{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:25:28Z","timestamp":1772252728896,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian Research Council Future Fellowship"},{"name":"National Health and Medical Research Council (NHMRC) of Australia"},{"name":"Australian Postgraduate Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Dysregulation of high-frequency neuronal oscillations has been implicated in the pathophysiology of schizophrenia. Chronic methamphetamine (METH) use can induce psychosis similar to paranoid schizophrenia. The current study in mice aimed to determine the effect of chronic METH treatment on ongoing and evoked neuronal oscillations. C57BL\/6 mice were treated with METH or vehicle control for three weeks and implanted with extradural recording electrodes. Two weeks after the last METH injection, mice underwent three EEG recording sessions to measure ongoing and auditory-evoked gamma and beta oscillatory power in response to an acute challenge with METH (2 mg\/kg), the NMDA receptor antagonist MK-801 (0.3 mg\/kg), or saline control. A separate group of mice pretreated with METH showed significantly greater locomotor hyperactivity to an acute METH challenge, confirming long-term sensitisation. Chronic METH did not affect ongoing or evoked gamma or beta power. Acute MK-801 challenge reduced ongoing beta power whereas acute METH challenge significantly increased ongoing gamma power. Both MK-801 and METH challenge suppressed evoked gamma power. Chronic METH treatment did not modulate these acute drug effects. There were minor effects of chronic METH and acute METH and MK-801 on selected components of event-related potential (ERP) waves. In conclusion, chronic METH treatment did not exert neuroplastic effects on the regulation of cortical gamma oscillations in a manner consistent with schizophrenia, despite causing behavioural sensitisation.<\/jats:p>","DOI":"10.3390\/brainsci12111503","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T02:43:51Z","timestamp":1667789031000},"page":"1503","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential Effects of Chronic Methamphetamine Treatment on High-Frequency Oscillations and Responses to Acute Methamphetamine and NMDA Receptor Blockade in Conscious Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Matthew R.","family":"Hudson","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3052, Australia"},{"name":"Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Foreman","sequence":"additional","affiliation":[{"name":"Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia"},{"name":"Centre for Eye Research Australia, Ophthalmology Eye and Ear Hospital, Melbourne, VIC 3002, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Rind","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth E.","family":"Manning","sequence":"additional","affiliation":[{"name":"Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia"},{"name":"School of Biomedical Science and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-8439","authenticated-orcid":false,"given":"Nigel C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC 3052, Australia"},{"name":"Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia"},{"name":"Department of Neurology, The Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7555-3799","authenticated-orcid":false,"given":"Maarten","family":"van den Buuse","sequence":"additional","affiliation":[{"name":"Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3052, Australia"},{"name":"School of Psychology and Public Health, La Trobe University, Melbourne, VIC 3086, Australia"},{"name":"Department of Pharmacology, University of Melbourne, Melbourne, VIC 3052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11065-007-9031-0","article-title":"Neurocognitive effects of methamphetamine: A critical review and meta-analysis","volume":"17","author":"Scott","year":"2007","journal-title":"Neuropsychol. 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