{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:59:09Z","timestamp":1780426749873,"version":"3.54.1"},"reference-count":57,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>This study aimed to determine whether dissociative symptoms and childhood trauma (CT) may help identify a specific subgroup of patients among those hospitalized for alcohol use disorder (AUD). We assessed 587 patients hospitalized for an AUD in a French addiction rehabilitation center (cross-sectional study) regarding dissociative symptoms (DES-taxon), childhood trauma (CTQ), depression (BDI), anxiety (STAI-state and STAI-trait), posttraumatic stress disorder (PTSD; PCL-5), and AUD symptoms (AUDIT). We ran a hierarchical cluster analysis and compared the clusters in terms of dissociation and CT, as well as AUD, depressive, anxiety, and PTSD symptoms. We identified three clusters of patients: (1) patients with low AUD severity and low dissociation (LALD); (2) patients with high AUD severity and low dissociation (HALD); (3) patients with high AUD severity and high dissociation (HAHD). Patients from the HAHD group had significantly higher dissociation and more severe depression, anxiety, and PTSD symptoms than those with LALD and HALD. They also reported more emotional and sexual abuse than those with LALD. Among patients with an AUD, those with high dissociation may constitute an independent subgroup that exhibits a higher prevalence for CT and higher AUD severity, as well as higher depression, anxiety, and PTSD symptoms. Patients with more severe AUD and associated psychiatric symptoms should be systematically screened for dissociation and provided with tailor-based treatments.<\/jats:p>","DOI":"10.3390\/brainsci12111483","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T06:49:02Z","timestamp":1667371742000},"page":"1483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Childhood Trauma and Dissociation Correlates in Alcohol Use Disorder: A Cross-Sectional Study in a Sample of 587 French Subjects Hospitalized in a Rehabilitation Center"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5285-5401","authenticated-orcid":false,"given":"Gr\u00e9goire","family":"Baudin","sequence":"first","affiliation":[{"name":"Laboratoire de Psychopathologie et Processus de Sant\u00e9, Universit\u00e9 Paris Cit\u00e9, F-92100 Boulogne Billancourt, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servane","family":"Barrault","sequence":"additional","affiliation":[{"name":"Laboratoire de Psychopathologie et Processus de Sant\u00e9, Universit\u00e9 Paris Cit\u00e9, F-92100 Boulogne Billancourt, France"},{"name":"QualiPsy, EE 1901, Universit\u00e9 de Tours, F-37000 Tours, France"},{"name":"CHRU de Tours, Service d\u2019Addictologie Universitaire, CSAPA-37, F-37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"El Ayoubi","sequence":"additional","affiliation":[{"name":"Clinique Ronsard, Ramsay Sant\u00e9, F-37170 Chambray-l\u00e8s-Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Kazour","sequence":"additional","affiliation":[{"name":"CHRU de Tours, Clinique Psychiatrique Universitaire, F-37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Ballon","sequence":"additional","affiliation":[{"name":"CHRU de Tours, Service d\u2019Addictologie Universitaire, Equipe de Liaison et de Soins en Addictologie, F-37000 Tours, France"},{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, F-37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Maug\u00e9","sequence":"additional","affiliation":[{"name":"CHRU de Tours, Service d\u2019Addictologie Universitaire, CSAPA-37, F-37000 Tours, France"},{"name":"CHRU de Tours, Service d\u2019Addictologie Universitaire, Equipe de Liaison et de Soins en Addictologie, F-37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coraline","family":"Hingray","sequence":"additional","affiliation":[{"name":"P\u00f4le Universitaire Adulte du Grand Nancy CPN, F-54520 Laxou, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9317-228X","authenticated-orcid":false,"given":"Paul","family":"Brunault","sequence":"additional","affiliation":[{"name":"QualiPsy, EE 1901, Universit\u00e9 de Tours, F-37000 Tours, France"},{"name":"CHRU de Tours, Service d\u2019Addictologie Universitaire, Equipe de Liaison et de Soins en Addictologie, F-37000 Tours, France"},{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, F-37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-0855","authenticated-orcid":false,"given":"Wissam","family":"El-Hage","sequence":"additional","affiliation":[{"name":"CHRU de Tours, Clinique Psychiatrique Universitaire, F-37000 Tours, France"},{"name":"UMR 1253, iBrain, Universit\u00e9 de Tours, Inserm, F-37000 Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jad.2003.12.013","article-title":"Adverse Childhood Experiences and the Risk of Depressive Disorders in Adulthood","volume":"82","author":"Chapman","year":"2004","journal-title":"J. Affect. