{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:56:55Z","timestamp":1788541015727,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82171282"],"award-info":[{"award-number":["82171282"]}]},{"name":"National Natural Science Foundation of China","award":["2020101"],"award-info":[{"award-number":["2020101"]}]},{"name":"National Natural Science Foundation of China","award":["M2020064"],"award-info":[{"award-number":["M2020064"]}]},{"name":"National Natural Science Foundation of China","award":["Qngg2021003"],"award-info":[{"award-number":["Qngg2021003"]}]},{"name":"Suzhou Mingsheng Science Technology Project","award":["82171282"],"award-info":[{"award-number":["82171282"]}]},{"name":"Suzhou Mingsheng Science Technology Project","award":["2020101"],"award-info":[{"award-number":["2020101"]}]},{"name":"Suzhou Mingsheng Science Technology Project","award":["M2020064"],"award-info":[{"award-number":["M2020064"]}]},{"name":"Suzhou Mingsheng Science Technology Project","award":["Qngg2021003"],"award-info":[{"award-number":["Qngg2021003"]}]},{"name":"Scientific Research Project of Jiangsu Provincial Health and Wellness Committee","award":["82171282"],"award-info":[{"award-number":["82171282"]}]},{"name":"Scientific Research Project of Jiangsu Provincial Health and Wellness Committee","award":["2020101"],"award-info":[{"award-number":["2020101"]}]},{"name":"Scientific Research Project of Jiangsu Provincial Health and Wellness Committee","award":["M2020064"],"award-info":[{"award-number":["M2020064"]}]},{"name":"Scientific Research Project of Jiangsu Provincial Health and Wellness Committee","award":["Qngg2021003"],"award-info":[{"award-number":["Qngg2021003"]}]},{"name":"Health Youth Backbone Project of Suzhou City","award":["82171282"],"award-info":[{"award-number":["82171282"]}]},{"name":"Health Youth Backbone Project of Suzhou City","award":["2020101"],"award-info":[{"award-number":["2020101"]}]},{"name":"Health Youth Backbone Project of Suzhou City","award":["M2020064"],"award-info":[{"award-number":["M2020064"]}]},{"name":"Health Youth Backbone Project of Suzhou City","award":["Qngg2021003"],"award-info":[{"award-number":["Qngg2021003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>After the onset of ischemic stroke, ischemia\u2013hypoxic cascades cause irreversible neuronal death. Neurons are the fundamental structures of the central nervous system, and mature neurons do not renew or multiply after death. Functional and structural recovery from neurological deficits caused by ischemic attack is a huge task. Hence, there remains a need to replace the lost neurons relying on endogenous neurogenesis or exogenous stem cell-based neuronal differentiation. However, the stem cell source difficulty and the risk of immune rejection of the allogeneic stem cells might hinder the wide clinical application of the above therapy. With the advancement of transdifferentiation induction technology, it has been demonstrated that astrocytes can be converted to neurons through ectopic expression or the knockdown of specific components. The progress and problems of astrocyte transdifferentiation will be discussed in this article.<\/jats:p>","DOI":"10.3390\/brainsci12091175","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T03:55:38Z","timestamp":1662004538000},"page":"1175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Astrocyte-Derived Neuronal Transdifferentiation as a Therapy for Ischemic Stroke: Advances and Challenges"],"prefix":"10.3390","volume":"12","author":[{"given":"Siqi","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of SooChow University, Suzhou 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of SooChow University, Suzhou 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3496-3281","authenticated-orcid":false,"given":"Xiuying","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of SooChow University, Suzhou 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5174-6887","authenticated-orcid":false,"given":"Juehua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of SooChow University, Suzhou 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/jcbfm.2014.130","article-title":"Neurogenesis and inflammation after ischemic stroke: What is known and where we go from here","volume":"34","author":"Tobin","year":"2014","journal-title":"J. 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