{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:13:05Z","timestamp":1788970385143,"version":"build-2803163510"},"reference-count":27,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81971127"],"award-info":[{"award-number":["81971127"]}]},{"name":"National Natural Science Foundation of China","award":["ZKX20013"],"award-info":[{"award-number":["ZKX20013"]}]},{"name":"Nanjing Special Fund for Health and Technology Development","award":["81971127"],"award-info":[{"award-number":["81971127"]}]},{"name":"Nanjing Special Fund for Health and Technology Development","award":["ZKX20013"],"award-info":[{"award-number":["ZKX20013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Objective: To evaluate the efficacy of liquid embolization agents for treating various hemorrhagic peripheral intracranial aneurysms. Methods: We retrospectively analyzed 38 patients who suffered from hemorrhagic peripheral intracranial aneurysms and were treated with liquid embolization agents. We used the modified Rankin scale for follow-up at 6 months postoperatively, and digital subtraction angiography follow-up was performed 6 months postoperatively. Results: Of the 38 patients (ten of simple peripheral intracranial aneurysms, six of Moyamoya disease (MMD), and 22 of arteriovenous malformation (AVM)), posterior circulation accounted for the most significant proportion (57.9%), followed by anterior circulation (21.1%) and intranidal aneurysms (21.1%). Intraoperative hemorrhage occurred in four cases, postoperative cerebral infarction occurred in four cases, two patients encountered microcatheter retention, and intraoperative thrombosis took place in the basilar artery of a patient with an arteriovenous malformation. A postoperative hemorrhage occurred in only one patient. At 6-month follow-up, 84.2% of patients had good prognosis outcomes, and 13.5% had poor outcomes. Conclusion: Liquid embolization agents are effective for hemorrhagic peripheral intracranial aneurysms; however, safety depends on the subtypes. For peripheral hemorrhagic aneurysms in MMD, the vessel architecture must be carefully evaluated before embolization.<\/jats:p>","DOI":"10.3390\/brainsci12091264","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T04:49:22Z","timestamp":1663562962000},"page":"1264","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Liquid Embolic Agent Treatment in Hemorrhagic Peripheral Intracranial Aneurysms: A Single-Center Experience"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2842-4676","authenticated-orcid":false,"given":"Zong","family":"Zhuang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"},{"name":"Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8393-9360","authenticated-orcid":false,"given":"Qi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun-Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ping","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hua","family":"Hang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Dong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Affiliated Drum Tower Hospital, School of Medicine, Nanjing University, Zhongshan Road 321, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nussbaum, L.A., Kallmes, K.M., and Nussbaum, E.S. (2019). Technical note: The use of frameless stereotactic guidance in the treatment of peripheral intracranial aneurysms. Br. J. Neurosurg., 1\u20135.","DOI":"10.1080\/02688697.2019.1668539"},{"key":"ref_2","first-page":"133","article-title":"Endovascular treatment of ruptured peripheral intracranial aneurysms","volume":"17","author":"Chen","year":"2012","journal-title":"Neurosciences"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3171\/2008.6.JNS0814","article-title":"Peripheral intracranial aneurysms: Management challenges in 60 con-secutive cases","volume":"110","author":"Nussbaum","year":"2009","journal-title":"J. Neurosurg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1136\/neurintsurg-2014-011258","article-title":"An update to the Raymond-Roy Occlusion Classification of intracranial an-eurysms treated with coil embolization","volume":"7","author":"Mascitelli","year":"2015","journal-title":"J. Neurointerv. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"570198","DOI":"10.3389\/fneur.2020.570198","article-title":"Single-Stage Combined Embolization and Resection for Spetzler-Martin Grade III\/IV\/V Arteriovenous Malformations: A Single-Center Experience and Literature Review","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/STROKEAHA.117.017866","article-title":"Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials","volume":"48","author":"Broderick","year":"2017","journal-title":"Stroke"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.wneu.2019.04.145","article-title":"Endovascular Treatment for Peripheral Superior Cerebellar Artery Aneurysms: Current State and Future Considerations","volume":"127","author":"Hou","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/2152-7806.82247","article-title":"Ruptured peripheral aneurysms in a collateral pathway associated with stenosis of a major cerebral artery: Report of two cases","volume":"2","author":"Shibahara","year":"2011","journal-title":"Surg. Neurol. Int."