{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T08:52:28Z","timestamp":1762073548003,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education"},{"name":"National Research Foundation of Korea"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>The human ventromedial prefrontal cortex (vmPFC) has been traditionally associated with decision-making under risk. Neuroimaging studies of such decision-making processes have largely focused on patients with vmPFC lesions or pathological gambling behavior, leading to a relative paucity of work focusing on the structural variability of the vmPFC in healthy individuals. To address this, we developed a decision-making task that allowed healthy players to choose to participate in either low stakes or high-stakes gambling on a trial-by-trial basis, and computed a metric that indexes the propensity for engaging in gambles with greater potential payoffs. We leveraged voxel-based morphometric analyses to examine the association between prefrontal gray matter volume and individual differences in the propensity for seeking high-risk\/high-reward situations. Our analyses showed that vmPFC gray matter volume was inversely correlated with an increased tendency for engaging in high-stakes gambling. These results converge with findings from functional neuroimaging and brain lesion studies of vmPFC, and further extend them to show that normative variability in brain structure could also underpin risk-taking behavior.<\/jats:p>","DOI":"10.3390\/brainsci12111460","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T23:45:00Z","timestamp":1667087100000},"page":"1460","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Volumetric Variability of the Ventromedial Prefrontal Cortex Reflects the Propensity for Engaging in High-Stakes Gambling Behavior"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6713-5389","authenticated-orcid":false,"given":"Kyuli","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Psychology, Sungkyunkwan University, Seoul 03063, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychology, Sungkyunkwan University, Seoul 03063, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Joo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Psychology, Sungkyunkwan University, Seoul 03063, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Suk","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Psychology, Sungkyunkwan University, Seoul 03063, Korea"},{"name":"Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Justin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychology, Sungkyunkwan University, Seoul 03063, Korea"},{"name":"Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.conb.2012.06.001","article-title":"The root of all value: A neural common currency for choice","volume":"22","author":"Levy","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1098\/rstb.2009.0147","article-title":"Decision-making during gambling: An integration of cognitive and psychobiological approaches","volume":"365","author":"Clark","year":"2010","journal-title":"Phil. Trans. R. Soc. 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