{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:48:53Z","timestamp":1762325333849,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Pain is a minor problem compared with other Huntington Disease (HD) symptoms. Nevertheless, in HD it is poorly recognized and underestimated. So far, no study evaluated the presence of chronic pain in HD. The aim of this pilot study was to evaluate the presence and features of chronic pain in a cohort of HD gene carriers. An observational cross-sectional study was conducted in a cohort of HD gene carriers compared to not gene carriers (n.134 HD subjects, n.74 not gene mutation carriers). A specific pain interview, alongside a neurological, cognitive and behavioural examination, was performed in order to classify the type of pain, subjective intensity. A significant prevalence of \u201cno Pain\u201d in HD was found, which tended to increase with HD progression and a reduced frequency of pain in the last 3 months. A clear difference was found between manifest and premanifest HD in terms of intensity of pain, which did not change significantly with HD progression; however, a tendency emerges to a progressive reduction. No significant group difference was present in analgesic use, type and the site of pain. These findings could support a lower prevalence of chronic pain in manifest HD. Prevalence and intensity of chronic pain seem directly influenced by the process of neurodegeneration rather than by an incorrect cognitive and emotional functioning.<\/jats:p>","DOI":"10.3390\/brainsci12050676","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T09:18:08Z","timestamp":1653124688000},"page":"676","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lower Prevalence of Chronic Pain in Manifest Huntington\u2019s Disease: A Pilot Observational Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5888-3024","authenticated-orcid":false,"given":"Marianna","family":"Delussi","sequence":"first","affiliation":[{"name":"AOU Policlinico, Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neurosciences and Sense Organs Department, Aldo Moro University, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Sciruicchio","sequence":"additional","affiliation":[{"name":"Children Epilepsy and EEG Center, PO, San Paolo ASL (Azienda Sanitaria Locale), 70019 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6140-9326","authenticated-orcid":false,"given":"Paolo","family":"Taurisano","sequence":"additional","affiliation":[{"name":"AOU Policlinico, Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neurosciences and Sense Organs Department, Aldo Moro University, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-3639","authenticated-orcid":false,"given":"Francesca","family":"Morgante","sequence":"additional","affiliation":[{"name":"Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George\u2019s University of London, London SW17 0RE, UK"},{"name":"Department of Experimental and Clinical Medicine, University of Messina, 98951 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-5133","authenticated-orcid":false,"given":"Elena","family":"Salvatore","sequence":"additional","affiliation":[{"name":"AOU Federico II, Department of Advanced Biomedical Sciences, Universit\u00e0 di Napoli, 80138 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella Pia","family":"Ferrara","sequence":"additional","affiliation":[{"name":"AOU Federico II, Department of Advanced Biomedical Sciences, Universit\u00e0 di Napoli, 80138 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Clemente","sequence":"additional","affiliation":[{"name":"AOU Policlinico, Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neurosciences and Sense Organs Department, Aldo Moro University, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Sorbera","sequence":"additional","affiliation":[{"name":"IRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6567-5373","authenticated-orcid":false,"given":"Marina","family":"de Tommaso","sequence":"additional","affiliation":[{"name":"AOU Policlinico, Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neurosciences and Sense Organs Department, Aldo Moro University, 70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.brainresrev.2008.04.001","article-title":"Magnetic resonance imaging as an approach towards identifying neuropathological biomarkers for Huntington\u2019s disease","volume":"58","author":"Bohanna","year":"2008","journal-title":"Brain Res. 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