{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:00:55Z","timestamp":1791655255590,"version":"4.3.4"},"reference-count":100,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Drug Policies Department, Presidency of the Council of Ministers, Italy","award":["Effects of NPS: development of a multicentric research for the information enhancement of the Early Warning System"],"award-info":[{"award-number":["Effects of NPS: development of a multicentric research for the information enhancement of the Early Warning System"]}]},{"name":"Drug Policies Department, Presidency of the Council of Ministers, Italy","award":["FAR 2020 and FAR 2021 to M.M."],"award-info":[{"award-number":["FAR 2020 and FAR 2021 to M.M."]}]},{"name":"University of Ferrara","award":["Effects of NPS: development of a multicentric research for the information enhancement of the Early Warning System"],"award-info":[{"award-number":["Effects of NPS: development of a multicentric research for the information enhancement of the Early Warning System"]}]},{"name":"University of Ferrara","award":["FAR 2020 and FAR 2021 to M.M."],"award-info":[{"award-number":["FAR 2020 and FAR 2021 to M.M."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Over the last year, NPSs have been steadily on the rise in the illicit drug market. Among these, synthetic cathinones seem to become increasingly popular among young adults, mainly because of their ability to replicate the effects of traditional psychostimulant drugs, such as cocaine, MDMA and amphetamines. However, scarce data are available about the in vivo pharmaco-toxicology of these new substances. To this end, this study focused on evaluation of effects induced by repeated administration of mephtetramine (MTTA 0.1\u201330 mg\/kg i.p.) in mice. This atypical cathinone highlighted a sensorial (inhibition of visual and acoustic reflexes) and transient physiological parameter (decrease in breath rate and temperature) change in mice. Regarding motor activity, both a dose-dependent increase (accelerod test) and biphasic effect (drag and mobility time test) have been shown. In addition, blood and urine samples have been analysed to enrich the experimental featuring of the present study with reference to evaluation of potential toxicity related to consumption of MTTA. The latter analysis has particularly revealed important changes in blood cells count and blood and urine physicochemical profile after repeated treatment with this atypical cathinone. Moreover, MTTA induced histological changes in heart, kidney and liver samples, emphasizing its potential toxicity.<\/jats:p>","DOI":"10.3390\/brainsci13020161","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T02:04:35Z","timestamp":1674093875000},"page":"161","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pharmaco-Toxicological Effects of Atypical Synthetic Cathinone Mephtetramine (MTTA) in Mice: Possible Reasons for Its Brief Appearance over NPSs Scene"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2973-2446","authenticated-orcid":false,"given":"Giorgia","family":"Corli","sequence":"first","affiliation":[{"name":"Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-9184","authenticated-orcid":false,"given":"Micaela","family":"Tirri","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Arf\u00e8","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences and Prevention, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Borsari","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Odoardi","sequence":"additional","affiliation":[{"name":"Forensic Toxicology Laboratory, Department of Health Surveillance and Bioethics, Universit\u00e0 Cattolica del Sacro Cuore F. Policlinico Gemelli IRCCS, 00169 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Mestria","sequence":"additional","affiliation":[{"name":"Forensic Toxicology Laboratory, Department of Health Surveillance and Bioethics, Universit\u00e0 Cattolica del Sacro Cuore F. Policlinico Gemelli IRCCS, 00169 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7530-2968","authenticated-orcid":false,"given":"Sabina","family":"Strano-Rossi","sequence":"additional","affiliation":[{"name":"Forensic Toxicology Laboratory, Department of Health Surveillance and Bioethics, Universit\u00e0 Cattolica del Sacro Cuore F. Policlinico Gemelli IRCCS, 00169 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-1669","authenticated-orcid":false,"given":"Margherita","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-4007","authenticated-orcid":false,"given":"Rosa Maria","family":"Gaudio","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"},{"name":"University Center for Studies on Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrine","family":"Bilel","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-2882","authenticated-orcid":false,"given":"Matteo","family":"Marti","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, Section of Legal Medicine, LTTA Center and University Center of Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"},{"name":"University Center for Studies on Gender Medicine, University of Ferrara, 44121 Ferrara, Italy"},{"name":"Collaborative Center for the Italian National Early Warning System, Department of Anti-Drug Policies, Presidency of the Council of Ministers, 00186 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/add.12287","article-title":"Getting up to speed with the public health and regulatory challenges posed by new psychoactive substances in the information age","volume":"108","author":"Griffiths","year":"2013","journal-title":"Addiction"},{"key":"ref_2","unstructured":"(2022, December 05). United Nations Office on Drugs and Crime, Current NPS Threats, UNODC Laboratory and Scientific Service Portals. Available online: https:\/\/www.unodc.org\/unodc\/en\/scientists\/current-nps-threats.html."