{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:12:52Z","timestamp":1792638772052,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Obstructive sleep apnoea (OSA) has an important impact on the risk of morbidity and mortality, so we have designed the present study to understand which factor is most involved in the risk of developing a comorbidity between OSA severity and nocturnal hypoxemia. Methods: A retrospective study was conducted on 617 adult subjects who were referred to our unit for a suspicion of OSA between January 2018 and January 2020. Results: Sleep investigations performed by participants (72% male and obese in 70% of cases) reported an overall mean apnoea\u2013hypopnoea index (AHI) of 44.0 \u00b1 24.8 events\u00b7h\u22121. Overall, 66% were classified as severe OSA and 76% experienced nocturnal hypoxemia. By analysing the burden of OSA severity and nocturnal hypoxemia on the comorbidities risk, multivariate analysis highlighted the predominant role of age and obesity. Accordingly, after the exclusion of the older and obese participants from the analyses, we noticed that severe OSA was related to the risk of hypertension (odds ratio (OR) = 3.0 [95% confidence interval [CI] 1.4\u20136.2], p = 0.004) as well as nocturnal hypoxemia (OR = 2.6 [95% CI 1.2\u20135.4], p = 0.01). Conclusions: The study seems to suggest that in young, non-obese subjects, OSA is a predisposing factor for the risk of developing hypertension.<\/jats:p>","DOI":"10.3390\/brainsci12101359","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T00:07:43Z","timestamp":1665187663000},"page":"1359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Burden of Respiratory Alterations during Sleep on Comorbidities in Obstructive Sleep Apnoea (OSA)"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1202-8567","authenticated-orcid":false,"given":"Pasquale","family":"Tondo","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"},{"name":"Respiratory and Intensive Care Unit, Department of Specialistic Medicine, \u201cPoliclinico Foggia\u201d University Hospital, 71122 Foggia, Italy"},{"name":"Respiratory Function and Sleep Medicine Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8601-423X","authenticated-orcid":false,"given":"Francesco","family":"Fanfulla","sequence":"additional","affiliation":[{"name":"Respiratory Function and Sleep Medicine Unit, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2667-077X","authenticated-orcid":false,"given":"Giulia","family":"Scioscia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"},{"name":"Respiratory and Intensive Care Unit, Department of Specialistic Medicine, \u201cPoliclinico Foggia\u201d University Hospital, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sabato","sequence":"additional","affiliation":[{"name":"Respiratory and Intensive Care Unit, Department of Specialistic Medicine, \u201cPoliclinico Foggia\u201d University Hospital, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Salvemini","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"},{"name":"Respiratory and Intensive Care Unit, Department of Specialistic Medicine, \u201cPoliclinico Foggia\u201d University Hospital, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9777-5598","authenticated-orcid":false,"given":"Cosimo C.","family":"De Pace","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"},{"name":"Respiratory and Intensive Care Unit, Department of Specialistic Medicine, \u201cPoliclinico Foggia\u201d University Hospital, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Foschino Barbaro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"},{"name":"Respiratory and Intensive Care Unit, Department of Specialistic Medicine, \u201cPoliclinico Foggia\u201d University Hospital, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-7967","authenticated-orcid":false,"given":"Donato","family":"Lacedonia","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"},{"name":"Respiratory and Intensive Care Unit, Department of Specialistic Medicine, \u201cPoliclinico Foggia\u201d University Hospital, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tondo, P., Fanfulla, F., Sabato, R., Scioscia, G., Foschino Barbaro, M.P., and Lacedonia, D. 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