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Adair Charitable Foundation and Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brazil (CAPES)","award":["MOP-11-51-31","RFN 152985","159815","162303","MOP-11-51-31-team 1","NIRG-12-92090","NIRP-12-259245","001","88881.128434\/2016-01"],"award-info":[{"award-number":["MOP-11-51-31","RFN 152985","159815","162303","MOP-11-51-31-team 1","NIRG-12-92090","NIRP-12-259245","001","88881.128434\/2016-01"]}]},{"DOI":"10.13039\/501100002322","name":"CAPES Foundation\u2014Brazil","doi-asserted-by":"publisher","award":["MOP-11-51-31","RFN 152985","159815","162303","MOP-11-51-31-team 1","NIRG-12-92090","NIRP-12-259245","001","88881.128434\/2016-01"],"award-info":[{"award-number":["MOP-11-51-31","RFN 152985","159815","162303","MOP-11-51-31-team 1","NIRG-12-92090","NIRP-12-259245","001","88881.128434\/2016-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer\u2019s disease (AD). In this study, we assessed patients\u2019 scores in two delayed episodic memory tests, and investigated their associations with regional amyloid deposition and brain metabolism across the clinical spectrum of AD. We assessed the clinical, neuropsychological, structural, and positron emission tomography (PET) baseline measures of participants from the Alzheimer\u2019s Disease Neuroimaging Initiative. Subjects were classified as cognitively normal (CN), or with early (EMCI) or late (LMCI) mild cognitive impairment, or AD dementia. The memory outcome measures of interest were logical memory 30 min delayed recall (LM30) and Rey Auditory Verbal Learning Test 30 min delayed recall (RAVLT30). Voxel-based [18F]florbetapir and [18F]FDG uptake-ratio maps were constructed and correlations between PET images and cognitive scores were calculated. We found that EMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake on the right parieto-occipital region. LMCI individuals had LM30 scores positively associated with left lateral temporal lobe [18F]FDG uptake, and RAVLT30 scores positively associated with [18F]FDG uptake in the left parietal lobe and in the right enthorhinal cortex. Additionally, LMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake in the right frontal lobe. For the AD group, [18F]FDG uptake was positively correlated with LM30 in the left temporal lobe and with RAVLT30 in the right frontal lobe, and [18F]florbetapir uptake was negatively correlated with LM30 scores in the right parietal and left frontal lobes. The results show that the association between regional brain metabolism and the severity of episodic memory deficits is dependent on the clinical disease stage, suggesting a dynamic relationship between verbal episodic memory deficits, AD pathophysiology, and clinical disease stages.<\/jats:p>","DOI":"10.3390\/brainsci13020232","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T03:56:27Z","timestamp":1675050987000},"page":"232","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dynamic Amyloid and Metabolic Signatures of Delayed Recall Performance within the Clinical Spectrum of Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Marina","family":"Tedeschi Dauar","sequence":"first","affiliation":[{"name":"Douglas Mental Health University Institute, 6875 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada"},{"name":"Centre for the Studies in the Prevention of Alzheimer\u2019s Disease, 6875 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada"},{"name":"CAPES Foundation, Ministry of Education of Brazil, Brasilia 70040-020, DF, Brazil"},{"name":"McGill University, Montreal, QC H3A 0G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tharick Ali","family":"Pascoal","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC H3A 0G4, Canada"},{"name":"Translational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada"},{"name":"Departments of Psychiatry and Neurology, University of Pittsburgh School of Medicine, 3811 O\u2019Hara St, Pittsburgh, PA 15213, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Therriault","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC H3A 0G4, Canada"},{"name":"Translational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada"},{"name":"Montreal Neurological Institute, 3801 University st., Montreal, QC H3A 2B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jared","family":"Rowley","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mohaddes","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Shin","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo R.","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Translational Neuroimaging Laboratory, 6825 Lasalle Boulevard, Montreal, QC H4H 1R3, Canada"},{"name":"Department of