{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:12:00Z","timestamp":1790082720473,"version":"4.0.1"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["62076169"],"award-info":[{"award-number":["62076169"]}]},{"name":"National Natural Science Foundation of China","award":["QML20200304"],"award-info":[{"award-number":["QML20200304"]}]},{"name":"National Natural Science Foundation of China","award":["DFL 20200303"],"award-info":[{"award-number":["DFL 20200303"]}]},{"name":"Beijing Hospitals Authority Youth Program","award":["62076169"],"award-info":[{"award-number":["62076169"]}]},{"name":"Beijing Hospitals Authority Youth Program","award":["QML20200304"],"award-info":[{"award-number":["QML20200304"]}]},{"name":"Beijing Hospitals Authority Youth Program","award":["DFL 20200303"],"award-info":[{"award-number":["DFL 20200303"]}]},{"name":"Beijing Municipal Administration of Hospitals","award":["62076169"],"award-info":[{"award-number":["62076169"]}]},{"name":"Beijing Municipal Administration of Hospitals","award":["QML20200304"],"award-info":[{"award-number":["QML20200304"]}]},{"name":"Beijing Municipal Administration of Hospitals","award":["DFL 20200303"],"award-info":[{"award-number":["DFL 20200303"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The present study aimed to investigate the association between the functional connectivity (FC) of the olfactory cortex and olfactory performance in Parkinson\u2019s disease (PD). Eighty-two early PD patients and twenty-one healthy controls underwent structural and resting-state functional MRI scans, as well as neuropsychological assessments from the Parkinson\u2019s Progression Markers Initiative database. A whole brain voxel-wise regression analysis was conducted to evaluate the relationship between the FC of the entorhinal cortex (EC-FC) and olfactory performance. Then, a one-way ANCOVA, based on the regions of interest, was performed with SPSS to investigate the group differences and correlation analysis that were used to analyze the relationships between the FC and neuropsychological assessments. In addition, regression models were used to evaluate the risk factors for the decreased olfactory function. A significantly negative correlation was observed between the olfactory performance and the left EC-FC in the right dorsal cingulate gyrus (dCC) in patients. The PD patients with anosmia exhibited significantly higher FC values than the PD patients with normal olfaction or the PD patients with mild to moderate microsomia. Except for the olfactory performance, no significant correlation was detected between the neuropsychological assessments and the FC values. A linear regression analysis revealed that the increased FC and Geriatric Depression Scale are independently associated with lower the University of Pennsylvania Smell Identification Test scores. The current findings enhanced the understanding of olfactory dysfunction-related pathophysiological mechanisms in early PD and suggested that the left EC-FC in the right dCC may be a potential neuroimaging biomarker for olfactory performance.<\/jats:p>","DOI":"10.3390\/brainsci12080963","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T12:53:45Z","timestamp":1658494425000},"page":"963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between Functional Connectivity of Entorhinal Cortex and Olfactory Performance in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"Wentao","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Geriatric Hospital, Beijing 100095, China"},{"name":"Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Lab, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-2884","authenticated-orcid":false,"given":"Xiuqin","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"},{"name":"Key Lab of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"},{"name":"Key Lab of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nrneurol.2016.152","article-title":"Advances in markers of prodromal Parkinson disease","volume":"12","author":"Postuma","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/1531-8257(200005)15:3<474::AID-MDS1008>3.0.CO;2-X","article-title":"Early detection of probable idiopathic Parkinson\u2019s disease: II. A prospective application of a diagnostic test battery","volume":"15","author":"Montgomery","year":"2000","journal-title":"Mov. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1002\/mds.28127","article-title":"Application of a Simple Parkinson\u2019s Disease Risk Score in a Longitudinal Population-Based Cohort","volume":"35","author":"Marini","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/mds.22534","article-title":"Hyposmia and executive dysfunction as predictors of future Parkinson\u2019s disease: A prospective study","volume":"24","author":"Ponsen","year":"2009","journal-title":"Mov. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1212\/WNL.0000000000001265","article-title":"Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD","volume":"84","author":"Mahlknecht","year":"2015","journal-title":"Neurology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.neuroscience.2009.04.050","article-title":"Olfactory-induced brain activity in Parkinson\u2019s disease relates to the expression of event-related potentials: A functional magnetic resonance imaging study","volume":"162","author":"Wattendorf","year":"2009","journal-title":"Neuroscience"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fnint.2010.00125","article-title":"Olfactory FMRI in patients with Parkinson\u2019s disease","volume":"4","author":"Hummel","year":"2010","journal-title":"Front. Integr. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/jnnp.2006.113860","article-title":"Functional imaging of the cerebral olfactory system in patients with Parkinson\u2019s disease","volume":"79","author":"Westermann","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1093\/cercor\/bhq202","article-title":"Altered activation patterns within the olfactory network in Parkinson\u2019s disease","volume":"21","author":"Moessnang","year":"2011","journal-title":"Cereb. Cortex"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"101946","DOI":"10.1016\/j.nicl.2019.101946","article-title":"A study of neural activity and functional connectivity within the olfactory brain network in Parkinson\u2019s disease","volume":"23","author":"Georgiopoulos","year":"2019","journal-title":"Neuroimage Clin."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar MRI","volume":"34","author":"Biswal","year":"1995","journal-title":"Magn. Reson. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2003.12.030","article-title":"Regional homogeneity approach to fMRI data analysis","volume":"22","author":"Zang","year":"2004","journal-title":"Neuroimage"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.brainresrev.2005.08.004","article-title":"On the scent of human olfactory orbitofrontal cortex: Meta-analysis and comparison to non-human primates","volume":"50","author":"Gottfried","year":"2005","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nn.4517","article-title":"A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning","volume":"20","author":"Li","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.pneurobio.2011.09.005","article-title":"The Parkinson Progression Marker Initiative (PPMI)","volume":"95","author":"Marek","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0031-9384(84)90269-5","article-title":"Development of the University of Pennsylvania Smell Identification Test: A standardized microencapsulated test of olfactory function","volume":"32","author":"Doty","year":"1984","journal-title":"Physiol. Behav."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1212\/WNL.0000000000000960","article-title":"Imaging prodromal Parkinson disease: The Parkinson Associated Risk Syndrome Study","volume":"83","author":"Jennings","year":"2014","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.parkreldis.2016.02.013","article-title":"Olfactory impairment predicts cognitive decline in early Parkinson\u2019s disease","volume":"25","author":"Fullard","year":"2016","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","year":"2012","journal-title":"Brain Connect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","article-title":"A component based noise correction method (CompCor) for BOLD and perfusion based fMRI","volume":"37","author":"Behzadi","year":"2007","journal-title":"Neuroimage"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.neuroimage.2004.12.034","article-title":"A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data","volume":"25","author":"Eickhoff","year":"2005","journal-title":"Neuroimage"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/nimg.1997.0315","article-title":"Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations","volume":"7","author":"Lowe","year":"1998","journal-title":"Neuroimage"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4097\/kja.19087","article-title":"Multicollinearity and misleading statistical results","volume":"72","author":"Kim","year":"2019","journal-title":"Korean J. Anesthesiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1002\/mds.21065","article-title":"Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson\u2019s disease reconsidered","volume":"21","author":"Braak","year":"2006","journal-title":"Mov. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neulet.2009.02.006","article-title":"Regional differences in the severity of Lewy body pathology across the olfactory cortex","volume":"453","author":"Holton","year":"2009","journal-title":"Neurosci. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/B978-0-444-64196-0.00013-3","article-title":"Cingulate cortex in Parkinson\u2019s disease","volume":"166","author":"Vogt","year":"2019","journal-title":"Handb. Clin. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0165-0173(96)00011-2","article-title":"Circuitry and functional aspects of the insular lobe in primates including humans","volume":"22","author":"Augustine","year":"1996","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1006\/nimg.2000.0713","article-title":"Activation and habituation in olfaction\u2014An fMRI study","volume":"13","author":"Poellinger","year":"2001","journal-title":"Neuroimage"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s11682-017-9781-0","article-title":"Exploring white matter microstructure and olfaction dysfunction in early parkinson disease: Diffusion MRI reveals new insight","volume":"13","author":"Sobhani","year":"2019","journal-title":"Brain Imaging Behav."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.parkreldis.2015.04.006","article-title":"Alterations in the limbic\/paralimbic cortices of Parkinson\u2019s disease patients with hyposmia under resting-state functional MRI by regional homogeneity and functional connectivity analysis","volume":"21","author":"Su","year":"2015","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbr.2006.02.013","article-title":"The clinical significance of electrophysiological measures of olfactory function","volume":"170","author":"Hummel","year":"2006","journal-title":"Behav. Brain Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/brain\/awr321","article-title":"Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson\u2019s disease: A 3 year longitudinal study","volume":"135","author":"Baba","year":"2012","journal-title":"Brain"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/mds.23234","article-title":"Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson\u2019s disease","volume":"25","author":"Stephenson","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/mds.23792","article-title":"Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson\u2019s disease","volume":"26","author":"Morley","year":"2011","journal-title":"Mov. Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ana.21291","article-title":"Association of olfactory dysfunction with risk for future Parkinson\u2019s disease","volume":"63","author":"Ross","year":"2008","journal-title":"Ann. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1007\/s00415-018-8913-9","article-title":"Correlation among olfactory function, motors\u2019 symptoms, cognitive impairment, apathy, and fatigue in patients with Parkinson\u2019s disease","volume":"265","author":"Masala","year":"2018","journal-title":"J. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41582-021-00486-9","article-title":"Prodromal Parkinson disease subtypes\u2014Key to understanding heterogeneity","volume":"17","author":"Berg","year":"2021","journal-title":"Nat. Rev. Neurol."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/8\/963\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:54:49Z","timestamp":1760140489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/8\/963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["brainsci12080963"],"URL":"https:\/\/doi.org\/10.3390\/brainsci12080963","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]}}}