{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:41:00Z","timestamp":1782819660753,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China Grants","award":["81271493"],"award-info":[{"award-number":["81271493"]}]},{"name":"National Natural Science Foundation of China Grants","award":["7122082"],"award-info":[{"award-number":["7122082"]}]},{"name":"Beijing Natural Science Foundation Grant","award":["81271493"],"award-info":[{"award-number":["81271493"]}]},{"name":"Beijing Natural Science Foundation Grant","award":["7122082"],"award-info":[{"award-number":["7122082"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Although cognitive behavioral therapy (CBT) is effective for patients with obsessive-compulsive disorder (OCD), 40% of OCD patients show a poor response to CBT. This study aimed to identify the cortical structural factors that predict CBT outcomes in OCD patients. A total of 56 patients with OCD received baseline structural MRI (sMRI) scanning and 14 individual CBT sessions. The linear support vector regression (SVR) models were used to identify the predictive performance of sMRI indices, including gray matter volume, cortical thickness, sulcal depth, and gyrification value. The patients\u2019 OC symptoms decreased significantly after CBT intervention (p &lt; 0.001). We found the model with the comprehensive variables exhibited better performance than the models with single structural indices (MAE = 0.14, MSE = 0.03, R2 = 0.36), showing a significant correlation between the true value and the predicted value (r = 0.63, p &lt; 0.001). The results indicated that a model integrating four cortical structural features can accurately predict the effectiveness of CBT for OCD. Future models incorporating other brain indicators, including brain functional indicators, EEG indicators, neurotransmitters, etc., which might be more accurate for predicting the effectiveness of CBT for OCD, are needed.<\/jats:p>","DOI":"10.3390\/brainsci12070921","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:12:40Z","timestamp":1657757560000},"page":"921","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comprehensive Cortical Structural Features Predict the Efficacy of Cognitive Behavioral Therapy in Obsessive-Compulsive Disorder"],"prefix":"10.3390","volume":"12","author":[{"given":"Xiang-Yun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China"},{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-1144","authenticated-orcid":false,"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China"},{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China"},{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China"},{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Chong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China"},{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China"},{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China"},{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Behavioral Science & Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan-Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China"},{"name":"The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing 100088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/bmj.333.7565.424","article-title":"Obsessive-compulsive disorder","volume":"333","author":"Heyman","year":"2006","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41572-019-0102-3","article-title":"Obsessive-compulsive disorder","volume":"5","author":"Stein","year":"2019","journal-title":"Nat. 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