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Five sessions of iTBS were carried over the left dorsolateral prefrontal cortex (DLPFC) or the vertex as a sham control, with each session in one day. Orientation free-recall tasks were conducted before the iTBS stimulation, after the first and fifth sessions of stimulation. Results showed that when compared with the sham group, a single session of iTBS over the left DLPFC improved participants\u2019 working memory performance. Specifically, iTBS over the left DLPFC increased the working memory capacity and such effects enlarged with multiple sessions. The present finding suggested that iTBS over DLPFC could be a promising intervention method to enhance the cognitive function of addicts with MUD.<\/jats:p>","DOI":"10.3390\/brainsci12091212","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T09:51:09Z","timestamp":1662630669000},"page":"1212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Intermittent Theta-Burst Stimulation Increases the Working Memory Capacity of Methamphetamine Addicts"],"prefix":"10.3390","volume":"12","author":[{"given":"Yurong","family":"Sun","sequence":"first","affiliation":[{"name":"School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-5123","authenticated-orcid":false,"given":"Yixuan","family":"Ku","sequence":"additional","affiliation":[{"name":"Center for Brain and Mental Well-Being, Department of Psychology, Sun Yat-sen University, Guangzhou 510275, China"},{"name":"Peng Cheng Laboratory, Shenzhen 518066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1037\/amp0000059","article-title":"Liking, Wanting, and the Incentive-Sensitization Theory of Addiction","volume":"71","author":"Berridge","year":"2016","journal-title":"Am. Psychol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrn.2017.130","article-title":"The Dopamine Motive System: Implications for Drug and Food Addiction","volume":"18","author":"Volkow","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-psych-122414-033457","article-title":"Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On","volume":"67","author":"Everitt","year":"2016","journal-title":"Annu. Rev. Psychol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamapsychiatry.2015.1","article-title":"Impaired Functional Connectivity within and between Frontostriatal Circuits and Its Association with Compulsive Drug Use and Trait Impulsivity in Cocaine Addiction","volume":"72","author":"Hu","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrn3119","article-title":"Dysfunction of the Prefrontal Cortex in Addiction: Neuroimaging Findings and Clinical Implications","volume":"12","author":"Goldstein","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1364-6613(03)00197-9","article-title":"Persistent Activity in the Prefrontal Cortex during Working Memory","volume":"7","author":"Curtis","year":"2003","journal-title":"Trends Cogn. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tics.2018.12.006","article-title":"Dopamine and Cognitive Control in Prefrontal Cortex","volume":"23","author":"Ott","year":"2019","journal-title":"Trends Cogn. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.1204978","article-title":"Effects of Working-Memory Training on Striatal Dopamine Release","volume":"333","author":"Nyberg","year":"2011","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1037\/0894-4105.18.1.152","article-title":"Impaired Decision Making Related to Working Memory Deficits in Individuals With Substance Addictions","volume":"18","author":"Bechara","year":"2004","journal-title":"Neuropsychology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1038\/sj.npp.1301626","article-title":"Extended Access to Cocaine Self-Administration Produces Long-Lasting Prefrontal Cortex-Dependent Working Memory Impairments","volume":"33","author":"George","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.neuroscience.2007.09.044","article-title":"Methamphetamine Induces Alterations on Hippocampal NMDA and AMPA Receptor Subunit Levels and Impairs Spatial Working Memory","volume":"150","author":"Silva","year":"2007","journal-title":"Neuroscience"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1037\/0893-164X.22.3.426","article-title":"Working Memory Capacity Moderates the Predictive Effects of Drug-Related Associations on Substance Use","volume":"22","author":"Grenard","year":"2008","journal-title":"Psychol. Addict. Behav."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/adb.12103","article-title":"Increased Neural Activity during High Working Memory Load Predicts Low Relapse Risk in Alcohol Dependence","volume":"19","author":"Charlet","year":"2014","journal-title":"Addict. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1177\/0956797611412392","article-title":"Getting a Grip on Drinking Behavior: Training Working Memory to Reduce Alcohol Abuse","volume":"22","author":"Houben","year":"2011","journal-title":"Psychol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.drugalcdep.2009.07.020","article-title":"Working Memory Deficits Predict Short-Term Smoking Resumption Following Brief Abstinence","volume":"106","author":"Patterson","year":"2010","journal-title":"Drug Alcohol Depend."},{"key":"ref_16","first-page":"1465","article-title":"Transcranial Magnetic Stimulation (TMS) for Schizophrenia","volume":"8","author":"Dougall","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.clinph.2019.11.002","article-title":"Evidence-Based Guidelines on the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation (RTMS): An Update (2014\u20132018)","volume":"131","author":"Lefaucheur","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.brs.2016.03.010","article-title":"The Clinical TMS Society Consensus Review and Treatment Recommendations for TMS Therapy for Major Depressive Disorder","volume":"9","author":"Perera","year":"2016","journal-title":"Brain Stimulat."