Biochemistry, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4242-9158","authenticated-orcid":false,"given":"Simon Fristed","family":"Eskildsen","sequence":"additional","affiliation":[{"name":"Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Universitetsbyen 3, 8000 Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir S.","family":"Fonov","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University St., Montreal, QC H3A 2B4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Gauthier","sequence":"additional","affiliation":[{"name":"McGill University, Montreal, QC H3A 0G4, Canada"},{"name":"Translational Neuroimaging 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Alzheimer\u2019s Disease Facts and Figures, Alzheimer\u2019s Association."},{"key":"ref_2","unstructured":"(2022). World Health Organization\u2014Dementia Fact Sheet, World Health Organization."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0165-6147(91)90609-V","article-title":"Amyloid Deposition as the Central Event in the Aetiology of Alzheimer\u2019s Disease","volume":"12","author":"Hardy","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer\u2019s Disease: The Amyloid Cascade Hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/archneurol.2011.70","article-title":"Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease","volume":"68","author":"Hyman","year":"2011","journal-title":"Arch. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking Pathophysiological Processes in Alzheimer\u2019s Disease: An Updated Hypothetical Model of Dynamic Biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0028-3932(95)00151-4","article-title":"Analysis of the Episodic Memory Deficit in Early Alzheimer\u2019s Disease: Evidence from the Doors and People Test","volume":"34","author":"Greene","year":"1996","journal-title":"Neuropsychologia"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00002093-199809000-00006","article-title":"Sensitivity and Specificity of Some Neuropsychological Markers of Alzheimer Dementia","volume":"12","author":"Gainotti","year":"1998","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","article-title":"Research Criteria for the Diagnosis of Alzheimer\u2019s Disease: Revising the NINCDS-ADRDA Criteria","volume":"6","author":"Dubois","year":"2007","journal-title":"Lancet Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.cortex.2010.12.002","article-title":"Working Memory, Attention, and Executive Function in Alzheimer\u2019s Disease and Frontotemporal Dementia","volume":"48","author":"Stopford","year":"2012","journal-title":"Cortex"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/jnnp-2014-308094","article-title":"A\u03b2 Imaging with 18F-Florbetaben in Prodromal Alzheimer\u2019s Disease: A Prospective Outcome Study","volume":"86","author":"Ong","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1212\/WNL.0b013e318245f447","article-title":"Biomarker Validation of a Cued Recall Memory Deficit in Prodromal Alzheimer Disease","volume":"78","author":"Wagner","year":"2012","journal-title":"Neurology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3233\/JAD-121684","article-title":"Metabolic Correlates of Rey Auditory Verbal Learning Test in Elderly Subjects with Memory Complaints","volume":"39","author":"Brugnolo","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_14","unstructured":"Ray, A. (1964). L\u2019examen Clinique En Psychologie, Presse Universitaires de France."},{"key":"ref_15","first-page":"21","article-title":"L\u2019examen Psychologique Dans Les Cas d\u2019encephopathie Traumatique","volume":"28","author":"Ray","year":"1941","journal-title":"Arch. De Psychol."},{"key":"ref_16","unstructured":"Schmidt, M. (1996). Rey Auditory Verbal Learning Test: A Handbook, Western Psychological Services."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/00223980.1945.9917223","article-title":"A Standardized Memory Scale for Clinical Use","volume":"19","author":"Wechsler","year":"1945","journal-title":"J. Psychol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/01688638708405063","article-title":"Logical Memory Subtest of the Wechsler Memory Scale: Age and Education Norms and Alternate-Form Reliability of Two Scoring Systems","volume":"9","author":"Abikoff","year":"1987","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1093\/brain\/awf097","article-title":"The Neural Substrates of Episodic Memory Impairment in Alzheimer\u2019s Disease as Revealed by FDG-PET: Relationship to Degree of Deterioration","volume":"125","author":"Desgranges","year":"2002","journal-title":"Brain"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/brain\/awn320","article-title":"Episodic Memory Loss Is Related to Hippocampal-Mediated Beta-Amyloid Deposition