},{"key":"ref_3","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) (2021). European Drug Report 2020: Trends and Developments, Publications Office of the European Union."},{"key":"ref_4","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (2021). Impact of COVID-19 on Drug Markets, Use, Harms and Drug Services in the Community and Prisons: Results from an EMCDDA Trendspotter Study, Publications Office of the European Union."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fnins.2016.00153","article-title":"Neuropharmacology of New Psychoactive Substances (NPS): Focus on the Rewarding and Reinforcing Properties of Cannabimimetics and Amphetamine-Like Stimulants","volume":"10","author":"Miliano","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.pharmthera.2017.10.022","article-title":"Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data?","volume":"182","author":"Hondebrink","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s12640-020-00229-6","article-title":"Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment","volume":"39","author":"Vaz","year":"2021","journal-title":"Neurotox. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5042\/daat.2010.0123","article-title":"Tweaking, bombing, dabbing and stockpiling: The emergence of mephedrone and the perversity of prohibition","volume":"10","author":"Measham","year":"2021","journal-title":"Drugs Alcohol Today"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.drugalcdep.2011.02.011","article-title":"A web-based survey on mephedrone","volume":"118","author":"King","year":"2011","journal-title":"Drug Alcohol Depend."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-3-319-78707-7_9","article-title":"Synthetic cathinones\u2014Prevalence and motivations for use","volume":"Volume 12","author":"Zawilska","year":"2018","journal-title":"Synthetic Cathinones: Novel Addiction and Stimulatory Psychoactive Substances"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1007\/s00204-021-03083-3","article-title":"An updated review on synthetic cathinones","volume":"95","author":"Soares","year":"2021","journal-title":"Arch. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/npp.2012.204","article-title":"Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive \u2018bath salts\u2019 products","volume":"38","author":"Baumann","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_13","unstructured":"(2022, December 05). United Nations Office on Drugs and Crime, Early Warning Advisory on NPS, UNODC Laboratory and Scientific Service Portals. Available online: https:\/\/www.unodc.org\/LSS\/Page\/NPS\/Resources."},{"key":"ref_14","unstructured":"United Nations Office on Drugs and Crime (2022, December 05). The Challenge of Synthetic Drugs in East and South-East Asia and Oceania. Trends and Patterns of Amphetamine-Type Stimulants and New Psychoactive Substances, UNODC Laboratory and Scientific Service Portals. Available online: https:\/\/www.unodc.org\/documents\/scientific\/Trends_and_Patterns_of_ATS_and_NPS_2017.pdf."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.17711\/SM.0185-3325.2017.010","article-title":"An approach to the new psychoactive drugs phenomenon","volume":"40","year":"2017","journal-title":"Salud Ment."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1476-5381.2012.02145.x","article-title":"Pharmacological characterization of designer cathinones in vitro","volume":"168","author":"Simmler","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuropharm.2013.11.008","article-title":"Monoamine transporter and receptor interaction profiles of a new series of designer cathinones","volume":"79","author":"Simmler","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_18","first-page":"w14043","article-title":"Novel psychoactive substances (designer drugs): Overview and pharmacology of modulators of monoamine signaling","volume":"145","author":"Liechti","year":"2015","journal-title":"Swiss Med. Wkly."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1002\/dta.3044","article-title":"Metabolism study and toxicological determination of mephtetramine in biological samples by liquid chromatography coupled with high-resolution mass spectrometry","volume":"13","author":"Odoardi","year":"2021","journal-title":"Drug Test. Anal."