{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:54:38Z","timestamp":1784321678183,"version":"3.55.0"},"reference-count":12,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>We would like to congratulate Sachdeva and colleagues for establishing an informative review regarding the effects of music\/sound exposure on blood\u2013brain barrier permeability and meningeal lymphatic\/glymphatic clearance, and would appreciate the opportunity to make a comment. The review by Sachdeva and colleagues documents the beneficial effects of sound interventions on blood\u2013brain barrier permeability and the activity of the meningeal lymphatic\/glymphatic system. The authors further note that sound interventions may have the potential to reduce the accumulation of amyloid-\u03b2 within the brain in Alzheimer\u2019s disease through improved meningeal lymphatic\/glymphatic clearance. The authors also nicely discuss evidence that music influences sleep quality, which may facilitate glymphatic solute clearance as a result of an increase in the interstitial space, which results in reduced resistance to fluid transport. We fully agree with this notion, since we recently hypothesized that immersive sound therapy may be an innovative approach to reduce the individual risk of developing neurodegenerative diseases, such as Alzheimer\u2019s disease, by inducing EEG slow-wave delta oscillations (which characterize deep sleep), thereby promoting glymphatic clearance.<\/jats:p>","DOI":"10.3390\/brainsci13010098","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T05:02:30Z","timestamp":1672808550000},"page":"98","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Can Immersive Sound Therapy Counteract Neurodegeneration by Enhancing Glymphatic Clearance? Comment on Sachdeva et al. Effects of Sound Interventions on the Permeability of the Blood\u2013Brain Barrier and Meningeal Lymphatic Clearance. Brain Sci. 2022, 12, 742"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7726-9751","authenticated-orcid":false,"given":"Peter","family":"Wostyn","sequence":"first","affiliation":[{"name":"Department of Psychiatry, PC Sint-Amandus, 8730 Beernem, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Goddaer","sequence":"additional","affiliation":[{"name":"Studio Ozark Henry, 8670 Wulpen, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sachdeva, S., Persaud, S., Patel, M., Popard, P., Colverson, A., and Dor\u00e9, S. (2022). Effects of sound interventions on the permeability of the blood-brain barrier and meningeal lymphatic clearance. Brain Sci., 12.","DOI":"10.3390\/brainsci12060742"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.37349\/ent.2022.00022","article-title":"Can meditation-based approaches improve the cleansing power of the glymphatic system?","volume":"2","author":"Wostyn","year":"2022","journal-title":"Explor. Neuroprot. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic System: A Beginner\u2019s Guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ana.24271","article-title":"Impairment of paravascular clearance pathways in the aging brain","volume":"76","author":"Kress","year":"2014","journal-title":"Ann. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.nbd.2016.05.015","article-title":"Suppression of glymphatic fluid transport in a mouse model of Alzheimer\u2019s disease","volume":"93","author":"Peng","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11604-017-0617-z","article-title":"Evaluation of glymphatic system activity with the diffusion MR technique: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer\u2019s disease cases","volume":"35","author":"Taoka","year":"2017","journal-title":"Jpn. J. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cophys.2019.10.020","article-title":"Cleaning the sleeping brain\u2014The potential restorative function of the glymphatic system","volume":"15","author":"Hauglund","year":"2020","journal-title":"Curr. Opin. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"ref_10","first-page":"172","article-title":"Deactivation of the medial prefrontal cortex in experienced Zen meditators. Abstract","volume":"20","author":"Faber","year":"2008","journal-title":"Brain Topogr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s10548-009-0107-4","article-title":"Meditators and non-meditators: EEG source imaging during resting","volume":"22","author":"Tei","year":"2009","journal-title":"Brain Topogr."},{"key":"ref_12","first-page":"101","article-title":"The impact of music on the bioelectrical oscillations of the brain","volume":"25","year":"2018","journal-title":"Acta Med. Litu."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/1\/98\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:58:20Z","timestamp":1760119100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/1\/98"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["brainsci13010098"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13010098","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]}}}