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While increased oxidative stress (OS) has been associated with sleep disorders, less is known about its relationship with sleep quality. Similarly, little is known of how this relationship might change with exercise, which can improve sleep quality. Factors of sleep quality, such as sleep duration and disturbances, are also important as they predict cardiovascular diseases better than a global score alone. This study investigated whether OS was associated with self-rated sleep quality and its factors before and after completing a 24-week exercise intervention. (2) Methods: CAD patients undergoing an exercise program were recruited. OS was measured at baseline by the concentrations of early- (lipid hydroperoxides, LPH) and late-stage (8-isoprostane, 8-ISO) lipid peroxidation products and their ratio. Sleep quality was measured by the self-reported Pittsburgh Sleep Quality Index (PSQI) instrument at baseline and termination. Three sleep factors\u2014perceived sleep quality, sleep efficiency, and daily disturbances\u2014were derived from the PSQI. (3) Results: Among CAD patients (n = 113, 85.0% male, age = 63.7 \u00b1 6.4 years, global PSQI = 5.8 \u00b1 4.0), those with poor sleep (PSQI \u2265 5) had higher baseline 8-ISO levels (F(1, 111) = 6.212, p = 0.014, \u03b7p2 = 0.053) compared to those with normal sleep. Concentrations of LPH (F(1, 105) = 0.569, p = 0.453, \u03b7p2 = 0.005) and 8-ISO\/LPH ratios (F(1, 105) = 2.173, p = 0.143, \u03b7p2 = 0.020) did not differ between those with poor sleep and normal sleep. Among factors, perceived sleep quality was associated with 8-ISO and 8-ISO\/LPH, and daily disturbances were associated with 8-ISO. (4) Conclusions: A marker of late-stage lipid peroxidation is elevated in CAD patients with poor sleep and associated with daily disturbances, but not with other factors or with sleep quality and its factors after exercise intervention.<\/jats:p>","DOI":"10.3390\/brainsci12081070","type":"journal-article","created":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T21:09:06Z","timestamp":1660511346000},"page":"1070","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Relationship between Oxidative Stress and Subjective Sleep Quality in People with Coronary Artery Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-5590","authenticated-orcid":false,"given":"Vivian","family":"Feng","sequence":"first","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, 1 King\u2019s College Cir, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar","family":"Tumati","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoding","family":"Wang","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritleen K.","family":"Bawa","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, 1 King\u2019s College Cir, Toronto, ON M5S 1A8, Canada"},{"name":"Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada"},{"name":"Evaluative Clinical Sciences, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, Canada"},{"name":"Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, 1 King\u2019s College Cir, Toronto, ON M5S 1A8, Canada"},{"name":"Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada"},{"name":"Evaluative Clinical Sciences, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-400X","authenticated-orcid":false,"given":"Susan","family":"Marzolini","sequence":"additional","affiliation":[{"name":"KITE Toronto Rehabilitation Institute, University Health Network, East York, ON M5G 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Oh","sequence":"additional","affiliation":[{"name":"KITE Toronto Rehabilitation Institute, University Health Network, East York, ON M5G 2A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-7273","authenticated-orcid":false,"given":"Ana","family":"Andreazza","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, 1 King\u2019s College Cir, Toronto, ON M5S 1A8, Canada"},{"name":"Geriatric Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada"},{"name":"Centre for Addictions and Mental Health, 1000 Queen Street West, Toronto, ON M6J 1H4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7024-6637","authenticated-orcid":false,"given":"Krista L.","family":"Lanct\u00f4t","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Research Group, Sunnybrook Research Institute, 2075 Bayview Avenue, Room FG21, Toronto, ON M4N 3M5, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Toronto, 1 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