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Technology Projects in Guangzhou","award":["202201010147"],"award-info":[{"award-number":["202201010147"]}]},{"name":"Science and Technology Projects in Guangzhou","award":["202102020573"],"award-info":[{"award-number":["202102020573"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Isofraxidin is an active component of several traditional and functional plants that have beneficial properties for neurodegenerative diseases. In this study, we examined whether isofraxidin exhibited antidepressant-like effects in chronic unpredictable mild stress (CUMS)-induced mice. Firstly, isofraxidin could reverse CUMS-induced decrease in body weight gain in mice. Additionally, in the sucrose preference test (SPT), isofraxidin reversed the decrease in sucrose consumption due to CUMS-induced depressive-like behavior. Isofraxidin also increased locomotor activity in the open field test (OFT) and alleviated immobility duration in the forced swimming test (FST) and tail-suspension test (TST). Furthermore, isofraxidin decreased levels of corticosterone (CORT), adrenocorticotropic hormone (ACTH), and hypothalamus corticotrophin-releasing hormone (CRH) in the serum after CUMS-induced hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Also, isofraxidin suppresses tumor necrosis factor (TNF)-\u03b1, interleukin (IL)-1\u03b2, and IL-6 expression in the hippocampus of CUMS mice. Further investigations demonstrated that isofraxidin inhibited CUMS-induced activation of nuclear factor kappa B (NF-\u03baB) and NOD-like receptor protein 3 (NLRP3) inflammasomes in the hippocampus. Summarily, in CUMS-induced mice, isofraxidin reduced depressive-like behaviors, accompanied by its inhibitory effects on hyperactivity of the HPA axis and NF-\u03baB \/NLRP3 inflammasomes pathways.<\/jats:p>","DOI":"10.3390\/brainsci12101376","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T06:13:27Z","timestamp":1665468807000},"page":"1376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Suppressive Effects of Isofraxidin on Depressive-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Xiaoli","family":"Wu","sequence":"first","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicong","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghui","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-8135","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Automation, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-8188","authenticated-orcid":false,"given":"Chuwen","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1001\/archpsyc.65.12.1394","article-title":"Incidence and Recurrence of Late-Life Depression","volume":"65","author":"Luijendijk","year":"2008","journal-title":"Arch. Gen. Psychiatary"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/mp.2016.120","article-title":"HPA axis in major depression: Cortisol, clinical symptomatology and genetic variation predict cognition","volume":"22","author":"Keller","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jad.2017.09.052","article-title":"Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review","volume":"233","author":"Juruena","year":"2018","journal-title":"J. Affect Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/10253890.2016.1174851","article-title":"Activation of the HPA axis and depression of feeding behavior induced by restraint stress are separately regulated by PACAPergic neurotransmission in the mouse","volume":"19","author":"Jiang","year":"2016","journal-title":"Stress"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpsychires.2016.03.009","article-title":"In search of the HPA axis activity in unipolar depression patients with childhood trauma: Combined cortisol awakening response and dexamethasone suppression test","volume":"78","author":"Lu","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mikulska, J., Juszczyk, G., Gawronska-Grzywacz, M., and Herbet, M. (2021). HPA Axis in the Pathomechanism of Depression and Schizophrenia: New Therapeutic Strategies Based on Its Participation. Brain. Sci., 11.","DOI":"10.3390\/brainsci11101298"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: Classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.physbeh.2016.03.017","article-title":"Chronic unpredictable mild stress generates oxidative stress and systemic inflammation in rats","volume":"161","author":"Jaime","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/187152808784165216","article-title":"Inflammatory aspects of depression","volume":"7","author":"Adler","year":"2008","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/cns.12230","article-title":"NLRP3 Inflammasome: A New Target in Major Depressive Disorder","volume":"20","author":"Cordero","year":"2014","journal-title":"Cns. Neurosci. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2013.10.017","article-title":"NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder","volume":"36","author":"Cordero","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnmol.2015.00077","article-title":"NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review","volume":"8","author":"Shih","year":"2015","journal-title":"Front Mol. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function Amd Activation of Nf-Kappa-B in the Immune-System","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: The control of NF-kappa B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Dionisie, V., Ciobanu, A.M., Toma, V.A., Manea, M.C., Baldea, I., Olteanu, D., Sevastre-Berghian, A., Clichici, S., Manea, M., and Riga, S. (2021). Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147483"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Rafa\u0142o-Uli\u0144ska, A., Bra\u0144ski, P., and Pa\u0142ucha-Poniewiera, A. (2022). Combined Administration of (R)-Ketamine and the mGlu2\/3 Receptor Antagonist LY341495 Induces Rapid and Sustained Effects in the CUMS Model of Depression via a TrkB\/BDNF-Dependent Mechanism. Pharmaceuticals, 15.","DOI":"10.3390\/ph15020125"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhang, M.M., Huo, G.M., Cheng, J., Zhang, Q.P., Li, N.Z., Guo, M.X., Liu, Q., Xu, G.H., Zhu, J.X., and Li, C.F. (2022). Gypenoside XVII, an Active Ingredient from Gynostemma Pentaphyllum, Inhibits C3aR-Associated Synaptic Pruning in Stressed Mice. Nutrients, 14.","DOI":"10.3390\/nu14122418"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4416","DOI":"10.1039\/C9FO02602A","article-title":"Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db\/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway","volume":"11","author":"Li","year":"2020","journal-title":"Food Funct"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Majnooni, M.B., Fakhri, S., Shokoohinia, Y., Mojarrab, M., Kazemi-Afrakoti, S., and Farzaei, M.H. (2020). Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties. Molecules, 25.","DOI":"10.3390\/molecules25092040"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lian, B., Gu, J., Zhang, C., Zou, Z., Yu, M., Li, F., Wu, X., and Zhao, A.Z. (2022). Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling pathway. Metab. Brain Dis.","DOI":"10.21203\/rs.3.rs-1364657\/v1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"963689721990321","DOI":"10.1177\/0963689721990321","article-title":"Isofraxidin Inhibits Receptor Activator of Nuclear Factor-kappaB Ligand-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages Isolated from Sprague-Dawley Rats by Regulating NF-kappaB\/NFATc1 and Akt\/NFATc1 Signaling Pathways","volume":"30","author":"Wang","year":"2021","journal-title":"Cell Transpl."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.imbio.2014.10.007","article-title":"Isofraxidin protects mice from LPS challenge by inhibiting pro-inflammatory cytokines and alleviating histopathological changes","volume":"220","author":"Liu","year":"2015","journal-title":"Immunobiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1007\/s10753-019-01158-z","article-title":"Isofraxidin Alleviates Myocardial Infarction Through NLRP3 Inflammasome Inhibition","volume":"43","author":"Chen","year":"2020","journal-title":"Inflammation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s10495-014-0984-1","article-title":"Isofraxidin, a potent reactive oxygen species (ROS) scavenger, protects human leukemia cells from radiation-induced apoptosis via ROS\/mitochondria pathway in p53-independent manner","volume":"19","author":"Li","year":"2014","journal-title":"Apoptosis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.phytochem.2012.02.023","article-title":"Dihydrochalcone glucosides and antioxidant activity from the roots of Anneslea fragrans var. lanceolata","volume":"78","author":"Huang","year":"2012","journal-title":"Phytochemistry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8745","DOI":"10.1021\/acs.jafc.6b03568","article-title":"Effect of Coffee in Lipopolysaccharide-Induced Indoleamine 2,3-Dioxygenase Activation and Depressive-like Behavior in Mice","volume":"64","author":"Hall","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6473506","DOI":"10.1155\/2017\/6473506","article-title":"Ginsenoside Rg1 Ameliorates Behavioral Abnormalities and Modulates the Hippocampal Proteomic Change in Triple Transgenic Mice of Alzheimer\u2019s Disease","volume":"2017","author":"Nie","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1039\/C8FO02474J","article-title":"Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice","volume":"10","author":"Wu","year":"2019","journal-title":"Food Funct."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fpsyt.2015.00006","article-title":"An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL\/6 mice","volume":"6","author":"Monteiro","year":"2015","journal-title":"Front Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lippi, S.L.P. (2021). Chronic Mild Unpredictable Stress and High-Fat Diet Given during Adolescence Impact Both Cognitive and Noncognitive Behaviors in Young Adult Mice. Brain Sci., 11.","DOI":"10.3390\/brainsci11020260"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Alqurashi, G.K., Hindi, E.A., Zayed, M.A., Abd El-Aziz, G.S., Alturkistani, H.A., Ibrahim, R.F., Al-Thepyani, M.A., Bakhlgi, R., Alzahrani, N.A., and Ashraf, G.M. (2022). The Impact of Chronic Unpredictable Mild Stress-Induced Depression on Spatial, Recognition and Reference Memory Tasks in Mice: Behavioral and Histological Study. Behav. Sci., 12.","DOI":"10.3390\/bs12060166"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Bashir, M.I., Abdul Aziz, N.H.K., and Noor, D.A.M. (2022). Antidepressant-like Effects of Polygonum minus Aqueous Extract in Chronic Ultra-Mild Stress-Induced Depressive Mice Model. Behav. Sci., 12.","DOI":"10.3390\/bs12060196"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12264-010-0329-1","article-title":"Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress","volume":"26","author":"Wang","year":"2010","journal-title":"Neurosci. Bull."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1440-1819.2010.02135.x","article-title":"Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression","volume":"64","author":"Kunugi","year":"2010","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.1038\/tp.2012.120","article-title":"Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes","volume":"2","author":"Rizzo","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0006-3223(03)00173-2","article-title":"Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment","volume":"54","author":"Capuron","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jpsychores.2010.11.006","article-title":"Inflammation and treatment response to sertraline in patients with coronary heart disease and comorbid major depression","volume":"71","author":"Bot","year":"2011","journal-title":"J. Psychosom. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"76396","DOI":"10.1155\/2007\/76396","article-title":"Pro- and anti-inflammatory cytokine balance in major depression: Effect of sertraline therapy","volume":"2007","author":"Sutcigil","year":"2007","journal-title":"Clin. Dev. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2014.04.007","article-title":"Microglial NLRP3 inflammasome activation mediates IL-1 beta-related inflammation in prefrontal cortex of depressive rats","volume":"41","author":"Pan","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Tung, T.H., Chen, Y.C., Lin, Y.T., and Huang, S.Y. (2022). N-3 PUFA Ameliorates the Gut Microbiota, Bile Acid Profiles, and Neuropsychiatric Behaviours in a Rat Model of Geriatric Depression. Biomedicines, 10.","DOI":"10.3390\/biomedicines10071594"}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/10\/1376\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:49:40Z","timestamp":1760143780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/10\/1376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,11]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["brainsci12101376"],"URL":"https:\/\/doi.org\/10.3390\/brainsci12101376","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,11]]}}}