{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:15:52Z","timestamp":1780622152148,"version":"3.54.1"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T00:00:00Z","timestamp":1654387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Israeli Ministry of Science and Technology","award":["3-13719"],"award-info":[{"award-number":["3-13719"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>This study aimed to capture subjective daily functional cognitive decline among patients with Parkinson\u2019s disease. Participants (40\u201379 y; 78 with Parkinson\u2019s disease and 41 healthy matched controls) completed the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS), Parkinson\u2019s Disease Cognitive Functional Rating Scale (CFRS), Daily Living Questionnaire (DLQ), and Time Organisation and Participation Scale (TOPS) questionnaires. Patients with Parkinson\u2019s disease were divided into groups with or without suspected mild cognitive decline according to their scores on the Cognitive Functional (CF) feature, which is based on certain items of the MDS-UPDRS. Significant between-group differences were found in the DLQ and TOPS scores. Significant correlations were found among the questionnaire results, with specific DLQ and TOPS items accounting for 35% of the variance in the CF feature, which correlated with daily cognitive functional states. This study\u2019s results are relevant for detecting subtle deficits in Parkinson\u2019s disease patients suspected of mild cognitive decline, which can affect health and quality of life and relates to risk for later dementia.<\/jats:p>","DOI":"10.3390\/brainsci12060741","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T10:47:11Z","timestamp":1654426031000},"page":"741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Capturing Subjective Mild Cognitive Decline in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-0389","authenticated-orcid":false,"given":"Sara","family":"Rosenblum","sequence":"first","affiliation":[{"name":"Laboratory of Complex Human Activity and Participation (CHAP), Department of Occupational Therapy, Faculty of Social Welfare & Health Sciences, University of Haifa, Haifa 3498838, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-4563","authenticated-orcid":false,"given":"Sonya","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, Ariel University, Ariel 4077603, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariella","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Industrial Engineering, Jerusalem College of Technology, Jerusalem 9372115, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Hassin-Baer","sequence":"additional","affiliation":[{"name":"Movement Disorders Institute, Sheba Medical Centre, Ramat-Gan 5262000, Israel"},{"name":"Department of Neurology, Sheba Medical Centre, Ramat-Gan 5262000, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"ref_1","first-page":"9131474","article-title":"Update on the management of Parkinson\u2019s disease for general neurologists","volume":"2020","author":"Bajenaru","year":"2020","journal-title":"Parkinson\u2019s Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/mds.23823","article-title":"MDS task force on mild cognitive impairment in Parkinson\u2019s disease: Critical review of PDMCI","volume":"26","author":"Litvan","year":"2011","journal-title":"Mov. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/mds.27323","article-title":"Evolution of diagnostic criteria and assessments for Parkinson\u2019s disease mild cognitive impairment","volume":"33","author":"Goldman","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3233\/JPD-130304","article-title":"MDS Study Group on the Validation of PD-MCI Criteria. Parkinson\u2019s disease mild cognitive impairment: Application and validation of the criteria","volume":"4","author":"Geurtsen","year":"2014","journal-title":"J. Parkinsons Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/mds.24893","article-title":"Diagnostic criteria for mild cognitive impairment in Parkinson\u2019s disease: Movement Disorder Society Task Force guidelines","volume":"27","author":"Litvan","year":"2012","journal-title":"Mov. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/mdc3.12969","article-title":"The Montreal Cognitive Assessment: Is it suitable for identifying mild cognitive impairment in Parkinson\u2019s disease?","volume":"7","author":"Rosenblum","year":"2020","journal-title":"Mov. Disord. Clin. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2044-8260.1982.tb01421.x","article-title":"The Cognitive Failures Questionnaire (CFQ) and its correlates","volume":"21","author":"Broadbent","year":"1982","journal-title":"Br. J. Clin. Psychol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.parkreldis.2013.05.007","article-title":"Measuring functional impact of cognitive impairment: Validation of the Parkinson\u2019s disease cognitive functional rating scale","volume":"19","author":"Kulisevsky","year":"2013","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rosenblum, S., Meyer, S., Richardson, A., and Hassin-Baer, S. (2022). Patients\u2019 self-report and handwriting performance features as indicators for suspected mild cognitive impairment in Parkinson\u2019s disease. Sensors, 22.","DOI":"10.3390\/s22020569"},{"key":"ref_10","first-page":"1362053","article-title":"Coping with cognitive impairment in people with Parkinson\u2019s disease and their carers: A qualitative study","volume":"2018","author":"Lawson","year":"2018","journal-title":"Parkinson\u2019s Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00702-019-02003-1","article-title":"Mild cognitive impairment in Parkinson\u2019s disease","volume":"126","author":"Kulisevsky","year":"2019","journal-title":"J. Neural Transm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1002\/mds.27487","article-title":"Validation of a performance-based assessment of cognitive functional ability in Parkinson\u2019s disease","volume":"33","author":"Holden","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3389\/fnagi.2019.00303","article-title":"Parkinson\u2019s disease: Mild cognitive impairment (PD-MCI); a useful summary of update knowledge with a focus on non-pharmacological interventions including physical exercise","volume":"11","author":"Cammisuli","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/mds.22335","article-title":"UPDRS activity of daily living score as a marker of Parkinson\u2019s disease progression","volume":"24","author":"Harrison","year":"2009","journal-title":"Mov. Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1017\/S1041610211002766","article-title":"The process of decline in advanced activities of daily living: A qualitative explorative study in mild cognitive impairment","volume":"24","author":"Gorus","year":"2012","journal-title":"Int. Psychogeriatr."},{"key":"ref_17","unstructured":"World Health Organization (2001). International Classification of Functioning, Disability and Health (ICF), World Health Organization."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12984-016-0204-z","article-title":"Benefits of virtual reality based cognitive rehabilitation through simulated activities of daily living: A randomized controlled trial with stroke patients","volume":"13","author":"Faria","year":"2016","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15453\/2168-6408.1326","article-title":"Development of the Daily Living Questionnaire (DLQ): A factor analysis study","volume":"5","author":"Rosenblum","year":"2017","journal-title":"Open J. Occup. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/09602011.2011.640465","article-title":"Validity and reliability of the Time Organisation and Participation Scale (TOPS)","volume":"22","author":"Rosenblum","year":"2012","journal-title":"Neuropsychol. Rehabil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2190\/LYKR-7VHP-YJEM-MKM2","article-title":"Screening for depression in primary care clinics: The CES-D and the BDI","volume":"20","author":"Zich","year":"1990","journal-title":"Int. J. Psychiatry Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: Onset, progression and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1212\/WNL.0b013e3181fc29c9","article-title":"The MoCA well-suited screen for cognitive impairment in Parkinson disease","volume":"75","author":"MacAskill","year":"2010","journal-title":"Neurology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson\u2019s disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.parkreldis.2015.08.024","article-title":"Mild cognitive impairment in newly diagnosed Parkinson\u2019s disease: A longitudinal prospective study","volume":"21","author":"Santangelo","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s11910-011-0203-1","article-title":"Mild cognitive impairment in Parkinson\u2019s disease","volume":"11","author":"Aarsland","year":"2011","journal-title":"Curr. Neurol. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/1533317510370956","article-title":"Executive functions deficit in Parkinson\u2019s disease with amnestic mild cognitive impairment","volume":"25","author":"Petrova","year":"2010","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1017\/S1355617709090614","article-title":"Cognitive decline in Parkinson\u2019s disease: A prospective longitudinal study","volume":"15","author":"Post","year":"2009","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/089826439100300210","article-title":"Preclinical disability: Hypotheses about the bottom of the iceberg","volume":"3","author":"Fried","year":"1991","journal-title":"J. Aging Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1037\/neu0000045","article-title":"Instrumental activities of daily living are impaired in Parkinson\u2019s disease patients with mild cognitive impairment","volume":"28","author":"Pirogovsky","year":"2014","journal-title":"Neuropsychology"},{"key":"ref_31","unstructured":"Katz, N. (2014). Cognitive information processing. Cognition, Occupation, and Participation across the Life Span: Neuroscience, Neurorehabilitation, and Models of Intervention in Occupational Therapy, AOTA Press."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.parkreldis.2009.11.002","article-title":"Mild cognitive impairment in Parkinson\u2019s disease: Subtypes and motor characteristics","volume":"16","author":"Sollinger","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"33929","DOI":"10.1038\/srep33929","article-title":"Prevalence and subtypes of mild cognitive impairment in Parkinson\u2019s disease","volume":"6","author":"Lawrence","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fneur.2020.00180","article-title":"Progressive Supranuclear Palsy\u2014Parkinsonism Predominant (PSP-P): A clinical challenge at the boundaries of PSP and Parkinson\u2019s Disease (PD)","volume":"11","author":"Alster","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1007\/s10072-021-05601-8","article-title":"\u201cParkinson\u2019s disease\u201d on the way to progressive supranuclear palsy: A review on PSP-parkinsonism","volume":"42","author":"Borsek","year":"2021","journal-title":"Neurol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2967\/jnumed.111.089946","article-title":"Cerebral glucose metabolic features of Parkinson disease and incident dementia: Longitudinal study","volume":"52","author":"Bohnen","year":"2011","journal-title":"J. Nucl. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/mds.27002","article-title":"Mild cognitive impairment as risk factor for Parkinson\u2019s disease dementia","volume":"32","author":"Hoogland","year":"2017","journal-title":"Mov. Disord."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/6\/741\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:24:45Z","timestamp":1760138685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/6\/741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,5]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["brainsci12060741"],"URL":"https:\/\/doi.org\/10.3390\/brainsci12060741","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,5]]}}}