{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:22:42Z","timestamp":1782958962558,"version":"3.54.5"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801070"],"award-info":[{"award-number":["81801070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021ZD0204300"],"award-info":[{"award-number":["2021ZD0204300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific and Technological Innovation 2030","award":["81801070"],"award-info":[{"award-number":["81801070"]}]},{"name":"Scientific and Technological Innovation 2030","award":["2021ZD0204300"],"award-info":[{"award-number":["2021ZD0204300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: The selection of the maintenance of general anesthesia may affect the development of postoperative delirium (POD), notably for Parkinson\u2019s disease (PD) patients, due to their lower cognitive reserve. The present study was designed to compare the potential impact of propofol vs. sevoflurane based general anesthesia maintenance methods on the development of POD in PD patients following deep brain stimulation (DBS) surgery. Methods: A total of 125 PD patients who were scheduled to undergo DBS surgery were randomly divided into the propofol (n = 63) and the sevoflurane groups (n = 62). The patients in the two groups randomly received propofol- or sevoflurane-based general anesthesia. The Confusion Assessment Method (CAM) was employed by an investigator who was blinded to the anesthesia regimen and was administered twice per day from postoperative day 1 until discharge. Results: The incidence of POD was 22.22% (14\/63) with propofol anesthesia and 20.97% (13\/62) with sevoflurane anesthesia (p = 0.865). In addition, no difference was noted in the duration and severity of delirium between the propofol and sevoflurane groups. Conclusions: In the present study, propofol- and sevoflurane-based general anesthesia exhibited comparable results with regard to the POD incidence in PD patients undergoing deep brain stimulation surgery.<\/jats:p>","DOI":"10.3390\/brainsci12060689","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T08:41:33Z","timestamp":1653468093000},"page":"689","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Effect of Propofol versus Sevoflurane on Postoperative Delirium in Parkinson\u2019s Disease Patients Undergoing Deep Brain Stimulation Surgery: An Observational Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Yongde","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Beijing Center of Quality Control and Improvement on Clinical Anesthesia, Beijing,100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongsong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Beijing Center of Quality Control and Improvement on Clinical Anesthesia, Beijing,100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Beijing Center of Quality Control and Improvement on Clinical Anesthesia, Beijing,100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tsinghua University Yuquan Hospital, Beijing 100040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengmei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Beijing Center of Quality Control and Improvement on Clinical Anesthesia, Beijing,100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.parkreldis.2021.06.017","article-title":"Long-term effect of bilateral STN-DBS on non-motor symptoms in Parkinson\u2019s disease: A four-year observational, prospective study","volume":"89","author":"Georgiev","year":"2021","journal-title":"Parkinsonism Relat. 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