{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:33:52Z","timestamp":1792805632764,"version":"4.5.0"},"reference-count":38,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81901199"],"award-info":[{"award-number":["81901199"]}]},{"name":"National Natural Science Foundation of China","award":["81601022"],"award-info":[{"award-number":["81601022"]}]},{"name":"National Natural Science Foundation of China","award":["2021HXBH081"],"award-info":[{"award-number":["2021HXBH081"]}]},{"name":"1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYGD18009), Post-Doctor Research Project, West China Hospital, Sichuan University","award":["81901199"],"award-info":[{"award-number":["81901199"]}]},{"name":"1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYGD18009), Post-Doctor Research Project, West China Hospital, Sichuan University","award":["81601022"],"award-info":[{"award-number":["81601022"]}]},{"name":"1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYGD18009), Post-Doctor Research Project, West China Hospital, Sichuan University","award":["2021HXBH081"],"award-info":[{"award-number":["2021HXBH081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: We aimed to assess the retinal structural and choroidal changes in carotid artery stenosis (CAS) patients and their association with cerebral hemodynamic changes. Asymptomatic and symptomatic patients with unilateral CAS were enrolled in our study. Material and methods: Swept-source optical coherence tomography (SS-OCT) was used to image the retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), while SS-OCT angiography (SS-OCTA) was used to image and measure the choroidal vascular volume (CVV) and choroidal vascular index (CVI). Computed Tomography Perfusion (CTP) was used to assess the cerebral perfusion parameters; relative perfusion (r) was calculated as the ratio of the value on the contralateral side to that on the ipsilateral side. Results: Compared with contralateral eyes, ipsilateral eyes showed significantly thinner RNFL (p &lt; 0.001), GCIPL (p = 0.013) and CVV (p = 0.001). Relative cerebral blood volume (rCBV) showed a significant correlation with RNFL (p &lt; 0.001), GCIPL (p &lt; 0.001) and CVI (p = 0.027), while the relative permeability surface (rPS) correlated with RNFL (p &lt; 0.001) and GCIPL (p &lt; 0.001). Conclusions: Our report suggests that retinal and choroidal changes have the potential to detect hemodynamic changes in CAS patients and could predict the risk of stroke.<\/jats:p>","DOI":"10.3390\/brainsci12080979","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T21:20:59Z","timestamp":1658784059000},"page":"979","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Retinal Thickness Correlates with Cerebral Hemodynamic Changes in Patients with Carotid Artery Stenosis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-4694","authenticated-orcid":false,"given":"William Robert","family":"Kwapong","sequence":"first","affiliation":[{"name":"Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincheng","family":"Wan","sequence":"additional","affiliation":[{"name":"Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendan","family":"Tao","sequence":"additional","affiliation":[{"name":"Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-5486","authenticated-orcid":false,"given":"Chen","family":"Ye","sequence":"additional","affiliation":[{"name":"Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/j.jvs.2020.10.063","article-title":"Asymptomatic carotid artery stenosis is associated with cerebral hypoperfusion","volume":"73","author":"Khan","year":"2021","journal-title":"J. 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