{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:46:04Z","timestamp":1776329164633,"version":"3.50.1"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T00:00:00Z","timestamp":1671235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&amp;D Program of China","award":["2021YFC2501200"],"award-info":[{"award-number":["2021YFC2501200"]}]},{"name":"National Key R&amp;D Program of China","award":["2017ZX09304018"],"award-info":[{"award-number":["2017ZX09304018"]}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2021YFC2501200"],"award-info":[{"award-number":["2021YFC2501200"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2017ZX09304018"],"award-info":[{"award-number":["2017ZX09304018"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Introduction: Fatigue is one of the most common and disabling symptoms of Parkinson\u2019s Disease (PD). The occurrence and clinical features of fatigue in patients with prodromal PD remain largely elusive. This study aimed to investigate the prevalence and clinical characteristics of fatigue in patients with idiopathic\/isolated REM sleep behavior disorders (iRBD). Methods: A total of 97 polysomnography-confirmed iRBD patients were enrolled in this study. A comprehensive neurological assessment (including motor and non-motor assessment) was performed. Fatigue was assessed using the Fatigue Severity Scale (FSS). Motor and non-motor characteristics were compared between iRBD patients with and without fatigue. Logistic regression was used to identify the factors associated with fatigue. Results: The prevalence of fatigue was 35.05%. Compared to the non-fatigue patients, patients with fatigue had higher non-motor symptom scale (NMSS) score (p = 0.009), higher Hamilton Depression Rating Scale (HAMD) score (p = 0.002), and a higher prevalence of orthostatic hypotension (p = 0.021). Multivariate regression analysis showed that depression (OR 4.17, 95% CI 1.13\u201315.49, p = 0.033) and orthostatic hypotension (OR 2.80, 95% CI 1.09\u20137.18, p = 0.032) were significantly associated with fatigue in iRBD patients. Additionally, both NMSS (rs = 0.310, p = 0.002) and HAMD (rs = 0.385, p &lt; 0.001) scores were mildly correlated with fatigue severity. Conclusion: Our study showed that fatigue is common in patients with iRBD. In addition, depression and orthostatic hypotension were independently associated with fatigue in iRBD patients.<\/jats:p>","DOI":"10.3390\/brainsci12121728","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T05:55:43Z","timestamp":1671429343000},"page":"1728","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fatigue in Patients with Idiopathic\/Isolated REM Sleep Behavior Disorder"],"prefix":"10.3390","volume":"12","author":[{"given":"Yajie","family":"Zang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"},{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"},{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanning","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"},{"name":"Department of Biobank, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagadish K.","family":"Chhetri","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piu","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"},{"name":"Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"},{"name":"Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.pmrj.2010.04.003","article-title":"The genetics and epigenetics of fatigue","volume":"2","author":"Reinertsen","year":"2010","journal-title":"PM&R"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1212\/WNL.0b013e31827f07be","article-title":"Fatigue and fatigability in neurologic illnesses: Proposal for a unified taxonomy","volume":"80","author":"Kluger","year":"2013","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15025","DOI":"10.1038\/npjparkd.2015.25","article-title":"Fatigue in Parkinson\u2019s disease: Report from a mutidisciplinary symposium","volume":"2","author":"Friedman","year":"2016","journal-title":"NPJ Park. 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