{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:40:28Z","timestamp":1792100428993,"version":"4.4.0"},"reference-count":52,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei province","doi-asserted-by":"publisher","award":["WJ2019Z008"],"award-info":[{"award-number":["WJ2019Z008"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei province","doi-asserted-by":"publisher","award":["2020JZKT651"],"award-info":[{"award-number":["2020JZKT651"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Natural Science Foundation of Tongji Hospital","award":["WJ2019Z008"],"award-info":[{"award-number":["WJ2019Z008"]}]},{"name":"The Natural Science Foundation of Tongji Hospital","award":["2020JZKT651"],"award-info":[{"award-number":["2020JZKT651"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Objective: To analyze the risk factors of transient neurological deficits (TND) and perioperative stroke in patients with MMD after extracranial\u2013intracranial revascularization. Methods: A retrospective analysis of the clinical data of 183 patients with MMD undergoing 203 EC\u2013IC bypass operation procedures from January 2018 to August 2020. According to whether TND and stroke occurred within 14 days after operation, univariate analysis and multivariate logistic regression were used. Results: TND occurred in 26 cases (12.8%) of revascularization. The results of the univariate analysis showed that history of diabetes, multiple episodes of preoperative symptoms, lesions involving the posterior circulation, and high postoperative blood pressure are the risk factors of TND. Further multivariate logistic regression analysis showed that multiple episodes of preoperative symptoms (p = 0.016) and lesions involving the posterior circulation (p = 0.014) are the independent risk factors for TND. Perioperative stroke occurred in 12 cases (5.9%). The results of the univariate analysis showed that older age, history of hypertension, preoperative cerebral infarction as the main symptom, lesions involving the posterior circulation, and high perioperative blood pressure are the risk factors of perioperative stroke. The results of multivariate logistic regression analysis showed that preoperative cerebral infarction as the main symptom (p = 0.015) is an independent risk factor for perioperative stroke. The occurrence of perioperative complications was not related to the improvement of follow-up mRS (Modified Rankin Scale) score and long-term cerebral rehemorrhage. Conclusions: Clinically, patients with MMD have multiple episodes of preoperative symptoms, lesions involving the posterior circulation, and preoperative cerebral infarction and should be attached when undergoing revascularization.<\/jats:p>","DOI":"10.3390\/brainsci12101285","type":"journal-article","created":{"date-parts":[[2022,9,25]],"date-time":"2022-09-25T21:14:28Z","timestamp":1664140468000},"page":"1285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Risk Factors of Transient Neurological Deficits and Perioperative Stroke after Revascularization in Patients with Moyamoya Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-6775","authenticated-orcid":false,"given":"Xincheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3241-7567","authenticated-orcid":false,"given":"Ting","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-2040","authenticated-orcid":false,"given":"Huaqiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","article-title":"Cerebrovascular \u201cmoyamoya\u201d disease. Disease showing abnormal net-like vessels in base of brain","volume":"20","author":"Suzuki","year":"1969","journal-title":"Arch. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sun, Y., Zhou, G., Feng, J., Chen, L., Liu, G., Wang, J., Wang, Q., Yu, J., Yang, X., and Yang, Z. (2021). Incidence and prevalence of moyamoya disease in urban China: A nationwide retrospective cohort study. Stroke Vasc. Neurol., 6.","DOI":"10.1136\/svn-2021-000909"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e917","DOI":"10.1016\/j.wneu.2018.10.175","article-title":"Epidemiology of Moyamoya Disease in China: Single-Center, Population-Based Study","volume":"122","author":"Bao","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1161\/STROKEAHA.110.598565","article-title":"Neurosurgical advances in the treatment of moyamoya disease","volume":"42","author":"Pandey","year":"2011","journal-title":"Stroke"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"(2012). Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis). Neurol. Med. Chir., 52, 245\u2013266.","DOI":"10.2176\/nmc.52.245"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.wneu.2019.04.062","article-title":"Meta-Analysis of Prognosis of Different Treatments for Symptomatic Moyamoya Disease","volume":"127","author":"Li","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1227\/NEU.0b013e318208f1da","article-title":"Significance of focal cerebral hyperperfusion as a cause of transient neurologic deterioration after extracranial-intracranial bypass for moyamoya disease: Comparative study with non-moyamoya patients using N-isopropyl-p-[(123)I]iodoamphetamine single-photon emission computed tomography","volume":"68","author":"Fujimura","year":"2011","journal-title":"Neurosurgery"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.wneu.2019.11.065","article-title":"Cerebral Hyperperfusion Syndrome After Revascularization Surgery in Patients with Moyamoya Disease: Systematic Review and Meta-Analysis","volume":"135","author":"Yu","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/STROKEAHA.107.490714","article-title":"Prevalence and clinicoepidemiological features of moyamoya disease in Japan: Findings from a nationwide epidemiological survey","volume":"39","author":"Kuriyama","year":"2008","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.7461\/jcen.2012.14.3.262","article-title":"Prevalence and epidemiological features of moyamoya disease in Korea","volume":"14","author":"Im","year":"2012","journal-title":"J. Cerebrovasc. Endovasc. Neurosurg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3171\/2014.10.JNS132369","article-title":"Clinical features and long-term outcomes of moyamoya disease: A