},{"key":"ref_9","first-page":"698","article-title":"Surgical managements of peripheral intracranial aneurysms","volume":"94","author":"Wu","year":"2014","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1136\/neurintsurg-2017-013603","article-title":"Infectious intracranial aneurysms: A systematic review of epidemiology, management, and outcomes","volume":"10","author":"Alawieh","year":"2018","journal-title":"J. NeuroInterv. Surg."},{"key":"ref_11","first-page":"355","article-title":"Endovascular Treatment of Peripheral Intracranial Aneurysms","volume":"28","author":"Andreou","year":"2007","journal-title":"Am. J. Neuroradiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"511.e1","DOI":"10.1016\/j.wneu.2015.10.016","article-title":"Endovascular Treatment of a Fusiform Aneurysm at the M3-M4 Junction of the Middle Cerebral Artery Using the Pipeline Embolization Device","volume":"86","author":"Durst","year":"2016","journal-title":"World Neurosurg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3171\/2013.12.JNS13945","article-title":"Endovascular treatment of fusiform cerebral aneurysms with the Pipeline Embolization Device","volume":"120","author":"Monteith","year":"2014","journal-title":"J. Neurosurg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/159101990300900303","article-title":"Glubran 2((r)): A new acrylic glue for neuroradiological endovascular use: A complementary histological study","volume":"9","author":"Leonardi","year":"2003","journal-title":"Interv. Neuroradiol."},{"key":"ref_15","first-page":"1128","article-title":"Endovascular Occlusion of the Posterior Cerebral Artery for the Treatment of P2 Segment Aneurysms: Retrospective Review of a 10-Year Series","volume":"23","author":"Hallacq","year":"2002","journal-title":"Am. J. Neuroradiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/0028-3886.280635","article-title":"Posterior Cerebral Artery Aneurysms: Parent Vessel Occlusion Being a Viable Option in the Era of Flowdivertors","volume":"68","author":"Singh","year":"2020","journal-title":"Neurol. India"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.3988\/jcn.2020.16.4.624","article-title":"Clinical Features and Outcomes of Intracranial Aneurysm Associated with Moyamoya Disease","volume":"16","author":"Kim","year":"2020","journal-title":"J. Clin. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/02688697.2020.1781058","article-title":"Treatment strategies of ruptured intracranial aneurysms associated with moyamoya disease","volume":"35","author":"Zhao","year":"2020","journal-title":"Br. J. Neurosurg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.3171\/2017.3.JNS162290","article-title":"Treatment of aneurysms in patients with moyamoya disease: A 10-year single-center experience","volume":"128","author":"Ni","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e749","DOI":"10.1016\/j.wneu.2020.03.072","article-title":"Intracranial Aneurysms in White Patients with Moyamoya Disease: A U.S. Single-Center Case Series and Review","volume":"138","author":"Larson","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s10143-020-01307-1","article-title":"Location-based treatment of intracranial aneurysms in moyamoya disease: A systematic review and descriptive analysis","volume":"44","author":"Larson","year":"2021","journal-title":"Neurosurg. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.wneu.2019.02.193","article-title":"Short-Term Spontaneous Resolution of Ruptured Peripheral Aneurysm in Moyamoya Disease","volume":"126","author":"Yamada","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10143-020-01261-y","article-title":"The prospects and pitfalls in the endovascular treatment of moyamoya disease-associated in-tra-cranial aneurysms","volume":"44","author":"Hou","year":"2021","journal-title":"Neurosurg. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1007\/s00701-016-2957-3","article-title":"Arterial aneurysms associated with arteriovenous malformations of the brain: Classi-fica-tion, incidence, risk of hemorrhage, and treatment-a systematic review","volume":"158","author":"Cagnazzo","year":"2016","journal-title":"Acta Neurochir."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3171\/jns.1998.89.4.0539","article-title":"Arterial aneurysms associated with cerebral arteriovenous malformations: Classification, incidence, and risk of hemorrhage","volume":"89","author":"Redekop","year":"1998","journal-title":"J. Neurosurg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/cns.13200","article-title":"Risk factors for hemorrhage of brain arteriovenous malformation","volume":"25","author":"Shaligram","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.3171\/2014.6.FOCUS14165","article-title":"Management of intracranial aneurysms associated with arteriovenous malfor-mations","volume":"37","author":"Flores","year":"2014","journal-title":"Neurosurg. Focus."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/9\/1264\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:34:05Z","timestamp":1760142845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/9\/1264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,19]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["brainsci12091264"],"URL":"https:\/\/doi.org\/10.3390\/brainsci12091264","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,19]]}}}