{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:02:27Z","timestamp":1776978147327,"version":"3.51.4"},"reference-count":86,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research (BMBF)","doi-asserted-by":"publisher","award":["01E01001"],"award-info":[{"award-number":["01E01001"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research (BMBF)","doi-asserted-by":"publisher","award":["BMBF 1315883"],"award-info":[{"award-number":["BMBF 1315883"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Federal Ministry of Education and Research","award":["01E01001"],"award-info":[{"award-number":["01E01001"]}]},{"name":"German Federal Ministry of Education and Research","award":["BMBF 1315883"],"award-info":[{"award-number":["BMBF 1315883"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Alterations of hypothalamic\u2013pituitary\u2013adrenal (HPA) axis activity and serotonergic signaling are implicated in the pathogenesis of human obesity and may contribute to its metabolic and mental complications. The association of these systems has not been investigated in human obesity. Objective: To investigate the relation of HPA responsiveness and serotonin transporter (5-HTT) availability in otherwise healthy individuals with obesity class II or III (OB) compared to non-obesity controls (NO). Study participants: Twenty-eight OB (21 females; age 36.6 \u00b1 10.6 years; body mass index (BMI) 41.2 \u00b1 5.1 kg\/m2) were compared to 12 healthy NO (8 females; age 35.8 \u00b1 7.4 years; BMI 22.4 \u00b1 2.3 kg\/m2), matched for age and sex. Methods: HPA axis responsiveness was investigated using the combined dexamethasone\/corticotropin-releasing hormone (dex\/CRH) test, and curve indicators were derived for cortisol and adrenocorticotropic hormone (ACTH). The 5-HTT selective tracer [11C]DASB was applied, and parametric images of the binding potentials (BPND) were calculated using the multilinear reference tissue model and evaluated by atlas-based volume of interest (VOI) analysis. The self-questionnaires of behavioral inhibition system\/behavioral activation system (BIS\/BAS) with subscales drive, fun-seeking and reward were assessed. Results: OB showed significant positive correlations of ACTH curve parameters with overall 5-HTT BPND (ACTHAUC: r = 0.39, p = 0.04) and 5-HTT BPND of the caudate nucleus (ACTHAUC: r = 0.54, p = 0.003). In NO, cortisol indicators correlated significantly with BPND in the hippocampus (cortisolAUC: r = 0.59, p = 0.04). In OB, BAS reward was inversely associated with the ACTHAUC (r = \u22120.49, p = 0.009). Conclusion: The present study supports a serotonergic-neuroendocrine association, which regionally differs between OB and NO. In OB, areas processing emotion and reward seem to be in-volved. The finding of a serotonergic HPA correlation may have implications for other diseases with dysregulated stress axis responsiveness, and for potential pharmacologic interven-tions.<\/jats:p>","DOI":"10.3390\/brainsci12111430","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T12:29:45Z","timestamp":1666700985000},"page":"1430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["HPA Axis Responsiveness Associates with Central Serotonin Transporter Availability in Human Obesity and Non-Obesity Controls"],"prefix":"10.3390","volume":"12","author":[{"given":"Christian","family":"Schinke","sequence":"first","affiliation":[{"name":"Klinik und Hochschulambulanz f\u00fcr Neurologie, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"Berlin Institute of Health at Charit\u00e9, Universit\u00e4tsmedizin Berlin, Anna-Louisa-Karsch Stra\u00dfe 2, 10178 Berlin, Germany"},{"name":"Department of Neurology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2683-9432","authenticated-orcid":false,"given":"Michael","family":"Rullmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, 04109 Leipzig, Germany"},{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Luthardt","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Drabe","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, 04109 Leipzig, Germany"},{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1112-866X","authenticated-orcid":false,"given":"Elisa","family":"Preller","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg A.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Patt","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7292-1859","authenticated-orcid":false,"given":"Ralf","family":"Regenthal","sequence":"additional","affiliation":[{"name":"Rudolf-Boehm-Institute of Pharmacology and Toxicology, Clinical Pharmacology, Faculty of Medicine, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-8872","authenticated-orcid":false,"given":"Franziska","family":"Zientek","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, 04109 Leipzig, Germany"},{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Sabri","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8604-8408","authenticated-orcid":false,"given":"Florian","family":"Then Bergh","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Leipzig, 04109 Leipzig, Germany"},{"name":"Translational Centre for Regenerative Medicine, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swen","family":"Hesse","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Leipzig, 04109 Leipzig, Germany"},{"name":"Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, 04109 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13098-019-0468-0","article-title":"Cardiovascular risk and obesity","volume":"11","author":"Cercato","year":"2019","journal-title":"Diabetol. 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