{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:57:11Z","timestamp":1792789031991,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sastry Foundation Imaging Initiative"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Purpose: To examine the optical coherence tomography (OCT) features of the retina in patients with chronic relapsing inflammatory optic neuropathy (CRION) and compare them with those of neuromyelitis optica spectrum disorder (NMOSD), relapsing-remitting multiple sclerosis (RRMS) with and without optic neuritis (ON), and healthy controls (HC). Methods: In this retrospective cross-sectional study, we used spectral domain OCT to evaluate the retinal structure of 14 participants with CRION, 22 with NMOSD, 40 with RRMS with unilateral ON, and 20 HC. The peripapillary retinal nerve fiber layer (pRNFL), total macular volume (TMV), and papillomacular bundle (PMB) were measured, and intra-retinal segmentation was performed to obtain the retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL) and outer nuclear (ONL) layer volumes. Results: The global pRNFL [39.33(\u00b11.8) \u00b5m] and all its quadrants are significantly thinner in CRION compared with all other groups (p &lt; 0.05). CRION patients have decreased volumes of TMV, RNFL, GCL, and IPL compared with all other groups (p &lt; 0.05). Conclusion: Severe thinning in pRNFL and thinning in intra-retinal segments of IPL, GCL, RNFL, and TMV could be helpful in differentiating CRION from NMOSD and RRMS.<\/jats:p>","DOI":"10.3390\/brainsci12091140","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T21:22:56Z","timestamp":1661721776000},"page":"1140","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Optical Coherence Tomography in Chronic Relapsing Inflammatory Optic Neuropathy, Neuromyelitis Optica and Multiple Sclerosis: A Comparative Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Maziar","family":"Eslami","sequence":"first","affiliation":[{"name":"Department of Neurology, University Health Center, Detroit, MI 48201, USA"},{"name":"School of Medicine, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-9409","authenticated-orcid":false,"given":"Samuel","family":"Lichtman-Mikol","sequence":"additional","affiliation":[{"name":"School of Medicine, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Razmjou","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Health Center, Detroit, MI 48201, USA"},{"name":"School of Medicine, Wayne State University, Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9382-1008","authenticated-orcid":false,"given":"Evanthia","family":"Bernitsas","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Health Center, Detroit, MI 48201, USA"},{"name":"School of Medicine, Wayne State University, Detroit, MI 48201, USA"},{"name":"Wayne State Neuroimaging Center, Sastry Foundation Neuro-Imaging Initiative, University Health Center, 8D, 4201 St. Antoine St., Detroit, MI 48201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/brain\/awg045","article-title":"Chronic relapsing inflammatory optic neuropathy (CRION)","volume":"126","author":"Kidd","year":"2003","journal-title":"Brain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00415-013-6957-4","article-title":"Chronic relapsing inflammatory optic neuropathy: A systematic review of 122 cases reported","volume":"261","author":"Petzold","year":"2014","journal-title":"J. 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