single-center experience with 528 cases in China","volume":"122","author":"Liu","year":"2015","journal-title":"J. Neurosurg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000343225","article-title":"Clinical features, surgical treatment and long-term outcome in adult patients with Moyamoya disease in China","volume":"34","author":"Bao","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1016\/j.wneu.2018.06.125","article-title":"Risk Factors Associated with Neurologic Deterioration After Combined Direct and Indirect Revascularization in Patients with Moyamoya Disease on the East Coast of China","volume":"118","author":"Zhai","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1159\/000132205","article-title":"Transient hyperperfusion after superficial temporal artery\/middle cerebral artery bypass surgery as a possible cause of postoperative transient neurological deterioration","volume":"25","author":"Kim","year":"2008","journal-title":"Cerebrovasc. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.surneu.2007.01.047","article-title":"Postoperative temporary neurological deficits in adults with moyamoya disease","volume":"69","author":"Ohue","year":"2008","journal-title":"Surg. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.surneu.2006.07.017","article-title":"Temporary neurologic deterioration due to cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in patients with adult-onset moyamoya disease","volume":"67","author":"Fujimura","year":"2007","journal-title":"Surg. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2176\/nmc.52.327","article-title":"Lessons learned from moyamoya disease: Outcome of direct\/indirect revascularization surgery for 150 affected hemispheres","volume":"52","author":"Fujimura","year":"2012","journal-title":"Neurol. Med. Chir."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/BF01404844","article-title":"Peri-operative complications in adult moyamoya disease","volume":"132","author":"Iwama","year":"1995","journal-title":"Acta Neurochir."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"420","DOI":"10.2176\/nmc.38.420","article-title":"Hyperperfusion syndrome after extracranial-intracranial bypass in a patient with moyamoya disease\u2014Case report","volume":"38","author":"Uno","year":"1998","journal-title":"Neurol. Med. Chir."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3171\/2010.4.PEDS09478","article-title":"Postoperative neurological deterioration in pediatric moyamoya disease: Watershed shift and hyperperfusion","volume":"6","author":"Hayashi","year":"2010","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3171\/2014.8.JNS132413","article-title":"Is local hypoperfusion the reason for transient neurological deficits after STA-MCA bypass for moyamoya disease?","volume":"122","author":"Mukerji","year":"2015","journal-title":"J. Neurosurg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3988\/jcn.2018.14.3.393","article-title":"Postoperative Transient Neurologic Dysfunction: A Proposal for Pathophysiology","volume":"14","author":"Phi","year":"2018","journal-title":"J. Clin. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.wneu.2017.07.037","article-title":"Postoperative Dilatation of Superficial Temporal Artery Associated with Transient Neurologic Symptoms After Direct Bypass Surgery for Moyamoya Angiopathy","volume":"106","author":"Ishii","year":"2017","journal-title":"World Neurosurg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"104846","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104846","article-title":"Postoperative Functional Outcomes and Prognostic Factors in Two Types of Adult Moyamoya Diseases","volume":"29","author":"Zhang","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis. Off. J. Natl. Stroke Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3171\/2014.1.JNS13946","article-title":"The frequency of postoperative stroke in moyamoya disease following combined revascularization: A single-university series and systematic review","volume":"121","author":"Kazumata","year":"2014","journal-title":"J. Neurosurg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3171\/2017.10.JNS171749","article-title":"Risk factors for and outcomes of postoperative complications in adult patients with moyamoya disease","volume":"130","author":"Zhao","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1016\/j.wneu.2018.01.212","article-title":"Postoperative Cerebral Infarction Risk Factors and Postoperative Management of Pediatric Patients with Moyamoya Disease","volume":"113","author":"Muraoka","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.wneu.2016.03.053","article-title":"Risk Factors for Newly Developed Cerebral Infarction After Surgical Revascularization for Adults with Moyamoya Disease","volume":"92","author":"Park","year":"2016","journal-title":"World Neurosurg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10143-009-0184-6","article-title":"Cerebral ischemia owing to compression of the brain by swollen temporal muscle used for encephalo-myo-synangiosis in moyamoya disease","volume":"32","author":"Fujimura","year":"2009","journal-title":"Neurosurg. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3171\/2018.8.JNS18951","article-title":"Contralateral acute vascular occlusion following revascularization surgery for moyamoya disease","volume":"131","author":"Sussman","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e593","DOI":"10.1016\/j.wneu.2018.08.132","article-title":"Postoperative Intracerebral Hemorrhage After Combined Revascularization Surgery in Moyamoya Disease: Profiles and Clinical Associations","volume":"120","author":"Tokairin","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.3171\/2019.7.JNS19885","article-title":"Postoperative hemorrhage during the acute phase after direct or combined revascularization for moyamoya disease: Risk factors, prognosis, and literature review","volume":"133","author":"Chen","year":"2019","journal-title":"J. Neurosurg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e774","DOI":"10.1016\/j.wneu.2018.07.266","article-title":"Intracranial Hemorrhage After Superficial Temporal Artery-Middle Cerebral Artery Direct Anastomosis for Adults