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.eurpsy.2015.04.007","article-title":"The Role of Specific Early Trauma in Adult Depression: A Meta-Analysis of Published Literature. Childhood Trauma and Adult Depression","volume":"30","author":"Mandelli","year":"2015","journal-title":"Eur. Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/da.20238","article-title":"Childhood Emotional, Physical, and Sexual Abuse, and Diagnoses of Depressive and Anxiety Disorders in Adult Psychiatric Outpatients","volume":"24","author":"Gibb","year":"2007","journal-title":"Depress. Anxiety"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1001\/archpsyc.57.10.953","article-title":"Childhood Sexual Abuse and Adult Psychiatric and Substance Use Disorders in Women: An Epidemiological and Cotwin Control Analysis","volume":"57","author":"Kendler","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chiabu.2016.07.005","article-title":"Childhood Emotional Maltreatment and Mental Disorders: Results from a Nationally Representative Adult Sample from the United States","volume":"59","author":"Taillieu","year":"2016","journal-title":"Child Abus. Negl."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1017\/S0033291718000740","article-title":"Dissociation in Victims of Childhood Abuse or Neglect: A Meta-Analytic Review","volume":"48","author":"Vonderlin","year":"2018","journal-title":"Psychol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Konkol\u00ff Thege, B., Horwood, L., Slater, L., Tan, M.C., Hodgins, D.C., and Wild, T.C. (2017). Relationship between Interpersonal Trauma Exposure and Addictive Behaviors: A Systematic Review. BMC Psychiatry, 17.","DOI":"10.1186\/s12888-017-1323-1"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1176\/appi.ps.53.8.1001","article-title":"Adverse Childhood Experiences, Alcoholic Parents, and Later Risk of Alcoholism and Depression","volume":"53","author":"Anda","year":"2002","journal-title":"Psychiatr. Serv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.chiabu.2017.04.004","article-title":"Adverse Childhood Experiences, Mental Health, and Excessive Alcohol Use: Examination of Race\/Ethnicity and Sex Differences","volume":"69","author":"Lee","year":"2017","journal-title":"Child Abus. Negl."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Rehan, W., Antfolk, J., Johansson, A., Jern, P., and Santtila, P. (2017). Experiences of Severe Childhood Maltreatment, Depression, Anxiety and Alcohol Abuse among Adults in Finland. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0177252"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/acer.12990","article-title":"Profiles of Childhood Trauma in Patients with Alcohol Dependence and Their Associations with Addiction-Related Problems","volume":"40","author":"Lotzin","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/10826084.2017.1361997","article-title":"Traumatic Experiences, Revictimization and Posttraumatic Stress Disorder in German Inpatients Treated for Alcohol Dependence","volume":"53","author":"Grundmann","year":"2018","journal-title":"Subst. Use Misuse"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1530-0277.2010.01347.x","article-title":"Child Physical and Sexual Abuse: A Comprehensive Look at Alcohol Consumption Patterns, Consequences, and Dependence from the National Alcohol Survey","volume":"35","author":"Nayak","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.15288\/jsad.2007.68.317","article-title":"Long-Term Effects of Child Abuse and Neglect on Alcohol Use and Excessive Drinking in Middle Adulthood","volume":"68","author":"Widom","year":"2007","journal-title":"J. Stud. Alcohol Drugs"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.psychres.2007.10.016","article-title":"Social Anxiety and Dissociation among Male Patients with Alcohol Dependency","volume":"165","author":"Evren","year":"2009","journal-title":"Psychiatry Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/jts.20021","article-title":"Motives to Drink as Mediators between Childhood Sexual Assault and Alcohol Problems in Adult Women","volume":"18","author":"Grayson","year":"2005","journal-title":"J. Trauma. Stress"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1111\/acer.12419","article-title":"A Longitudinal Examination of Different Etiological Pathways to Alcohol Use and Misuse","volume":"38","author":"Mezquita","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ertl, V., Saile, R., Neuner, F., and Catani, C. (2016). Drinking to Ease the Burden: A Cross-Sectional Study on Trauma, Alcohol Abuse and Psychopathology in a Post-Conflict Context. BMC Psychiatry, 16.","DOI":"10.1186\/s12888-016-0905-7"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.psychres.2005.08.004","article-title":"Dissociative Disorders among Alcohol-Dependent Inpatients","volume":"152","author":"Evren","year":"2007","journal-title":"Psychiatry Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.drugalcdep.2009.12.012","article-title":"Childhood Trauma and Dissociation in Patients with Alcohol Dependence, Drug Dependence, or Both\u2014A Multi-Center Study","volume":"109","author":"Langeland","year":"2010","journal-title":"Drug Alcohol Depend."