterra, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Garufi","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department BIOMORF, University of Messina, Piazza Pugliatti, 1, 98122 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5325-2621","authenticated-orcid":false,"given":"Stefano","family":"Lasaponara","sequence":"additional","affiliation":[{"name":"Department of Psychology, La Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy"},{"name":"Laboratorio di Neuropsicologia dell\u2019Attenzione, Fondazione Santa Lucia IRCCS, Via Ardeatina, 306, 00179 Rome, Italy"},{"name":"Dipartimento di Scienze Umane, Libera Universit\u00e0 Maria Santissima Assunta LUMSA, Via della Traspontina, 21, 00193 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Voci","sequence":"additional","affiliation":[{"name":"Neurorehabilitation Unit, Auxilium Vitae Volterra, Via Borgo San Lazzero 5, 56048 Volterra, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore M.","family":"Cardali","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department BIOMORF, University of Messina, Piazza Pugliatti, 1, 98122 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"German\u00f2","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department BIOMORF, University of Messina, Piazza Pugliatti, 1, 98122 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Doricchi","sequence":"additional","affiliation":[{"name":"Department of Psychology, La Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy"},{"name":"Laboratorio di Neuropsicologia dell\u2019Attenzione, Fondazione Santa Lucia IRCCS, Via Ardeatina, 306, 00179 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Petrides","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC H3A 2B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1097\/00001756-200312020-00021","article-title":"The anatomy of neglect without 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