{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:16:02Z","timestamp":1787908562332,"version":"build-2784847793"},"reference-count":49,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Interdisciplinary Centre for Clinical Research","award":["TN1-6\/IA 532006"],"award-info":[{"award-number":["TN1-6\/IA 532006"]}]},{"name":"Interdisciplinary Centre for Clinical Research","award":["TN1-9\/IA 532009"],"award-info":[{"award-number":["TN1-9\/IA 532009"]}]},{"name":"Interdisciplinary Centre for Clinical Research","award":["DO 2386\/1-1"],"award-info":[{"award-number":["DO 2386\/1-1"]}]},{"name":"Interdisciplinary Centre for Clinical Research","award":["13GW0334B"],"award-info":[{"award-number":["13GW0334B"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["TN1-6\/IA 532006"],"award-info":[{"award-number":["TN1-6\/IA 532006"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["TN1-9\/IA 532009"],"award-info":[{"award-number":["TN1-9\/IA 532009"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["DO 2386\/1-1"],"award-info":[{"award-number":["DO 2386\/1-1"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["13GW0334B"],"award-info":[{"award-number":["13GW0334B"]}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["TN1-6\/IA 532006"],"award-info":[{"award-number":["TN1-6\/IA 532006"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["TN1-9\/IA 532009"],"award-info":[{"award-number":["TN1-9\/IA 532009"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["DO 2386\/1-1"],"award-info":[{"award-number":["DO 2386\/1-1"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["13GW0334B"],"award-info":[{"award-number":["13GW0334B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Myopathies fall under the umbrella of rare diseases, however, muscle pain is a relevant, under-recognized symptom with limited treatment options. Carbamazepine is an oral sodium channel blocker approved for the treatment of seizures and neuropathic pain. In 54 individuals receiving carbamazepine for muscle pain, we retrospectively assessed the subjective treatment response, side effects, and reasons for carbamazepine discontinuation. The underlying diagnoses leading to muscle pain were diverse, ranging from metabolic (n = 5) and other hereditary (n = 9) to acquired (n = 2) myopathies and myotonia syndromes (n = 22). Under carbamazepine (daily dose 254 \u00b1 138 mg), patients reported a significant reduction of pain, quantified by an 11-point numeric rating scale (\u22121.9 \u00b1 1.8, p &lt; 0.001). Compared to age- and sex-matched controls, our sensory assessment revealed a significant dysfunction of A\u03b4-nerve fibers in patients with chronic muscle pain. Neuropathic pain components identified by the painDETECT questionnaire or quantitative sensory testing did not seem to influence the reported treatment response. Side effects (n = 18) such as fatigue, elevated liver enzymes, and diarrhea, as well as lack of pain improvement (n = 6), led to carbamazepine discontinuation in 44.4% (24\/54). Mediated by dysfunctional A\u03b4-nerve fibers, muscle pain is common in a variety of myopathies. Carbamazepine may reduce pain levels, but comes with therapy-limiting side effects.<\/jats:p>","DOI":"10.3390\/brainsci13010123","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T01:33:12Z","timestamp":1673400792000},"page":"123","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Carbamazepine for Chronic Muscle Pain: A Retrospective Assessment of Indications, Side Effects, and Treatment Response"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2784-4225","authenticated-orcid":false,"given":"Tabea M.","family":"Dyong","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Gess","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Dumke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Rolke","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-9807","authenticated-orcid":false,"given":"Maike F.","family":"Dohrn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany"},{"name":"Dr. John T. Macdonald Foundation, Department of Human Genetics, John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF01212087","article-title":"Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol): Double blind crossover trial","volume":"5","author":"Rull","year":"1969","journal-title":"Diabetologia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(62)91847-0","article-title":"Trigeminal neuralgia: Its treatment with a new anticonvulsant drug (G-32883)","volume":"1","author":"Blom","year":"1962","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/pgmj.57.663.16","article-title":"Long-term treatment of trigeminal neuralgia with carbamazepine","volume":"57","author":"Taylor","year":"1981","journal-title":"Postgrad. 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