{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:57:08Z","timestamp":1792789028625,"version":"4.5.0"},"reference-count":124,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100604"],"award-info":[{"award-number":["82100604"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021-YF05-01576-SN"],"award-info":[{"award-number":["2021-YF05-01576-SN"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Innovation Project of Key R&amp;D Support Plans of Chengdu Science and Technology Municipality","award":["82100604"],"award-info":[{"award-number":["82100604"]}]},{"name":"Technology Innovation Project of Key R&amp;D Support Plans of Chengdu Science and Technology Municipality","award":["2021-YF05-01576-SN"],"award-info":[{"award-number":["2021-YF05-01576-SN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Cerebral ischemia impedes the functional or metabolic demands of the central nervous system (CNS), which subsequently leads to irreversible brain damage. While recanalization of blocked vessels recovers cerebral blood flow, it can also aggravate brain injury, termed as ischemia\/reperfusion (I\/R) injury. Exosomes, nanometric membrane vesicles, attracted wide attention as carriers of biological macromolecules. In the brain, exosomes can be secreted by almost all types of cells, and their contents can be altered during the pathological and clinical processes of cerebral I\/R injury. Herein, we will review the current literature on the possible role of cargos derived from exosomes and exosomes-mediated intercellular communication in cerebral I\/R injury. The PubMed and Web of Science databases were searched through January 2015. The studies published in English were identified using search terms including \u201cexosomes\u201d, \u201ccerebral ischemia-reperfusion injury\u201d, \u201cbrain ischemia-reperfusion injury\u201d, and \u201cstroke\u201d. We will also focus on the potential therapeutic effects of stem cell-derived exosomes and underlying mechanisms in cerebral I\/R injury. Meanwhile, with the advantages of low immunogenicity and cytotoxicity, high bioavailability, and the capacity to pass through the blood\u2013brain barrier, exosomes also attract more attention as therapeutic modalities for the treatment of cerebral I\/R injury.<\/jats:p>","DOI":"10.3390\/brainsci12121657","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T02:56:26Z","timestamp":1670208986000},"page":"1657","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exosomes in Cerebral Ischemia-Reperfusion Injury: Current Perspectives and Future Challenges"],"prefix":"10.3390","volume":"12","author":[{"given":"Chao","family":"Zhou","sequence":"first","affiliation":[{"name":"Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu 610041, China"},{"name":"Disaster Medical Center, Sichuan University, Chengdu 610041, China"},{"name":"Department of Emergency Medicine, Chengdu First People\u2019s Hospital, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fating","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu 610041, China"},{"name":"Disaster Medical Center, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yarong","family":"He","sequence":"additional","affiliation":[{"name":"Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu 610041, China"},{"name":"Disaster Medical Center, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Fifth People\u2019s Hospital of Chengdu, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cao","sequence":"additional","affiliation":[{"name":"Laboratory of Emergency Medicine, Department of Emergency Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu 610041, China"},{"name":"Disaster Medical Center, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e923","DOI":"10.1161\/CIR.0000000000000968","article-title":"Perioperative Neurological Evaluation and Management to Lower the Risk of Acute Stroke in Patients Undergoing Noncardiac, Nonneurological Surgery: A Scientific Statement From the American Heart Association\/American Stroke Association","volume":"143","author":"Benesch","year":"2021","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"828447","DOI":"10.3389\/fimmu.2022.828447","article-title":"Interleukins and Ischemic Stroke","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. 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