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Recent work includes noninvasive techniques to demonstrate relationships between blood\u2013brain barrier (BBB) activity and the glymphatic system in the human central nervous system. One potential technique is the use of music\/sound to enhance BBB permeability regarding the movement of small molecules in and out of the brain. However, there is minimal knowledge regarding the methodical investigation(s) of the uses of music\/sound on BBB permeability and glymphatic clearance and the outcomes of these investigation(s). This review contains evidence discussing relationships between music\/sound, BBB permeability, and meningeal lymphatic clearance. An overview of the anatomy and physiology of the system is presented. We discuss the uses of music\/sound to modulate brain and body functions, highlighting music\u2019s effects on mood and autonomic, cognitive, and neuronal function. We also propose implications for follow-up work. The results showed that music and sound interventions do, in fact, contribute to the opening of the BBB and subsequently increase the function of the meningeal lymphatic system. Evidence also suggests that music\/sound has the ability to reduce the collateral effects of brain injuries. Unfortunately, music\/sound is rarely used in the clinical setting as a medical intervention. Still, recent research shows the potential positive impacts that music\/sound could have on various organ systems.<\/jats:p>","DOI":"10.3390\/brainsci12060742","type":"journal-article","created":{"date-parts":[[2022,6,5]],"date-time":"2022-06-05T10:47:11Z","timestamp":1654426031000},"page":"742","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Sound Interventions on the Permeability of the Blood\u2013Brain Barrier and Meningeal Lymphatic Clearance"],"prefix":"10.3390","volume":"12","author":[{"given":"Sean","family":"Sachdeva","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Persaud","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milani","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyton","family":"Popard","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8900-4961","authenticated-orcid":false,"given":"Aaron","family":"Colverson","sequence":"additional","affiliation":[{"name":"Musicology\/Ethnomusicology Program, School of Music, College of the Arts, University of Florida, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3771-5109","authenticated-orcid":false,"given":"Sylvain","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, FL 32610, USA"},{"name":"Departments of Pharmaceutics, Psychology, and Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neuron.2018.09.022","article-title":"The Meningeal Lymphatic System: A New Player in Neurophysiology","volume":"100","author":"Fu","year":"2018","journal-title":"Neuron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1159\/000142849","article-title":"New contributions to the anatomical connections of the brain and the lymphatic system","volume":"64","author":"Kozma","year":"1966","journal-title":"Cells Tissues Organs"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic System: A Beginner\u2019s Guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. 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