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It is also referred to as \u201cthe cancer that never dies\u201d. The olfactory ensheathing cell (OEC) is a special glial cell in the nervous system that has a strong supportive function in nerve regeneration. Cell transplantation therapy is a useful treatment modality that we believe can be applied in TN management. In this study, OECs were transplanted into the ligation site of the infraorbital nerve of rats. We found that after the OEC transplantation, mechanical pain threshold in the face of the rats was significantly increased. Western blotting, immunofluorescence assay, and reverse transcription-quantitative polymerase chain reaction were performed on the trigeminal ganglia (TG) of model rats. The results revealed a decrease in the expression of P2X7 receptor (P2X7R) in the trigeminal ganglia. Our findings show that OEC transplantation has a good therapeutic effect on TN in rats, and that can reduce the expression of P2X7R in trigeminal ganglia. Therefore, we think that OEC transplantation may be a suitable treatment for TN.<\/jats:p>","DOI":"10.3390\/brainsci12060706","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T10:05:14Z","timestamp":1653905114000},"page":"706","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Olfactory Ensheathing Cells Alleviate Facial Pain in Rats with Trigeminal Neuralgia by Inhibiting the Expression of P2X7 Receptor"],"prefix":"10.3390","volume":"12","author":[{"given":"Jiafeng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Liao","sequence":"additional","affiliation":[{"name":"The Stomatology Medical College of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baokang","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Medical College of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Lu","sequence":"additional","affiliation":[{"name":"The Queen Mary College of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pnpbp.2012.03.002","article-title":"A novel trigeminal neuropathic pain model: Compression of the trigeminal nerve root produces prolonged nociception in rats","volume":"38","author":"Jeon","year":"2012","journal-title":"Prog. 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