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.comppsych.2007.05.013","article-title":"Dissociative Symptoms in Alcohol-Dependent Patients: Associations with Childhood Trauma and Substance Abuse Characteristics","volume":"48","author":"Reininghaus","year":"2007","journal-title":"Compr. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/10550887.2016.1139428","article-title":"Proposed Pathways to Problematic Drinking via Post-Traumatic Stress Disorder Symptoms, Emotion Dysregulation, and Dissociative Tendencies Following Child\/Adolescent Sexual Abuse","volume":"35","author":"Klanecky","year":"2016","journal-title":"J. Addict. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0740-5472(93)90057-9","article-title":"Chemical Dissociation in Adults Sexually Victimized as Children: Alcohol and Drug Use in Adult Survivors","volume":"10","author":"Roesler","year":"1993","journal-title":"J. Subst. Abus. Treat."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.comppsych.2009.09.007","article-title":"Dissociative Psychopathology among Opioid Use Disorder Patients: Exploring the \u201cChemical Dissociation\u201d Hypothesis","volume":"51","author":"Somer","year":"2010","journal-title":"Compr. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejtd.2018.02.001","article-title":"Impact of Trauma on Addiction and Psychopathology Profile in Alcohol-Dependent Women","volume":"2","author":"Hingray","year":"2018","journal-title":"Eur. J. Trauma Dissociation"},{"key":"ref_27","unstructured":"World Health Organization (2016). International Statistical Classification of Diseases and Related Health Problems, WHO. [10th ed.]. Available online: https:\/\/icd.who.int\/browse10\/2016\/en."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0145-2134(02)00541-0","article-title":"Development and Validation of a Brief Screening Version of the Childhood Trauma Questionnaire","volume":"27","author":"Bernstein","year":"2003","journal-title":"Child Abus. Negl."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.7202\/008831ar","article-title":"Validation de la version fran\u00e7aise du CTQ et pr\u00e9valence de l\u2019histoire de maltraitance","volume":"29","author":"Paquette","year":"2004","journal-title":"St. Ment. Au Qu\u00e9bec"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1176\/ajp.150.7.1030","article-title":"Validity of the Dissociative Experiences Scale in Screening for Multiple Personality Disorder: A Multicenter Study","volume":"150","author":"Carlson","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/070674379904400308","article-title":"Validation of a French Version of the Dissociative Experiences Scale in a Rape-Victim Population","volume":"44","author":"Degiovanni","year":"1999","journal-title":"Can. J. Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1037\/1082-989X.1.3.300","article-title":"Types of Dissociation and Dissociative Types: A Taxometric Analysis of Dissociative Experiences","volume":"1","author":"Waller","year":"1996","journal-title":"Psychol. Methods"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1037\/0021-843X.106.4.499","article-title":"The Prevalence and Biometric Structure of Pathological Dissociation in the General Population: Taxometric and Behavior Genetic Findings","volume":"106","author":"Waller","year":"1997","journal-title":"J. Abnorm. Psychol."},{"key":"ref_34","unstructured":"World Health Organization (2021, March 16). AUDIT: The Alcohol Use Disorders Identification Test: Guidelines for Use in Primary Health Care (WHO\/MSD\/MSB\/01.6a). Available online: https:\/\/www.who.int\/publications\/i\/item\/WHO-MSD-MSB-01.6a."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1097\/01.alc.0000187034.58955.64","article-title":"The Alcohol Use Disorders Identification Test (AUDIT) as a Screening Tool for Excessive Drinking in Primary Care: Reliability and Validity of a French Version","volume":"29","author":"Gache","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of Beck Depression Inventories -IA and -II in Psychiatric Outpatients","volume":"67","author":"Beck","year":"1996","journal-title":"J. Pers. Assess."},{"key":"ref_37","first-page":"77","article-title":"The Shortened Beck Depression Inventory (13 Items). Study of the Concurrent Validity with the Hamilton Scale and Widl\u00f6cher\u2019s Retardation Scale","volume":"12","author":"Collet","year":"1986","journal-title":"L\u2019Enc\u00e9phale"},{"key":"ref_38","unstructured":"Spielberger, C., Gorsuch, R., Lushene, R., Vagg, P., and Jacobs, G. (1983). Manual for the State-Trait Anxiety Inventory (Form Y1\u2013Y2), Consulting Psychologists Press."