{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:29:29Z","timestamp":1760956169874,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19) could be a risk factor for acute ischemic stroke (AIS) due to the altered coagulation process and hyperinflammation. This study examined the risk factors, clinical profile, and hospital outcomes of COVID-19 hospitalizations with AIS. This study was a retrospective analysis of data from California State Inpatient Database (SID) during 2019 and 2020. COVID-19 hospitalizations with age \u2265 18 years during 2020 and a historical cohort without COVID-19 from 2019 were included in the analysis. The primary outcomes studied were in-hospital mortality and discharge to destinations other than home. There were 91,420 COVID-19 hospitalizations, of which, 1027 (1.1%) had AIS. The historical control cohort included 58,083 AIS hospitalizations without COVID-19. Conditional logistic regression analysis showed that the odds of in-hospital mortality, discharge to destinations other than home, DVT, pulmonary embolism, septic shock, and mechanical ventilation were significantly higher among COVID-19 hospitalizations with AIS, compared to those without AIS. The odds of in-hospital mortality, DVT, pulmonary embolism, septic shock, mechanical ventilation, and respiratory failure were significantly higher among COVID-19 hospitalizations with AIS, compared to AIS hospitalizations without COVID-19. Although the prevalence of AIS was low among COVID-19 hospitalizations, it was associated with higher mortality and greater rates of discharges to destinations other than home.<\/jats:p>","DOI":"10.3390\/brainsci12091177","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T21:27:17Z","timestamp":1662067637000},"page":"1177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hospital Outcomes among COVID-19 Hospitalizations with Acute Ischemic Stroke: Cross-Sectional Study Results from California State Inpatient Database"],"prefix":"10.3390","volume":"12","author":[{"given":"Muni","family":"Rubens","sequence":"first","affiliation":[{"name":"Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2485-5017","authenticated-orcid":false,"given":"Anshul","family":"Saxena","sequence":"additional","affiliation":[{"name":"Center for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USA"},{"name":"Department of Neurology, Florida International University, Miami, FL 33199, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkataraghavan","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Center for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Ashfaq","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Center for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5069-6638","authenticated-orcid":false,"given":"Peter","family":"McGranaghan","sequence":"additional","affiliation":[{"name":"Miami Cancer Institute, Baptist Health South Florida, Miami, FL 33176, USA"},{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3831-5433","authenticated-orcid":false,"given":"Emir","family":"Veledar","sequence":"additional","affiliation":[{"name":"Center for Advanced Analytics, Baptist Health South Florida, Miami, FL 33176, USA"},{"name":"Department of Neurology, Florida International University, Miami, FL 33199, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Neurology, Florida International University, Miami, FL 33199, USA"},{"name":"Miami Neuroscience Institute, Baptist Health South Florida, Miami, FL 33176, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"De Los Rios La Rosa","sequence":"additional","affiliation":[{"name":"Miami Neuroscience Institute, Baptist Health South Florida, Miami, FL 33176, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"ref_1","unstructured":"(2020, November 15). 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