{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:36:32Z","timestamp":1778690192289,"version":"3.51.4"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Province Drug Rehabilitation Administration","award":["XLZT-19FFC040002"],"award-info":[{"award-number":["XLZT-19FFC040002"]}]},{"name":"Sichuan Province Drug Rehabilitation Administration","award":["21XJA890001"],"award-info":[{"award-number":["21XJA890001"]}]},{"name":"Sichuan Province Drug Rehabilitation Administration","award":["21ZDYF062"],"award-info":[{"award-number":["21ZDYF062"]}]},{"name":"Sichuan Province Drug Rehabilitation Administration","award":["2022-A058"],"award-info":[{"award-number":["2022-A058"]}]},{"name":"Humanities and Social Sciences Project of the Ministry of Education","award":["XLZT-19FFC040002"],"award-info":[{"award-number":["XLZT-19FFC040002"]}]},{"name":"Humanities and Social Sciences Project of the Ministry of Education","award":["21XJA890001"],"award-info":[{"award-number":["21XJA890001"]}]},{"name":"Humanities and Social Sciences Project of the Ministry of Education","award":["21ZDYF062"],"award-info":[{"award-number":["21ZDYF062"]}]},{"name":"Humanities and Social Sciences Project of the Ministry of Education","award":["2022-A058"],"award-info":[{"award-number":["2022-A058"]}]},{"name":"Major project of Sichuan Science and Technology Department","award":["XLZT-19FFC040002"],"award-info":[{"award-number":["XLZT-19FFC040002"]}]},{"name":"Major project of Sichuan Science and Technology Department","award":["21XJA890001"],"award-info":[{"award-number":["21XJA890001"]}]},{"name":"Major project of Sichuan Science and Technology Department","award":["21ZDYF062"],"award-info":[{"award-number":["21ZDYF062"]}]},{"name":"Major project of Sichuan Science and Technology Department","award":["2022-A058"],"award-info":[{"award-number":["2022-A058"]}]},{"name":"Sports Medicine Key Laboratory of Sichuan Province","award":["XLZT-19FFC040002"],"award-info":[{"award-number":["XLZT-19FFC040002"]}]},{"name":"Sports Medicine Key Laboratory of Sichuan Province","award":["21XJA890001"],"award-info":[{"award-number":["21XJA890001"]}]},{"name":"Sports Medicine Key Laboratory of Sichuan Province","award":["21ZDYF062"],"award-info":[{"award-number":["21ZDYF062"]}]},{"name":"Sports Medicine Key Laboratory of Sichuan Province","award":["2022-A058"],"award-info":[{"award-number":["2022-A058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Objective: Drug dependence has become a major global public health problem. This study aimed to investigate the effects of moderate-intensity aerobic exercise on the blood\u2013brain barrier and neurological damage in methamphetamine (MA)-dependent individuals. Methods: MA-dependent individuals (all males) were recruited and randomly divided into MA exercise group (MAE) and MA control group (MAC) by using random number table method. The MAE group underwent 12 weeks of moderate-intensity aerobic exercise, and the MAC group underwent conventional detoxification. The Neurofilament light chain (NfL), S100 calcium binding protein b (S100b), and Neuron-Specific Enolase (NSE) levels in the blood of MA-dependent individuals were measured before and after the exercise intervention. Results: After the exercise intervention was implemented, the amount of change in NfL in the plasma of the MAE (1.75 \u00b1 1.40) group was significantly different from that of the MAC (0.60 \u00b1 1.21) group (p &lt; 0.01); the amount of change in NSE in the serum of the MAE [\u22121.51 (\u22123.99~0.31)] group was significantly different from that of the MAC [0.03 (\u22121.18~1.16)] group (p &lt; 0.05); and the amount of change in S100b in the serum of the MAE [0.66 (0.40~0.95)] group was not significantly different from that of the MAC (0.60 (0.21~1.04)) group (p &gt; 0.05). Conclusion: This study showed that 12 weeks of moderate-intensity aerobic exercise treatment significantly promoted the recovery of blood\u2013brain barrier and neurological damage in MA-dependent patients compared with conventional withdrawal.<\/jats:p>","DOI":"10.3390\/brainsci12111521","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:01:45Z","timestamp":1668045705000},"page":"1521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Aerobic Exercise on Markers of Brain Injury in Methamphetamine-Dependent Individuals: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"12","author":[{"given":"Zhicheng","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jisheng","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan Ziyang Compulsory Isolation Detoxification Institute, Ziyang 641300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4988-4495","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"School of Sports Medicine and Health, Chengdu Sport University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"ref_1","unstructured":"UNODC (2022, July 01). 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