{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:06:36Z","timestamp":1762074396946,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"NSFC","doi-asserted-by":"publisher","award":["82101424"],"award-info":[{"award-number":["82101424"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Background: The diagnosis of hydrocephalus is mainly based on imaging findings. However, the significance of many imaging indicators may change, especially in some degenerative diseases, and even lead to misdiagnosis. Methods: This study explored the effectiveness of commonly used morphological parameters and typical radiographic findings in hydrocephalus diagnosis. The patients\u2019 imaging data were divided into three groups, including the hydrocephalus group, the symptomatic group, and the normal control group. The diagnostic validity and weight of various parameters were compared between groups by multiple machine learning methods. Results: Our results demonstrated that Evans\u2019 ratio is the most valuable diagnostic indicator compared to the hydrocephalus group and the normal control group. But frontal horns\u2019 ratio is more useful in diagnosing patients with symptoms. Meanwhile, the sign of disproportionately enlarged subarachnoid space and third ventricle enlargement could be effective diagnostic indicators in all situations. Conclusion: Both morphometric parameters and radiological features were essential in diagnosing hydrocephalus, but the weights are different in different situations. The machine learning approaches can be applied to optimize the diagnosis of other diseases and consistently update the clinical diagnostic criteria.<\/jats:p>","DOI":"10.3390\/brainsci12111484","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T06:49:02Z","timestamp":1667371742000},"page":"1484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multiple Machine Learning Approaches for Morphometric Parameters in Prediction of Hydrocephalus"],"prefix":"10.3390","volume":"12","author":[{"given":"Hao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejun","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoshi","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0140-6736(15)60694-8","article-title":"Hydrocephalus in children","volume":"387","author":"Kahle","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3171\/2012.3.PEDS0934","article-title":"Theories of cerebrospinal fluid dynamics and hydrocephalus: Historical trend","volume":"11","author":"Symss","year":"2013","journal-title":"J. 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