{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:05:24Z","timestamp":1778943924597,"version":"3.51.4"},"reference-count":136,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81971247"],"award-info":[{"award-number":["81971247"]}]},{"name":"National Natural Science Foundation of China","award":["2020C03064"],"award-info":[{"award-number":["2020C03064"]}]},{"name":"National Natural Science Foundation of China","award":["2022S075"],"award-info":[{"award-number":["2022S075"]}]},{"name":"National Natural Science Foundation of China","award":["18ZDA215"],"award-info":[{"award-number":["18ZDA215"]}]},{"name":"Zhejiang Provincial Key R &amp; D Plan 2019","award":["81971247"],"award-info":[{"award-number":["81971247"]}]},{"name":"Zhejiang Provincial Key R &amp; D Plan 2019","award":["2020C03064"],"award-info":[{"award-number":["2020C03064"]}]},{"name":"Zhejiang Provincial Key R &amp; D Plan 2019","award":["2022S075"],"award-info":[{"award-number":["2022S075"]}]},{"name":"Zhejiang Provincial Key R &amp; D Plan 2019","award":["18ZDA215"],"award-info":[{"award-number":["18ZDA215"]}]},{"name":"Science and Technology Plan of Ningbo","award":["81971247"],"award-info":[{"award-number":["81971247"]}]},{"name":"Science and Technology Plan of Ningbo","award":["2020C03064"],"award-info":[{"award-number":["2020C03064"]}]},{"name":"Science and Technology Plan of Ningbo","award":["2022S075"],"award-info":[{"award-number":["2022S075"]}]},{"name":"Science and Technology Plan of Ningbo","award":["18ZDA215"],"award-info":[{"award-number":["18ZDA215"]}]},{"name":"\u201cOne-health\u201d Plan of Ningbo University, National Social Science Foundation Key Programs","award":["81971247"],"award-info":[{"award-number":["81971247"]}]},{"name":"\u201cOne-health\u201d Plan of Ningbo University, National Social Science Foundation Key Programs","award":["2020C03064"],"award-info":[{"award-number":["2020C03064"]}]},{"name":"\u201cOne-health\u201d Plan of Ningbo University, National Social Science Foundation Key Programs","award":["2022S075"],"award-info":[{"award-number":["2022S075"]}]},{"name":"\u201cOne-health\u201d Plan of Ningbo University, National Social Science Foundation Key Programs","award":["18ZDA215"],"award-info":[{"award-number":["18ZDA215"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The NLRP inflammasome is a multi-protein complex which mainly consists of the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain. Its activation is linked to microglial-mediated neuroinflammation and partial neuronal degeneration. Many neuropsychiatric illnesses have increased inflammatory responses as both a primary cause and a defining feature. The NLRP inflammasome inhibition delays the progression and alleviates the deteriorating effects of neuroinflammation on several neuropsychiatric disorders. Evidence on the central effects of the NLRP inflammasome potentially provides the scientific base of a promising drug target for the treatment of neuropsychiatric disorders. This review elucidates the classification, composition, and functions of the NLRP inflammasomes. It also explores the underlying mechanisms of NLRP inflammasome activation and its divergent role in neuropsychiatric disorders, including Alzheimer\u2019s disease, Huntington\u2019s disease, Parkinson\u2019s disease, depression, drug use disorders, and anxiety. Furthermore, we explore the treatment potential of the NLRP inflammasome inhibitors against these disorders.<\/jats:p>","DOI":"10.3390\/brainsci12081057","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:42:56Z","timestamp":1660124576000},"page":"1057","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Significance of NLRP Inflammasome in Neuropsychiatric Disorders"],"prefix":"10.3390","volume":"12","author":[{"given":"Yao","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Public Health, School of Medicine, Ningbo University, Ningbo 315021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liyin","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, Ningbo University, Ningbo 315021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Teacher Education, Ningbo University, Ningbo 315021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Teacher Education, Ningbo University, Ningbo 315021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuer","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Teacher Education, Ningbo University, Ningbo 315021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runyue","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, Ningbo University, Ningbo 315021, China"},{"name":"Ningbo Yinzhou District Center for Disease Control and Prevention, Ningbo 315199, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zizhen","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Physiological Pharmacology, School of Medicine, Ningbo University, Ningbo 315021, China"},{"name":"Department of Pharmacology, Affiliated Hospital of Medical School, Ningbo University, Ningbo 315020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4593-8989","authenticated-orcid":false,"given":"Yunpeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, Ningbo University, Ningbo 315021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longhui","family":"Li","sequence":"additional","affiliation":[{"name":"Ningbo Kangning Hospital, Ningbo 315201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiological Pharmacology, School of Medicine, Ningbo University, Ningbo 315021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/imm.12233","article-title":"Inflammation in neurodegenerative diseases\u2014An update","volume":"142","author":"Amor","year":"2014","journal-title":"Immunology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/imm.12922","article-title":"Inflammation in CNS neurodegenerative diseases","volume":"154","author":"Stephenson","year":"2018","journal-title":"Immunology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41586-021-03316-6","article-title":"Pattern-recognition receptors are required for NLR-mediated plant immunity","volume":"592","author":"Yuan","year":"2021","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 inflammasome in acute myocardial infarction","volume":"15","author":"Toldo","year":"2018","journal-title":"Nat. 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