},{"key":"ref_20","unstructured":"European Monitoring Centre for Drugs and Drug Abuse (EMCDDA)\u2014Europol (2013). Annual Report on the Implementation of Council Decision; 2005\/387\/JHA, Publications Office of the European Union."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/rcm.6969","article-title":"An analytical approach to the forensic identification of different classes of new psychoactive substances (NPSs) in seized materials","volume":"28","author":"Odoardi","year":"2014","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.forsciint.2016.01.037","article-title":"A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013\u20132015","volume":"265","author":"Odoardi","year":"2016","journal-title":"Forensic Sci. Int."},{"key":"ref_23","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)\u2013Europol (2017). European Drug Report 2017: Trends and Developments, European Monitoring Centre for Drugs and Drug Addiction."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8314","DOI":"10.1038\/s41598-019-44830-y","article-title":"Characterization of a recently detected halogenated aminorex derivative: Para-fluoro-4-methylaminorex (4\u2032F-4-MAR)","volume":"9","author":"Ventura","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_25","unstructured":"(2022, December 18). Bluelight. Available online: https:\/\/bluelight.org\/xf\/threads\/mtta-and-meop-waste-or-useful-if-combinated-with-something.777781\/#post-13369987."},{"key":"ref_26","unstructured":"(2022, December 18). Bluelight. Available online: https:\/\/bluelight.org\/xf\/threads\/new-and-less-new-rcs-alphabet-soup.715035\/page-53#post-13296946."},{"key":"ref_27","unstructured":"(2022, December 18). Land der Tr\u00e4ume. Available online: https:\/\/www.land-der-traeume.de\/forum.php?t=35537."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.aap.2013.09.009","article-title":"Prevalence of synthetic cannabinoids in blood samples from Norwegian drivers suspected of impaired driving during a seven weeks period","volume":"62","author":"Tuv","year":"2014","journal-title":"Accid. Anal. Prev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/1556-4029.13433","article-title":"Drug recognition evaluation and chemical confirmation of a 25C-NBOMe-impaired driver","volume":"62","author":"Rajotte","year":"2017","journal-title":"J. Forensic Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2174\/1570159X15666170828162057","article-title":"Correlation between blood and oral fluid psychoactive drug concentrations and cognitive impairment in driving under the influence of drugs","volume":"16","author":"Busardo","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"109854","DOI":"10.1016\/j.forsciint.2019.06.012","article-title":"A review of drug abuse in recently reported cases of driving under the influence of drugs (DUID) in Asia, USA, and Europe","volume":"302","author":"Han","year":"2019","journal-title":"Forensic Sci. Int."},{"key":"ref_32","unstructured":"Bilel, S., Giorgetti, A., Tirri, M., Arf\u00e8, R., Cristofori, V., Marchetti, B., Corli, G., Caruso, L., Zauli, G., and Giorgetti, R. (2022). Sensorimotor Alterations Induced by Novel Fentanyl Analogs in Mice: Possible Impact on Human Driving Performances. Curr. Neuropharmacol., Epub ahead of printing."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"875722","DOI":"10.3389\/fpsyt.2022.875722","article-title":"Effect of -NBOMe Compounds on Sensorimotor, Motor, and Prepulse Inhibition Responses in Mice in Comparison With the 2C Analogs and Lysergic Acid Diethylamide: From Preclinical Evidence to Forensic Implication in Driving Under the Influence of Drugs","volume":"13","author":"Tirri","year":"2022","journal-title":"Front. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Nihal","year":"2008","journal-title":"FASEB J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuropharm.2015.02.008","article-title":"Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice","volume":"95","author":"Vigolo","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2015.05.021","article-title":"JWH-018 impairs sensorimotor functions in mice","volume":"300","author":"Ossato","year":"2015","journal-title":"Neuroscience"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuropharm.2018.08.017","article-title":"Neurological, sensorimotor and cardiorespiratory alterations induced by methoxetamine, ketamine and phencyclidine in mice","volume":"141","author":"Ossato","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"108110","DOI":"10.1016\/j.neuropharm.2020.108110","article-title":"In vitro and in vivo pharmacological characterization of the synthetic opioid MT-45","volume":"171","author":"Bilel","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s00213-021-05852-5","article-title":"Comparison of N-methyl-2-pyrrolidone (NMP) and the \"date rape\" drug GHB: Behavioral toxicology in the mouse model","volume":"238","author":"Bilel","year":"2021","journal-title":"Psychopharmacology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"109020","DOI":"10.1016\/j.neuropharm.2022.109020","article-title":"In vitro and in vivo pharmaco-dynamic study of the novel fentanyl derivatives: Acrylfentanyl, Ocfentanyl and Furanylfentanyl","volume":"209","author":"Bilel","year":"2022","journal-title":"Neuropharmacology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100039","DOI":"10.1016\/j.etdah.2022.100039","article-title":"Behavioral and binding studies on the quinolinyl ester indoles 5F-PB22 (5F-QUPIC) and BB-22 (QUCHIC) in the mouse model","volume":"2","author":"Corli","year":"2022","journal-title":"Emerg. Trends Drugs Addict. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s11419-018-0444-7","article-title":"MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: Tips in the debate on potential MDMA unsafety in human activity","volume":"37","author":"Marti","year":"2019","journal-title":"Forensic Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11419-020-00544-9","article-title":"Metabolic profile of the synthetic drug 4,4\u2032-dimethylaminorex in urine by LC\u2013MS-based techniques: Selection of the most suitable markers of its intake","volume":"39","author":"Chieffi","year":"2021","journal-title":"Forensic Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/dta.2900","article-title":"Urinary excretion profile of methiopropamine in mice following intraperitoneal administration: A liquid chromatography-tandem mass spectrometry investigation","volume":"13","author":"Camuto","year":"2021","journal-title":"Drug Test. Anal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/jat\/bkaa111","article-title":"Metabolism Study of N-Methyl 2-Aminoindane (NM2AI) and Determination of Metabolites in Biological Samples by LC-HRMS","volume":"45","author":"Mestria","year":"2021","journal-title":"J. Anal. Toxicol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.rvsc.2016.03.012","article-title":"Agreement of manual cell counts and automated counts of the scil Vet abc Plus(+) hematology analyzer for analysis of equine synovial fluid","volume":"106","author":"Oosterlinck","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jemermed.2013.11.104","article-title":"Synthetic cathinones (\"bath salts\")","volume":"46","author":"Banks","year":"2014","journal-title":"J. Emerg. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00204-013-1163-9","article-title":"Khat and synthetic cathinones: A review","volume":"88","author":"Valente","year":"2014","journal-title":"Arch. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/164_2018_178","article-title":"Neuropharmacology of Synthetic Cathinones","volume":"252","author":"Baumann","year":"2018","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00204-020-02693-7","article-title":"Designer drugs: Mechanism of action and adverse effects","volume":"94","author":"Luethi","year":"2020","journal-title":"Arch. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/npp.2011.304","article-title":"The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue","volume":"37","author":"Baumann","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00414-020-02302-3","article-title":"Methiopropamine and its acute behavioral effects in mice: Is there a gray zone in new psychoactive substances users?","volume":"134","author":"Bilel","year":"2020","journal-title":"Int. J. Leg. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Tirri, M., Frisoni, P., Bilel, S., Arf\u00e8, R., Trapella, C., Fantinati, A., Corli, G., Marchetti, B., De-Giorgio, F., and Camuto, C. (2021). Worsening of the Toxic Effects of (\u00b1)Cis-4,4\u2032-DMAR Following Its Co-Administration with (\u00b1)Trans-4,4\u2032-DMAR: Neuro-Behavioural, Physiological, Immunohistochemical and Metabolic Studies in Mice. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168771"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1038\/s41598-017-04273-9","article-title":"Differential regulations of vestibulo-ocular reflex and optokinetic response by \u03b2- and \u03b12-adrenergic receptors in the cerebellar flocculus","volume":"7","author":"Wakita","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.tins.2011.12.001","article-title":"The vestibular system: Multimodal integration and encoding of self-motion for motor control","volume":"35","author":"Cullen","year":"2012","journal-title":"Trends Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/jeb.199.1.201","article-title":"Path integration in mammals and its interaction with visual landmarks","volume":"199","author":"Etienne","year":"1996","journal-title":"J. Exp. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.heares.2016.10.017","article-title":"Serotonin modulates response properties of neurons in the dorsal cochlear nucleus of the mouse","volume":"344","author":"Felix","year":"2017","journal-title":"Hear. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1111\/j.1360-0443.2011.03502.x","article-title":"Mephedrone: Use, subjective effects and health risks","volume":"106","author":"Winstock","year":"2011","journal-title":"Addiction"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1528-1167.2006.00934.x","article-title":"Neocortical and thalamic spread of amygdala kindled seizures","volume":"48","author":"Blumenfeld","year":"2007","journal-title":"Epilepsia"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10281","DOI":"10.1523\/JNEUROSCI.0888-15.2015","article-title":"Breathing Inhibited When Seizures Spread to the Amygdala and upon Amygdala Stimulation","volume":"35","author":"Dlouhy","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e134852","DOI":"10.1172\/jci.insight.134852","article-title":"A human amygdala site that inhibits respiration and elicits apnea in pediatric epilepsy","volume":"5","author":"Rhone","year":"2020","journal-title":"JCI Insight"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev.neuro.26.041002.131103","article-title":"Breathing: Rhythmicity, plasticity, chemosensitivity","volume":"26","author":"Feldman","year":"2003","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fnana.2020.00058","article-title":"Monosynaptic Projections to Excitatory and Inhibitory preB\u00f6tzinger Complex Neurons","volume":"14","author":"Yang","year":"2020","journal-title":"Front. Neuroanat."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1749-6632.1998.tb08319.x","article-title":"Hypothalamic neurons. Mechanisms of sensitivity to temperature","volume":"856","author":"Boulant","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"R1207","DOI":"10.1152\/ajpregu.00109.2011","article-title":"Central circuitries for body temperature regulation and fever","volume":"301","author":"Nakamura","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0006-8993(92)90972-C","article-title":"Different types of norepinephrinergic receptors are involved in preoptic area mediated independent modulation of sleep-wakefulness and body temperature","volume":"591","author":"Mallick","year":"1992","journal-title":"Brain Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1476-5381.1979.tb08707.x","article-title":"Evidence for an endogenous dopamine-mediated hypothermia in the rat","volume":"67","author":"Cox","year":"1979","journal-title":"Br. J. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.drugalcdep.2012.07.003","article-title":"Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone)","volume":"127","author":"Miller","year":"2013","journal-title":"Drug Alcohol Depend."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00213-007-1060-0","article-title":"The effects of methamphetamine on core body temperature in the rat--part 2: An escalating regimen","volume":"198","author":"Myles","year":"2008","journal-title":"Psychopharmacology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1007\/s00213-015-3944-8","article-title":"In vivo potency and efficacy of the novel cathinone \u03b1-pyrrolidinopentiophenone and 3,4-methylenedioxypyrovalerone: Self-administration and locomotor stimulation in male rats","volume":"232","author":"Aarde","year":"2015","journal-title":"Psychopharmacology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1476-5381.2012.01998.x","article-title":"Comparative neuropharmacology of three psychostimulant cathinone derivatives: Butylone, mephedrone and methylone","volume":"167","author":"Pubill","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/adb.12472","article-title":"The new designer drug buphedrone produces rewarding properties via dopamine D1 receptor activation","volume":"23","author":"Oh","year":"2018","journal-title":"Addict. Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s12640-018-9973-4","article-title":"Methcathinone and 3-Fluoromethcathinone Stimulate Spontaneous Horizontal Locomotor Activity in Mice and Elevate Extracellular Dopamine and Serotonin Levels in the Mouse Striatum","volume":"35","author":"Wojcieszak","year":"2019","journal-title":"Neurotox. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s12640-020-00227-8","article-title":"Four Synthetic Cathinones: 3-Chloromethcathinone, 4-Chloromethcathinone, 4-Fluoro-\u03b1-Pyrrolidinopentiophenone, and 4-Methoxy-\u03b1-Pyrrolidinopentiophenone Produce Changes in the Spontaneous Locomotor Activity and Motor Performance in Mice with Varied Profiles","volume":"38","author":"Wojcieszak","year":"2020","journal-title":"Neurotox. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00429052","article-title":"A functional effect of dopamine in the nucleus accumbens and in some other dopamine-rich parts of the rat brain","volume":"45","author":"Jackson","year":"1975","journal-title":"Psychopharmacologia"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0091-3057(85)90025-5","article-title":"A rapid and simple behavioural screening method for simultaneous assessment of limbic and striatal blocking effects of neuroleptic drugs","volume":"23","author":"Ljungberg","year":"1985","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1124\/jpet.108.146142","article-title":"Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil","volume":"329","author":"Zolkowska","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1124\/jpet.110.176271","article-title":"In vivo effects of amphetamine analogs reveal evidence for serotonergic inhibition of mesolimbic dopamine transmission in the rat","volume":"337","author":"Baumann","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuropharm.2017.07.026","article-title":"Pharmacological profile of mephedrone analogs and related new psychoactive substances","volume":"134","author":"Luethi","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1080\/09537104.2018.1528345","article-title":"Blood collection, platelet isolation and measurement of platelet count and size in mice-a practical guide","volume":"30","author":"Aurbach","year":"2019","journal-title":"Platelets"},{"key":"ref_81","unstructured":"Weiss, D.J., and Wardrop, K.J. (2010). Schalm\u2019s Veterinary Hematology, Wiley Blackwell. [6th ed.]