{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:09:44Z","timestamp":1790795384190,"version":"4.1.0"},"reference-count":66,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID, Chile)","award":["BASAL FB0008"],"award-info":[{"award-number":["BASAL FB0008"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID, Chile)","award":["FONDECYT 1201342"],"award-info":[{"award-number":["FONDECYT 1201342"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID, Chile)","award":["ANILLO ACT210053"],"award-info":[{"award-number":["ANILLO ACT210053"]}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID, Chile)","award":["PMI UVA1401 Ger\u00f3polis-UV"],"award-info":[{"award-number":["PMI UVA1401 Ger\u00f3polis-UV"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is the main cause of dementia worldwide. Emerging non-invasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out to evaluate the effect of transcranial light therapy (TLTC) on synaptic plasticity (SP) and cognitive functions in an AD animal model. Twenty-three mice were separated into two general groups: an APP\/PS1 (ALZ) transgenic group and a wild-type (WT) group. Each group was randomly subdivided into two subgroups: mice with and without TLTC, depending on whether they would undergo treatment with TLTC. Cognitive function, measured through an object recognition task, showed non-significant improvement after TLTC. SP, on the other hand, was evaluated using four electrophysiological parameters from the Schaffer-CA1 collateral hippocampal synapses: excitatory field potentials (fEPSP), paired pulse facilitation (PPF), long-term depression (LTD), and long-term potentiation (LTP). An improvement was observed in subjects treated with TLTC, showing higher levels of LTP than those transgenic mice that were not exposed to the treatment. Therefore, the results obtained in this work showed that TLTC could be an efficient non-invasive treatment for AD-associated SP deficits.<\/jats:p>","DOI":"10.3390\/brainsci12101272","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T21:22:23Z","timestamp":1663795343000},"page":"1272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer\u2019s Disease Mouse Model"],"prefix":"10.3390","volume":"12","author":[{"given":"D\u00e9bora","family":"Buend\u00eda","sequence":"first","affiliation":[{"name":"Programa de Engenharia Biom\u00e9dica, Instituto de Engenharia Biom\u00e9dica, Universidade Anhembi Morumbi\u2014UAM, Rua Casa do Ator, 294, Sao Paulo 04546-001, Brazil"},{"name":"Escuela de Ingenier\u00eda Civil Biom\u00e9dica, Facultad de Ingenier\u00eda, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso 2362905, Chile"},{"name":"Centro de Neurolog\u00eda Traslacional, Facultad de Medicina, Universidad de Valpara\u00edso, Valpara\u00edso 2341386, Chile"},{"name":"Centro de Inova\u00e7\u00e3o, Tecnolog\u00eda e Educa\u00e7\u00e3o\u2014CIT\u00c9, Parque Tecnol\u00f3gico de S\u00e3o Jos\u00e9 dos Campos, Estrada Dr. Altino Bondesan 500, S\u00e3o Jos\u00e9 dos Campos 12247-016, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Guncay","sequence":"additional","affiliation":[{"name":"Centro de Neurolog\u00eda Traslacional, Facultad de Medicina, Universidad de Valpara\u00edso, Valpara\u00edso 2341386, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Oyanedel","sequence":"additional","affiliation":[{"name":"Escuela de Ingenier\u00eda Civil Biom\u00e9dica, Facultad de Ingenier\u00eda, Universidad de Valpara\u00edso, General Cruz 222, Valpara\u00edso 2362905, 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Neurociencia de Valpara\u00edso, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso 2360102, Chile"},{"name":"Escuela de Medicina, Facultad de Medicina, Universidad de Valpara\u00edso, Angamos 655, Vi\u00f1a del Mar 2540064, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-610X","authenticated-orcid":false,"given":"Jos\u00e9","family":"Marcos","sequence":"additional","affiliation":[{"name":"Centro de Neurolog\u00eda Traslacional, Facultad de Medicina, Universidad de Valpara\u00edso, Valpara\u00edso 2341386, Chile"},{"name":"Escuela de Ciencias Agr\u00edcolas y Veterinarias, Universidad Vi\u00f1a del Mar, Vi\u00f1a del Mar 2572007, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-1299","authenticated-orcid":false,"given":"Adriana","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Programa de Engenharia Biom\u00e9dica, Instituto de 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