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1212\/WNL.48.5.1398","article-title":"Depression of Motor Cortex Excitability by Low-Frequency Transcranial Magnetic Stimulation","volume":"48","author":"Chen","year":"1997","journal-title":"Neurology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1113\/jphysiol.2008.152736","article-title":"The Physiological Basis of the Effects of Intermittent Theta Burst Stimulation of the Human Motor Cortex","volume":"586","author":"Pilato","year":"2008","journal-title":"J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuron.2004.12.033","article-title":"Theta Burst Stimulation of the Human Motor Cortex","volume":"45","author":"Huang","year":"2005","journal-title":"Neuron"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrn.2017.113","article-title":"Rehabilitating the Addicted Brain with Transcranial Magnetic Stimulation","volume":"18","author":"Diana","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3389\/fnins.2019.01095","article-title":"Effects of Non-Invasive Brain Stimulation on Stimulant Craving in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-Analysis","volume":"13","author":"Ma","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/10550887.2020.1736756","article-title":"Non-Invasive Brain Stimulation Modalities for the Treatment and Prevention of Opioid Use Disorder: A Systematic Review of the Literature","volume":"38","author":"Young","year":"2020","journal-title":"J. Addict. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1111\/add.14753","article-title":"Effects of Repetitive Transcranial Magnetic Stimulation (RTMS) on Craving and Substance Consumption in Patients with Substance Dependence: A Systematic Review and Meta-Analysis","volume":"114","author":"Zhang","year":"2019","journal-title":"Addiction"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pscychresns.2007.05.002","article-title":"Acute Prefrontal RTMS Increases Striatal Dopamine to a Similar Degree as D-Amphetamine","volume":"156","author":"Pogarell","year":"2007","journal-title":"Psychiatry Res.-Neuroimaging"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cho, S.S., and Strafella, A.P. (2009). rTMS of the Left Dorsolateral Prefrontal Cortex Modulates Dopamine Release in the Ipsilateral Anterior Cingulate Cortex and Orbitofrontal Cortex. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0006725"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Ku, Y., Sun, J., Daskalakis, Z.J., and Yuan, T.-F. (2021). Intermittent Theta Burst Stimulation to the Left Dorsolateral Prefrontal Cortex Improves Working Memory of Subjects with Methamphetamine Use Disorder. Psychol. Med., 1\u201310.","DOI":"10.1017\/S003329172100430X"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nn.3655","article-title":"Changing Concepts of Working Memory","volume":"17","author":"Ma","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature06860","article-title":"Discrete Fixed-Resolution Representations in Visual Working Memory","volume":"453","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1126\/science.173.3997.652","article-title":"Neuron Activity Related to Short-Term Memory","volume":"173","author":"Fuster","year":"1971","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0896-6273(95)90304-6","article-title":"Cellular Basis of Working Memory","volume":"14","year":"1995","journal-title":"Neuron"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12264-014-1503-7","article-title":"Prefrontal Cortex and Sensory Cortices during Working Memory: Quantity and Quality","volume":"31","author":"Ku","year":"2015","journal-title":"Neurosci. Bull."},{"key":"ref_34","first-page":"727","article-title":"The Causal Role of Right Dorsolateral Prefrontal Cortex in Visual Working Memory","volume":"50","author":"Sisi","year":"2018","journal-title":"Acta Psychol. Sin."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1017\/S0140525X01003922","article-title":"The Magical Number 4 in Short-Term Memory: A Reconsideration of Mental Storage Capacity","volume":"24","author":"Cowan","year":"2001","journal-title":"Behav. Brain Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1037\/0096-3445.128.3.309","article-title":"Working Memory, Short-Term Memory, and General Fluid Intelligence: A Latent-Variable Approach","volume":"128","author":"Engle","year":"1999","journal-title":"J. Exp. Psychol. Gen."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tics.2012.01.006","article-title":"Executive Functions and Self-Regulation","volume":"16","author":"Hofmann","year":"2012","journal-title":"Trends Cogn. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/cercor\/bhn095","article-title":"Striatal Dopamine and Working Memory","volume":"19","author":"Landau","year":"2009","journal-title":"Cereb. Cortex"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1126\/science.1825731","article-title":"D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory","volume":"251","author":"Sawaguchi","year":"1991","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuroscience.2019.11.037","article-title":"Neural Correlates Underlying the Precision of Visual Working Memory","volume":"425","author":"Zhao","year":"2020","journal-title":"Neuroscience"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1093\/cercor\/bhab300","article-title":"Sensory Recruitment Revisited: Ipsilateral V1 Involved in Visual Working Memory","volume":"32","author":"Zhao","year":"2022","journal-title":"Cereb. Cortex"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nn.4174","article-title":"Decoding the Content of Visual Short-Term Memory under Distraction in Occipital and Parietal Areas","volume":"19","author":"Bettencourt","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature04262","article-title":"Dissociable Neural Mechanisms Supporting Visual Short-Term Memory for Objects","volume":"440","author":"Xu","year":"2006","journal-title":"Nature"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/9\/1212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:27:38Z","timestamp":1760142458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/9\/1212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,8]]},"references-count":43,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["brainsci12091212"],"URL":"https:\/\/doi.org\/10.3390\/brainsci12091212","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,8]]}}}