."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12011-007-8047-x","article-title":"Effects of restraint stress on iron, zinc, calcium, and magnesium whole blood levels in mice","volume":"121","author":"Teng","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.clinbiochem.2005.12.006","article-title":"Heparin interference in whole blood sodium measurements in a pediatric setting","volume":"39","author":"Yip","year":"2006","journal-title":"Clin. Biochem."},{"key":"ref_84","first-page":"76","article-title":"Effect of stress on calcium homeostasis in muscular tissues","volume":"49","author":"Liashenko","year":"2003","journal-title":"Fiziolohichnyi Zhurnal"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1046\/j.1460-9568.2003.02845.x","article-title":"Acute stress increases calcium current amplitude in rat hippocampus: Temporal changes in physiology and gene expression","volume":"18","author":"Velzing","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/clc.4960270411","article-title":"Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans","volume":"27","author":"Takase","year":"2004","journal-title":"Clin. Cardiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.fct.2013.12.041","article-title":"Toxicological assessment of combined lead and cadmium: Acute and sub-chronic toxicity study in rats","volume":"65","author":"Yuan","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_88","unstructured":"Lala, V., Zubair, M., and Minter, D.A. (2022). Liver Function Tests. StatPearls, StatPearls Publishing."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.2147\/DMSO.S188856","article-title":"Hypertriglyceridemia-Related Pancreatitis in Patients With Type 2 Diabetes: Links And Risks","volume":"12","author":"Shemesh","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1089\/met.2020.0092","article-title":"Triglyceride-Glucose Index and Related Parameters Predicted Metabolic Syndrome in Nigerians","volume":"19","author":"Raimi","year":"2021","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1475-2840-10-34","article-title":"Low serum amylase in association with metabolic syndrome and diabetes: A community-based study","volume":"10","author":"Nakajima","year":"2011","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_92","unstructured":"Clarke, W., and Mark, A.M. (2020). Urinalysis. Contemporary Practice in Clinical Chemistry, Academic Press. [4th ed.]."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jpba.2018.09.034","article-title":"Development of new methods for determination of bilirubin","volume":"162","author":"Ngashangva","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1523-1755.2003.00840.x","article-title":"Pathophysiology of proteinuria","volume":"63","author":"Bazzi","year":"2003","journal-title":"Kidney Int."},{"key":"ref_95","first-page":"77","article-title":"Urine testing for diabetic analysis","volume":"28","author":"Marsden","year":"2015","journal-title":"Community Eye Health"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Greaves, P. (2011). Hemopoietic and Lymphatic Systems. Histopathology of Preclinical Toxicity Studies, Academic Press. [4th ed.].","DOI":"10.1016\/B978-0-444-53856-7.00004-X"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/7854_2016_53","article-title":"Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs","volume":"32","author":"Baumann","year":"2017","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00213-018-5059-5","article-title":"Structure-activity relationships of bath salt components: Substituted cathinones and benzofurans at biogenic amine transporters","volume":"236","author":"Eshleman","year":"2019","journal-title":"Psychopharmacology"},{"key":"ref_99","unstructured":"(2022, December 18). Bluelight. Available online: https:\/\/bluelight.org\/xf\/threads\/mephtetramine-methoxypiperamide.668456\/."},{"key":"ref_100","unstructured":"(2022, December 18). Land der Tr\u00e4ume. Available online: https:\/\/www.land-der-traeume.de\/forum.php?t=35538."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/2\/161\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:09:26Z","timestamp":1760119766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/2\/161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,18]]},"references-count":100,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["brainsci13020161"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13020161","relation":{},"ISSN":["2076-3425"],"issn-type":[{"value":"2076-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,18]]}}}