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1037\/h0078881","article-title":"A French-Canadian Adaptation of the Revised Version of Spielberger\u2019s State-Trait Anxiety Inventory","volume":"25","author":"Gauthier","year":"1993","journal-title":"Can. J. Behav. Sci.\/Rev. Can. Sci. Comport."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jts.22059","article-title":"The Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5): Development and Initial Psychometric Evaluation","volume":"28","author":"Blevins","year":"2015","journal-title":"J. Trauma. Stress"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ashbaugh, A.R., Houle-Johnson, S., Herbert, C., El-Hage, W., and Brunet, A. (2016). Psychometric Validation of the English and French Versions of the Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5). PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161645"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_43","unstructured":"R Core Team (2021, March 16). R: A Language and Environment for Statistical Computing. Available online: https:\/\/cran.r-project.org\/manuals.html."},{"key":"ref_44","unstructured":"Kassambara, A. (2017). HCPC: Hierarchical Clustering on Principal Components. Practical Guide to Principal Component Methods in R, CreateSpace Independent Publishing Platform."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v070.i01","article-title":"MissMDA: A Package for Handling Missing Values in Multivariate Data Analysis","volume":"70","author":"Josse","year":"2016","journal-title":"J. Stat. Softw."},{"key":"ref_46","first-page":"1","article-title":"FactoMineR: An R Package for Multivariate Analysis","volume":"25","author":"Josse","year":"2008","journal-title":"J. Stat. Softw."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.chiabu.2017.03.016","article-title":"Unpacking the Impact of Adverse Childhood Experiences on Adult Mental Health","volume":"69","author":"Merrick","year":"2017","journal-title":"Child Abus. Negl."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/15504263.2019.1620398","article-title":"Changes of Self-Reported PTSD and Depression Symptoms During Alcohol Detoxification Treatment","volume":"15","author":"Ostergaard","year":"2019","journal-title":"J. Dual Diagn."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/acer.13292","article-title":"Gender Differences in Affects and Craving in Alcohol-Dependence: A Study During Alcohol Detoxification","volume":"41","author":"Petit","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/da.22024","article-title":"Reports of Drinking to Self-Medicate Anxiety Symptoms: Longitudinal Assessment for Subgroups of Individuals with Alcohol Dependence","volume":"30","author":"Crum","year":"2013","journal-title":"Depress. Anxiety"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1001\/jamapsychiatry.2013.1098","article-title":"A Prospective Assessment of Reports of Drinking to Self-Medicate Mood Symptoms with the Incidence and Persistence of Alcohol Dependence","volume":"70","author":"Crum","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4088\/JCP.v66n1007","article-title":"Dissociative Disorders among Inpatients with Drug or Alcohol Dependency","volume":"66","author":"Karadag","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/alcalc\/36.3.249","article-title":"The Course of Anxiety, Depression and Drinking Behaviours after Completed Detoxification in Alcoholics with and without Comorbid Anxiety and Depressive Disorders","volume":"36","author":"Driessen","year":"2001","journal-title":"Alcohol Alcohol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/j.1360-0443.2012.03860.x","article-title":"Predictors of the 2-Year Recurrence and Persistence of Alcohol Dependence","volume":"107","author":"Boschloo","year":"2012","journal-title":"Addiction"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamapsychiatry.2019.0097","article-title":"Agreement Between Prospective and Retrospective Measures of Childhood Maltreatment: A Systematic Review and Meta-Analysis","volume":"76","author":"Baldwin","year":"2019","journal-title":"JAMA Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.alcohol.2005.12.002","article-title":"Treated and Treatment-Naive Alcoholics Come from Different Populations","volume":"36","author":"Fein","year":"2005","journal-title":"Alcohol"},{"key":"ref_57","first-page":"1","article-title":"Psychological Therapies for Post-traumatic Stress Disorder and Comorbid Substance Use Disorder","volume":"4","author":"Roberts","year":"2016","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/11\/1483\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:07:19Z","timestamp":1760144839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/12\/11\/1483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":57,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["brainsci12111483"],"URL":"https:\/\/doi.org\/10.3390\/brainsci12111483","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,1]]}}}