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Since it occurs prevalently in neurosurgical patients and poses great threats to the well-being of patients, much emphasis is placed on POD in neurosurgical units. However, there are intricate theories about its pathogenesis and limited pharmacological interventions for POD. In this study, we review the recent insights into its pathogenesis, mainly based on studies within five years, and the five dominant pathological theories that account for the development of POD, with the intention of furthering our understanding and boosting its clinical management.<\/jats:p>","DOI":"10.3390\/brainsci12101371","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T20:49:31Z","timestamp":1665348571000},"page":"1371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Postoperative Delirium in Neurosurgical Patients: Recent Insights into the Pathogenesis"],"prefix":"10.3390","volume":"12","author":[{"given":"Yinuo","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China"},{"name":"School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianquan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China"},{"name":"Center for Precision Neurosurgery and Oncology, Peking University Health Science Center, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8102-8811","authenticated-orcid":false,"given":"Chenlong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China"},{"name":"Center for Precision Neurosurgery and Oncology, Peking University Health Science Center, Beijing 100191, China"},{"name":"North America Medical Education Foundation, Union City, CA 94587, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China"},{"name":"Center for Precision Neurosurgery and Oncology, Peking University Health Science Center, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,9]]},"reference":[{"key":"ref_1","unstructured":"Association, A.P. 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