with Moyamoya Disease","volume":"119","author":"Park","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3171\/2016.6.JNS16653","article-title":"Topographic changes in cerebral blood flow and reduced white matter integrity in the first 2 weeks following revascularization surgery in adult moyamoya disease","volume":"127","author":"Kazumata","year":"2017","journal-title":"J. Neurosurg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.surneu.2007.07.077","article-title":"Delayed intracerebral hemorrhage after superficial temporal artery-middle cerebral artery anastomosis in a patient with moyamoya disease: Possible involvement of cerebral hyperperfusion and increased vascular permeability","volume":"71","author":"Fujimura","year":"2009","journal-title":"Surg. Neurol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1159\/000336765","article-title":"Efficacy of prophylactic blood pressure lowering according to a standardized postoperative management protocol to prevent symptomatic cerebral hyperperfusion after direct revascularization surgery for moyamoya disease","volume":"33","author":"Fujimura","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.wneu.2017.03.146","article-title":"Ischemic Stroke in Young Adults with Moyamoya Disease: Prognostic Factors for Stroke Recurrence and Functional Outcome after Revascularization","volume":"103","author":"Zhao","year":"2017","journal-title":"World Neurosurg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.04.004","article-title":"Diabetes is an Independent Risk Factor for Stroke Recurrence in Stroke Patients: A Meta-analysis","volume":"24","author":"Shou","year":"2015","journal-title":"J. Stroke Cerebrovasc. Dis. Off. J. Natl. Stroke Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00701-010-0638-1","article-title":"Prognostic factors associated with perioperative ischemic complications in adult-onset moyamoya disease","volume":"152","author":"Hyun","year":"2010","journal-title":"Acta Neurochir."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3171\/jns.1984.61.6.1032","article-title":"Study of the posterior circulation in moyamoya disease. Clinical and neuroradiological evaluation","volume":"61","author":"Miyamoto","year":"1984","journal-title":"J. Neurosurg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e582","DOI":"10.1016\/j.wneu.2019.04.214","article-title":"Revascularization Surgery in Patients with Ischemic-Type Moyamoya Disease: Predictors for Postoperative Stroke and Long-Term Outcomes","volume":"128","author":"Yu","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3171\/2016.11.JNS161688","article-title":"Meta-analysis of the surgical outcomes of symptomatic moyamoya disease in adults","volume":"128","author":"Jeon","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000504835","article-title":"Significance of Quantitative Cerebral Blood Flow Measurement in the Acute Stage after Revascularization Surgery for Adult Moyamoya Disease: Implication for the Pathological Threshold of Local Cerebral Hyperperfusion","volume":"48","author":"Kameyama","year":"2019","journal-title":"Cerebrovasc. Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/bja\/aes470","article-title":"Predictive factors of symptomatic cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in adult patients with moyamoya disease","volume":"110","author":"Hwang","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"105413","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105413","article-title":"Individualized Perioperative Blood Pressure Management for Adult Moyamoya Disease: Experience from 186 Consecutive Procedures","volume":"30","author":"Li","year":"2021","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1016\/j.wneu.2018.04.148","article-title":"Quantitative Blood Flow Assessment by Multiparameter Analysis of Indocyanine Green Video Angiography","volume":"116","author":"Saito","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_47","first-page":"8561609","article-title":"Evaluation of Hemodynamic Change by Indocyanine Green-FLOW 800 Videoangiography Mapping: Prediction of Hyperperfusion Syndrome in Patients with Moyamoya Disease","volume":"2020","author":"Zhang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.wneu.2018.03.189","article-title":"Assessment of Hemodynamic Changes and Hyperperfusion Risk After Extracranial-to-Intracranial Bypass Surgery Using Intraoperative Indocyanine Green-Based Flow Analysis","volume":"114","author":"Rennert","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10143-017-0845-9","article-title":"Uneven cerebral hemodynamic change as a cause of neurological deterioration in the acute stage after direct revascularization for moyamoya disease: Cerebral hyperperfusion and remote ischemia caused by the \u2018watershed shift\u2019","volume":"40","author":"Tu","year":"2017","journal-title":"Neurosurg. Rev."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00008506-199801000-00009","article-title":"Postoperative neurological deterioration following the revascularization surgery in children with moyamoya disease","volume":"10","author":"Sakamoto","year":"1998","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1161\/STROKEAHA.116.013304","article-title":"Edaravone Reduces Hyperperfusion-Related Neurological Deficits in Adult Moyamoya Disease: Historical Control Study","volume":"47","author":"Uchino","year":"2016","journal-title":"Stroke"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1227\/NEU.0000000000000238","article-title":"Minocycline prevents focal neurological deterioration due to cerebral hyperperfusion after extracranial-intracranial bypass for moyamoya disease","volume":"74","author":"Fujimura","year":"2014","journal-title":"Neurosurgery"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/10\/1285\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:38:27Z","timestamp":1760143107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/10\/1285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,23]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["brainsci12101285"],"URL":"https:\/\/doi.org\/10.3390\/brainsci12101285","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,23]]}}}