{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:56:42Z","timestamp":1783979802596,"version":"3.55.0"},"reference-count":61,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: Aggressive resection without compromising the patient\u2019s neurological status remains a significant challenge in treating intracranial gliomas. Our current study aims to evaluate the efficacy and safety of extra-operative stimulation and mapping via implanted subdural electrodes with or without depth (EOCSM), offering an alternative approach when awake mapping is contraindicated. Methods: Fifty-one patients undergoing EOCSM for glioma resection in our institution formed the sample study of our current retrospective study. We assessed the effectiveness and safety of our approach by measuring the extent of resection and recording the periprocedural complications, respectively. Results: The mean age of our participants was 58 years (\u00b19.4 years). The lesion was usually located on the left side (80.4%) and affected the frontal lobe (51.0%). EOCSM was successful in 94.1% of patients. The stimulation and electrode implantation procedures lasted for a median of 2.0 h and 75 h, respectively. Stimulation-induced seizures and CSF leakage occurred in 13.7% and 5.9% of our cases. The mean extent of resection was 91.6%, whereas transient dysphasia occurred in 21.6% and transient hemiparesis in 5.9% of our patients, respectively. Conclusions: Extraoperative stimulation and mapping constitute a valid alternative mapping option in glioma patients who cannot undergo an awake craniotomy.<\/jats:p>","DOI":"10.3390\/brainsci12111434","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T12:29:45Z","timestamp":1666700985000},"page":"1434","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of Extra-Operative Cortical Stimulation and Mapping in the Surgical Management of Intracranial Gliomas"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-3799","authenticated-orcid":false,"given":"Kostas N.","family":"Fountas","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Faculty of Medicine, University of Thessaly, 41200 Larisa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6031-4528","authenticated-orcid":false,"given":"Alexandros","family":"Brotis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General University Hospital of Larissa, 41200 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-6754","authenticated-orcid":false,"given":"Thanasis","family":"Paschalis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, General University Hospital of Larissa, 41200 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eftychia","family":"Kapsalaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, University of Thessaly, 41200 Larisa, Greece"},{"name":"Department of Neuroradiology, Institute Euromedica-Encephalos, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hervey-Jumper, S.L., and Berger, M.S. 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