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The current study explores whether heterogeneity in EF profiles can be detected within a sample of children with DS. Participants were 69 children with DS, ages 3\u201310 years (M = 6.23, SD = 1.91). T-scores from a caregiver-report measure of executive function were modeled using latent profile analysis, and auxiliary analyses examined the association between demographic and biomedical factors and probability of profile membership. The two-profile solution was the best fit for the sample, with a profile that involved elevated scores in working memory only (\u201cWorking Memory Only\u201d profile; 43% of sample) and a \u201cMulti-Domain\u201d profile that involved elevated scores in planning, inhibition, and working memory (57%). The presence of congenital heart defects was associated with a higher probability of assignment to the Multi-Domain profile. Findings from this study contribute to the characterization of heterogeneous outcomes associated with DS.<\/jats:p>","DOI":"10.3390\/brainsci12101333","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:07:43Z","timestamp":1665187663000},"page":"1333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Profiles of Caregiver-Reported Executive Function in Children with Down Syndrome"],"prefix":"10.3390","volume":"12","author":[{"given":"Kaylyn","family":"Van Deusen","sequence":"first","affiliation":[{"name":"Human Development and Family Studies, Colorado State University, Fort Collins, CO 80523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8848-0568","authenticated-orcid":false,"given":"Mark A.","family":"Prince","sequence":"additional","affiliation":[{"name":"Department of Psychology, Colorado State University, Fort Collins, CO 80523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-7791","authenticated-orcid":false,"given":"Anna J.","family":"Esbensen","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie O.","family":"Edgin","sequence":"additional","affiliation":[{"name":"Sonoran University Center for Excellence in Developmental Disabilities, University of Arizona, Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-339X","authenticated-orcid":false,"given":"Emily K.","family":"Schworer","sequence":"additional","affiliation":[{"name":"Division of Developmental and Behavioral Pediatrics, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Waisman Center, University of Wisconsin\u2014Madison, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela John","family":"Thurman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, MIND Institute, University of California Davis Health, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Colorado-Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Daunhauer","sequence":"additional","affiliation":[{"name":"Human Development and Family Studies, Colorado State University, Fort Collins, CO 80523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6208-456X","authenticated-orcid":false,"given":"Deborah J.","family":"Fidler","sequence":"additional","affiliation":[{"name":"Human Development and Family Studies, Colorado State University, Fort Collins, CO 80523, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101600","DOI":"10.1016\/j.intell.2021.101600","article-title":"The factor structure of executive function in childhood and adolescence","volume":"90","author":"Laureys","year":"2022","journal-title":"Intelligence"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/0963721411429458","article-title":"The nature and organization of individual differences in executive functions: Four general conclusions","volume":"21","author":"Miyake","year":"2012","journal-title":"Curr. 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