{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:46:00Z","timestamp":1782539160217,"version":"3.54.5"},"reference-count":71,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Second Hospital of Anhui Medical University","award":["2020LCYB16"],"award-info":[{"award-number":["2020LCYB16"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>This study aimed to assess the effect of the altered strength of the sound limb on the hemodynamics in the affected brain of stroke patients. We recruited 20 stroke patients to detect changes in the HbO concentrations in the bilateral prefrontal cortex (PFC), sensorimotor cortex (SMC), and occipital lobe (OL). We performed functional near-infrared spectroscopy (fNIRS) to detect changes in oxyhemoglobin (HbO) concentrations in regions of interest (ROIs) in the bilateral cerebral hemispheres of stroke patients while they performed 20%, 50%, and 80% maximal voluntary contraction (MVC) levels of handgrip tasks with the unaffected hands. The results suggest that when patients performed handgrip tasks with 50% of the MVC force, SMC in the affected cerebral hemisphere was strongly activated and the change in the HbO concentration was similar to that of the handgrip with 80% of MVC. When the force was 50% of MVC, the SMC in the affected hemisphere showed a more proportional activation than that at 80% MVC. Overall, this research suggests that stroke patients with a poor upper limb function should perform motor training with their sound hands at 50% of the MVC grip task to activate the ipsilesional hemisphere.<\/jats:p>","DOI":"10.3390\/brainsci13010141","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T01:31:15Z","timestamp":1673832675000},"page":"141","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cerebral Hemodynamic Changes during Unaffected Handgrip Exercises in Stroke Patients: An fNIRS Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Yuqin","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei 230601, China"},{"name":"Department of Rehabilitation Medicine, Second Clinical Medical College, Anhui Medical University, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei 230601, China"},{"name":"Department of Rehabilitation Medicine, Second Clinical Medical College, Anhui Medical University, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0750-1487","authenticated-orcid":false,"given":"Wen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei 230601, China"},{"name":"Department of Rehabilitation Medicine, Second Clinical Medical College, Anhui Medical University, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei 230601, China"},{"name":"Department of Rehabilitation Medicine, Second Clinical Medical College, Anhui Medical University, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-1344","authenticated-orcid":false,"given":"Xianshan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei 230601, China"},{"name":"Department of Rehabilitation Medicine, Second Clinical Medical College, Anhui Medical University, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/jcbfm.2008.101","article-title":"Reprint: Good laboratory practice: Preventing introduction of bias at the bench","volume":"29","author":"Macleod","year":"2009","journal-title":"J. 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