in Elderly Subjects","volume":"132","author":"Mormino","year":"2009","journal-title":"Brain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/brain\/116.4.903","article-title":"Evidence of Multiple Memory Systems in the Human Brain. A [18F]FDG PET Metabolic Study","volume":"116","author":"Perani","year":"1993","journal-title":"Brain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF00588331","article-title":"Cognitive Impairment in Alzheimer\u2019s Disease Correlates with Ventricular Width and Atrophy-Corrected Cortical Glucose Metabolism","volume":"37","author":"Slansky","year":"1995","journal-title":"Neuroradiology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/brain\/121.4.611","article-title":"The Neural Substrates of Memory Systems Impairment in Alzheimer\u2019s Disease. A PET Study of Resting Brain Glucose Utilization","volume":"121","author":"Desgranges","year":"1998","journal-title":"Brain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1097\/00001756-200103260-00013","article-title":"Entorhinal Cortex Disruption Causes Memory Deficit in Early Alzheimer\u2019s Disease as Shown by PET","volume":"12","author":"Eustache","year":"2001","journal-title":"Neuroreport"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neurobiolaging.2005.03.015","article-title":"Resting State Glucose Utilization and the CERAD Cognitive Battery in Patients with Alzheimer\u2019s Disease","volume":"27","author":"Teipel","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1212\/01.wnl.0000244749.20056.d4","article-title":"Amyloid, Hypometabolism, and Cognition in Alzheimer Disease: An [11C]PIB and [18F]FDG PET Study","volume":"68","author":"Edison","year":"2007","journal-title":"Neurology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s00259-012-2230-9","article-title":"Quantitative Longitudinal Interrelationships between Brain Metabolism and Amyloid Deposition during a 2-Year Follow-up in Patients with Early Alzheimer\u2019s Disease","volume":"39","author":"Yousefi","year":"2012","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1093\/brain\/awg196","article-title":"Dissociating Atrophy and Hypometabolism Impact on Episodic Memory in Mild Cognitive Impairment","volume":"126","author":"Chetelat","year":"2003","journal-title":"Brain"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wu, L., Rowley, J., Mohades, S., Leuzy, A., Dauar, M.T., Shin, M., Fonov, V., Jia, J., Gauthier, S., and Rosa-Neto, P. (2012). Dissociation between Brain Amyloid Deposition and Metabolism in Early Mild Cognitive Impairment. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047905"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00004728-199403000-00005","article-title":"Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space","volume":"18","author":"Collins","year":"1994","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1212\/WNL.44.5.867","article-title":"Memory Function in Very Early Alzheimer\u2019s Disease","volume":"44","author":"Petersen","year":"1994","journal-title":"Neurology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00429-014-0744-6","article-title":"Specific and Disease Stage-Dependent Episodic Memory-Related Brain Activation Patterns in Alzheimer\u2019s Disease: A Coordinate-Based Meta-Analysis","volume":"220","author":"Nellessen","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1447-0594.2012.00865.x","article-title":"Characteristics of Cognitive Function in Early and Late Stages of Amnestic Mild Cognitive Impairment","volume":"13","author":"Doi","year":"2013","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jalz.2012.09.017","article-title":"AD Dementia Risk in Late MCI, in Early MCI, and in Subjective Memory Impairment","volume":"10","author":"Jessen","year":"2014","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jalz.2010.03.006","article-title":"Clinical Core of the Alzheimer\u2019s Disease Neuroimaging Initiative: Progress and Plans","volume":"6","author":"Aisen","year":"2010","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1212\/WNL.38.3.359","article-title":"The NINCDS-ADRDA Work Group Criteria for the Clinical Diagnosis of Probable Alzheimer\u2019s Disease: A Clinicopathologic Study of 57 Cases","volume":"38","author":"Tierney","year":"1988","journal-title":"Neurology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/3-540-48714-X_16","article-title":"ANIMAL+INSECT: Improved Cortical Structure Segmentation","volume":"Volume 1613","author":"Kuba","year":"1999","journal-title":"Information Processing in Medical Imaging"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jagp.2012.11.016","article-title":"Cognition and Amyloid Load in Alzheimer Disease Imaged with Florbetapir F 18(AV-45) Positron