{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:32:24Z","timestamp":1760243544029,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971404","2008085MC105","KJ2020A0095","2020rcjj46"],"award-info":[{"award-number":["31971404","2008085MC105","KJ2020A0095","2020rcjj46"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["31971404","2008085MC105","KJ2020A0095","2020rcjj46"],"award-info":[{"award-number":["31971404","2008085MC105","KJ2020A0095","2020rcjj46"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anhui Provincial Natural Science Research Project of Higher Education","award":["31971404","2008085MC105","KJ2020A0095","2020rcjj46"],"award-info":[{"award-number":["31971404","2008085MC105","KJ2020A0095","2020rcjj46"]}]},{"name":"Research Foundation for Talented Scholars of Hefei Normal University","award":["31971404","2008085MC105","KJ2020A0095","2020rcjj46"],"award-info":[{"award-number":["31971404","2008085MC105","KJ2020A0095","2020rcjj46"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Animal models play a central role in all areas of biomedical research. The similarities in anatomical structure and physiological characteristics shared by non-human primates (NHPs) and humans make NHPs ideal models with which to study human disorders, such as cerebral palsy (CP). However, the methodologies for systematically evaluating NHP models of CP have rarely been assessed, despite the long history of using NHP models to understand CP. Such models should be evaluated using multidisciplinary approaches prior to being used to research the diagnosis and treatment of CP. In this study, we evaluated rhesus macaque CP models established by partial resection of the motor cortex and intrathecal injection of bilirubin. Abnormal posture, motor dysfunction, gross and fine motor behavior, and muscular tension were evaluated, and changes in the cerebral cortex and basal ganglia were observed using 9.4 T magnetic resonance imaging. The results clearly demonstrated the utility of the established evaluation methodology for assessing CP models. This model evaluation methodology may guide researchers through the model building process.<\/jats:p>","DOI":"10.3390\/brainsci12091243","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T20:50:45Z","timestamp":1663188645000},"page":"1243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Rhesus Macaque Models for Cerebral Palsy"],"prefix":"10.3390","volume":"12","author":[{"given":"Yong","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Life Sciences, Hefei Normal University, No. 1688, Lianhua Road, Hefei 230601, China"},{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, No. 350, Shushanhu Road, Hefei 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Pediatric Neurological Rehabilitation Center, the First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Hefei 230022, China"},{"name":"Department of Emergency, Tongji Hospital of Tongji University, No. 389, Xincun Road, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, No. 350, Shushanhu Road, Hefei 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyang","family":"Tong","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, No. 350, Shushanhu Road, Hefei 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyi","family":"Yang","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, No. 350, Shushanhu Road, Hefei 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"High Magnetic Field Laboratory, Chinese Academy of Sciences, No. 350, Shushanhu Road, Hefei 230031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Xu","sequence":"additional","affiliation":[{"name":"Pediatric Neurological Rehabilitation Center, the First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Hefei 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De","family":"Wu","sequence":"additional","affiliation":[{"name":"Pediatric Neurological Rehabilitation Center, the First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Hefei 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiulai","family":"Tang","sequence":"additional","affiliation":[{"name":"Pediatric Neurological Rehabilitation Center, the First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Hefei 230022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Hefei Normal University, No. 1688, Lianhua Road, Hefei 230601, China"},{"name":"International Collaborative Research Center for Huangshan Biodiversity and Tibetan Macaque Behavioral Ecology, School of Resources and Environmental Engineering, Anhui University, No. 111, Jiulong Road, Hefei 230601, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.spen.2013.06.010","article-title":"Evidence for therapeutic intervention in the prevention of cerebral palsy: Hope from animal model research","volume":"20","author":"Nguyen","year":"2013","journal-title":"Semin. 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