{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:18:33Z","timestamp":1790619513790,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Sciences"],"abstract":"<jats:p>Objectives: To investigate the effect of tiapride and topiramate on patients with Tourette syndrome (TS). Methods: This retrospective analysis included 126 children diagnosed with TS at Children\u2019s Hospital of Chongqing Medical University from 2019 to 2021, with treatment including tiapride (n = 60) and topiramate (n = 66). Their tic severity values were assessed with the Yale Global Tic Severity Scale (YGTSS). Furthermore, behavioral and emotional problems were assessed with the Conner\u2019s Parent Rating Scale (CPRS) and the Children Behavior Checklist (CBCL). Results: Compared with premedication, the scores of tic severity were significantly decreased in both tiapride and topiramate groups after treatment, especially topiramate. Moreover, it was noted that five subscores of CPRS were significantly reduced in TS patients thanks to medication. However, there was no significant difference in CBCL after treatment, in both tiapride and topiramate groups. Conclusions: Tiapride and topiramate were proven to be effective on tics and some behavioral\/emotional problems in TS patients, and topiramate may provide better treatment.<\/jats:p>","DOI":"10.3390\/brainsci13030383","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T02:28:57Z","timestamp":1677119337000},"page":"383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of Tiapride and Topiramate on Tic Severity and Behavioral\/Emotional Problems in Children with Tourette Syndrome: A Retrospective Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-3922","authenticated-orcid":false,"given":"Xuanzi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400010, China"},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400010, China"},{"name":"Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoying","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400010, China"},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400010, China"},{"name":"Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400010, China"},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400010, China"},{"name":"Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400010, China"},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400010, China"},{"name":"Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Children\u2019s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400010, China"},{"name":"China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400010, China"},{"name":"Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Chongqing 400010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/mds.23618","article-title":"Tourette syndrome: Evolving concepts","volume":"26","author":"Jankovic","year":"2011","journal-title":"Mov. 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