Emission Tomography","volume":"21","author":"Rosenberg","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.neurobiolaging.2008.01.016","article-title":"Clinical Severity of Alzheimer\u2019s Disease Is Associated with PIB Uptake in PET","volume":"30","author":"Grimmer","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1016\/j.neuroimage.2004.07.026","article-title":"Unified Univariate and Multivariate Random Field Theory","volume":"23","author":"Worsley","year":"2004","journal-title":"Neuroimage"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.nicl.2013.05.008","article-title":"Neural Correlates of the DemTect in Alzheimer\u2019s Disease and Frontotemporal Lobar Degeneration\u2014A Combined MRI & FDG-PET Study","volume":"2","author":"Woost","year":"2013","journal-title":"Neuroimage Clin."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/0028-3932(85)90080-6","article-title":"Memory Disorders Associated with Huntington\u2019s Disease: Verbal Recall, Verbal Recognition and Procedural Memory","volume":"23","author":"Butters","year":"1985","journal-title":"Neuropsychologia"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/1097-4679(198903)45:2<277::AID-JCLP2270450216>3.0.CO;2-M","article-title":"Rey-Auditory Verbal Learning and Rey-Osterrieth Complex Figure Design Performance in Alzheimer\u2019s Disease and Closed Head Injury","volume":"45","author":"Bigler","year":"1989","journal-title":"J. Clin. Psychol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1528-1157.1996.tb00556.x","article-title":"Validation of the Wechsler Memory Scale-Revised in a Sample of People with Intractable Temporal Lobe Epilepsy","volume":"37","author":"Moore","year":"1996","journal-title":"Epilepsia"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.acn.2006.06.010","article-title":"Test Performance and Classification Statistics for the Rey Auditory Verbal Learning Test in Selected Clinical Samples","volume":"21","author":"Schoenberg","year":"2006","journal-title":"Arch. Clin. Neuropsychol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00429-013-0665-9","article-title":"Deficits in Memory and Visuospatial Learning Correlate with Regional Hippocampal Atrophy in MS","volume":"220","author":"Longoni","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/13803390490496678","article-title":"Age-Associated Memory Impairment of Logical Memory and Visual Reproduction","volume":"26","author":"Price","year":"2004","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/368633a0","article-title":"Brain Regions Associated with Acquisition and Retrieval of Verbal Episodic Memory","volume":"368","author":"Shallice","year":"1994","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1093\/brain\/awl178","article-title":"Two-Year Follow-up of Amyloid Deposition in Patients with Alzheimer\u2019s Disease","volume":"129","author":"Engler","year":"2006","journal-title":"Brain"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1552-6569.2008.00328.x","article-title":"Correlation between Cognitive Deficits and Glucose Hypometabolism in Mild Cognitive Impairment","volume":"20","author":"Nishi","year":"2010","journal-title":"J. Neuroimaging"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s11682-012-9208-x","article-title":"Relationship between Baseline Brain Metabolism Measured Using [18F]FDG PET and Memory and Executive Function in Prodromal and Early Alzheimer\u2019s Disease","volume":"6","author":"Habeck","year":"2012","journal-title":"Brain Imaging Behav."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Frisch, S., Dukart, J., Vogt, B., Horstmann, A., Becker, G., Villringer, A., Barthel, H., Sabri, O., M\u00fcller, K., and Schroeter, M.L. (2013). Dissociating Memory Networks in Early Alzheimer\u2019s Disease and Frontotemporal Lobar Degeneration\u2014A Combined Study of Hypometabolism and Atrophy. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055251"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/155005941104200207","article-title":"Bihemispheric Cerebral FDG PET Correlates of Cognitive Dysfunction as Assessed by the CERAD in Alzheimer\u2019s Disease","volume":"42","author":"Hunt","year":"2011","journal-title":"Clin. EEG Neurosci."}],"container-title":["Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/2\/232\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:19:44Z","timestamp":1760120384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-3425\/13\/2\/232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["brainsci13020232"],"URL":"https:\/\/doi.org\/10.3390\/brainsci13020232","relation":{},"ISSN":["2076-3425"],"issn-type":[{"type":"electronic","value":"2076-3425"}],"subject":[],"published":{"date-parts":[[2023,1,30]]}}}